Advancements in diabetic foot insoles: a comprehensive review of design, manufacturing, and performance evaluation
Frontiers in Bioengineering and Biotechnology
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1d ago
The escalating prevalence of diabetes has accentuated the significance of addressing the associated diabetic foot problem as a major public health concern. Effectively offloading plantar pressure stands out as a crucial factor in preventing diabetic foot complications. This review comprehensively examines the design, manufacturing, and evaluation strategies employed in the development of diabetic foot insoles. Furthermore, it offers innovative insights and guidance for enhancing their performance and facilitating clinical applications. Insoles designed with total contact customization, utilizi ..read more
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Editorial: Bioconversion of insect resources for sustainability
Frontiers in Bioengineering and Biotechnology
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1d ago
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Fabrication and characterization of Ti–12Mo/xAl2O3 bio-inert composite for dental prosthetic applications
Frontiers in Bioengineering and Biotechnology
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1d ago
Introduction: Titanium (Ti)-molybdenum(Mo) composites reinforced with ceramic nanoparticles have recently significant interest among researchers as a new type of bio-inert material used for dental prosthetic applications due to its biocompatibility, outstanding physical, mechanical and corrosion properties. The current work investigates the impact of alumina (Al2O3) nanoparticles on the properties of the Ti–12Mo composite, including microstructure, density, hardness, wear resistance, and electrochemical behavior.Methods: Ti–12Mo/xAl2O3 nanocomposites reinforced with different Al2O3 nanoparticl ..read more
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Hydrogel-chitosan and polylactic acid-polycaprolactone bioengineered scaffolds for reconstruction of mandibular defects: a preclinical in vivo study with assessment of translationally relevant aspects
Frontiers in Bioengineering and Biotechnology
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1d ago
Background: Reconstruction of mandibular bone defects is a surgical challenge, and microvascular reconstruction is the current gold standard. The field of tissue bioengineering has been providing an increasing number of alternative strategies for bone reconstruction.Methods: In this preclinical study, the performance of two bioengineered scaffolds, a hydrogel made of polyethylene glycol-chitosan (HyCh) and a hybrid core-shell combination of poly (L-lactic acid)/poly (ε-caprolactone) and HyCh (PLA-PCL-HyCh), seeded with different concentrations of human mesenchymal stromal cells (hMSCs), has be ..read more
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Supercooled preservation of cultured primary rat hepatocyte monolayers
Frontiers in Bioengineering and Biotechnology
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1d ago
Supercooled preservation (SCP) is a technology that involves cooling a substance below its freezing point without initiating ice crystal formation. It is a promising alternative to prolong the preservation time of cells, tissues, engineered tissue products, and organs compared to the current practices of hypothermic storage. Two-dimensional (2D) engineered tissues are extensively used in in vitro research for drug screening and development and investigation of disease progression. Despite their widespread application, there is a lack of research on the SCP of 2D-engineered tissues. In this stu ..read more
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Honeycomb-like biomimetic scaffold by functionalized antibacterial hydrogel and biodegradable porous Mg alloy for osteochondral regeneration
Frontiers in Bioengineering and Biotechnology
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4d ago
Introduction: Osteochondral repair poses a significant challenge due to its unique pathological mechanisms and complex repair processes, particularly in bacterial tissue conditions resulting from open injuries, infections, and surgical contamination. This study introduces a biomimetic honeycomb-like scaffold (Zn-AlgMA@Mg) designed for osteochondral repair. The scaffold consists of a dicalcium phosphate dihydrate (DCPD)-coated porous magnesium scaffold (DCPD Mg) embedded within a dual crosslinked sodium alginate hydrogel (Zn-AlgMA). This combination aims to synergistically exert antibacterial a ..read more
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Impact of blade direction on postoperative femoral head varus in PFNA fixed patients: a clinical review and biomechanical research
Frontiers in Bioengineering and Biotechnology
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4d ago
Intertrochanteric femur fracture is a common type of osteoporotic fracture in elderly patients, and postoperative femoral head varus following proximal femoral nail anti-rotation (PFNA) fixation is a crucial factor contributing to the deterioration of clinical outcomes. The cross-angle between the implant and bone might influence fixation stability. Although there is a wide range of adjustment in the direction of anti-rotation blades within the femoral neck, the impact of this direct variation on the risk of femoral head varus and its biomechanical mechanisms remain unexplored. In this study ..read more
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Design, fabrication, and evaluation of single- and multi-level 3D-printed non-covering cervical spinal fusion surgery templates
Frontiers in Bioengineering and Biotechnology
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4d ago
BackgroundCervical spinal fusion surgeries require accurate placement of the pedicle screws. Any misplacement/misalignment of these screws may lead to injuries to the spinal cord, arteries and other organs. Template guides have emerged as accurate and cost-effective tools for the safe and rapid insertions of pedicle screws.Questions/PurposesNovel patient-specific single- and multi-level non-covering templates for cervical pedicle screw insertions were designed, 3D-printed, and evaluated.MethodsCT scans of two patients were acquired to reconstruct their 3D spine model. Two sets of single-level ..read more
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Fertilizer management practices in potato cultivation: a baseline study for the introduction of GE potato in Bangladesh
Frontiers in Bioengineering and Biotechnology
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4d ago
Genetically engineered (GE) crops have the potential to contribute to agricultural sustainability, food security, and nutritional enrichment. However, these crops cannot be released for commercial cultivation without undergoing environmental risk assessments (ERA), thus biosafety evaluation. ERA assessments are performed comparatively with their natural non-GE counterparts. As Bangladesh is progressing with GE potato research, the present study aims to collect baseline information on non-GE potato cultivation with an emphasis on current agronomic practices focusing on fertilizer management and ..read more
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Three-dimensional dynamic homogenous modeling: The biomechanical influences of leg tissue stiffness on pressure performance of compression biomedical therapeutic textiles
Frontiers in Bioengineering and Biotechnology
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4d ago
Patient compliance and therapeutic precision of compression textiles (CTs) are frequently limited by the inaccurate pressure distributions along biological bodies in physical-based compression therapy. Therefore, the biomechanical influences of physiological tissue material characteristics of lower extremities on compression generations of CTs need to be explored systematically to improve pressure management efficacy. In this study, we developed three-dimensional (3D) homogenous finite element (FE) CT-leg systems to qualitatively compare the pressure diversities along lower limbs with differen ..read more
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