Welcome back to the next instalment of respiratory GURU, this time we delve into two RCTs investigating rescue therapy for patients with CTD ILD. The EVER ILD study looks at MMF vs MMF plus rituximab, and the RECITAL study looks at rituximab vs cyclophosphamide. 2 very useful studies and I was thrilled to be joined by two national experts in the field, Dr Anjali Crawshaw and Dr Emma Derrett-Smith. Hopefully, this will make you feel more well-prepared for ILD MDTs, and give you a real insight into how these two experts view the recent literature in the context of their day-to-day practice. Here ..read more

A vibrant discussion with our two regional leads for occupational lung disease and a specialised solicitor dealing with OLD claims into how to drill down into the details of an occupational lung disease, how to refer, how to write your clinical letters and how to direct patients towards compensation if it's right for them.  Support the show ..read more

A perfect introduction to series 2, a COPD podcast with Professor Turner and Dr LJ Smith where we jump into MART for COPD,  the new P2X3 receptor agonist Filapixant, antihyperglycaemic drugs preventing COPD exacerbations and much more. Happy listening! Studies discussed: Association of the Use of Novel Antihyperglycemic Drugs With Prevention of COPD Exacerbations Among Patients With Type 2 Diabetes  BMJ. 2022 Nov 1;379:e071380. doi: 10.1136/bmj-2022-071380. PMID: 36318979; Budesonide/Formoterol Maintenance and Reliever Therapy vs Fluticasone/Salmeterol Fixed-Dose Treatment in Pat ..read more

An interview with Dr Chris Kosmidis, Clinical Senior Lecturer at Wythenshawe Hospital and Aspergillosis centre about aspergillosis. Divided into two parts, the first part of our discussion covers ABPA for the generalist, and is a goldmine of information for diagnosing, treating and monitoring response in these patients. I now feel comfortable interpreting the serology, prescribing antifungals where appropriate and how to look out for a relapse which is a long way from where I started! References for this podcast include: Kosmidis C, Denning DW. The clinical spectrum of pulmonary aspergillosi ..read more

This month's episode dives into progressive fibrosing ILD, previously a disadvantaged set of patients who have a progressive ILD but as they weren't specifically UIP they were not entitled to antifibrotic treatment. So thank goodness for the INBUILD trial back in 2020 and it's extension and NICE technological appraisal for injecting pragmastism not only in to the types of patients now referrable for antifibrotics, but also the referral criteria. This has moved away from FVC and towards radiological classification and gas transfer which we all know are useful parameters of parenchymal health. W ..read more

This month's episode is all about COPD, and I am joined by the brilliantly intelligent Professor Alice Turner. Her knowledge of the research in this field is remarkably in-depth, yet she is generous with her experience and answers the questions you want to ask but may not feel comfortable exposing the chasms in your knowledge like I did! 40 minute podcast, strap in for a detailed, transformative and revelatory podcast with an international COPD leader. Studies discussed include: Prevalence and Impact of Pulmonary Bacterial Colonisation in Stable State Chronic Obstructive Pulmonary Disease (C ..read more

This Christmas present is a summary of the recently updated guidelines for Sarcoidosis and asthma. 20 minute summary of the guidelines to listen to whilst munching on a mince pie and a glass of something festive. You're welcome. Sarcoidosis guidelines https://erj.ersjournals.com/content/58/6/2004079.long  GINA asthma guidelines https://ginasthma.org/gina-reports ..read more

November's summary of clinical respiratory updates; 30 min podcast to listen to on the way to work or any kind of multitasking so you can keep up to date without even trying. This month's papers and guidelines are: Single-case metanalysis of fat embolism syndrome https://pubmed.ncbi.nlm.nih.gov/34743891 Clinical and pathophysiological characteristics of valproate-induced pleural effusion https://pubmed.ncbi.nlm.nih.gov/34259092 Randomised trial of the P2X 3 receptor antagonist sivopixant for refractory chronic cough https://pubmed.ncbi.nlm.nih.gov/34649978 Eliapixant (BAY 1817080), a P2X3 ..read more

October's summary of clinically relevant respiratory publications released in the past month. 10 studies, and 2 interviews, your CPD for keeping up to date in just 52 minutes. List of studies discussed below 1. Evaluation of multi-component interventions for prevention of nosocomial pneumonia in older adults: a randomized, controlled trial. Eur Geriatr Med. 2021 PMID34081314 2. Management and Treatment of Patients With Obstructive Sleep Apnea Using an Intelligent Monitoring System Based on Machine Learning Aiming to Improve Continuous Positive Airway Pressure Treatment Compliance: Randomize ..read more