181 - From Meds to Machine Learning: How AI is (and will) Revolutionizing Pharmacy Practice
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
1d ago
In this episode, we discuss artificial intelligence large language models (LLMs) and how these will impact the future of the practice of pharmacy. Key Concepts Generative AI with large language models (LLMs) have already changed how healthcare is delivered to patients. In the future, these changes will be more substantial and require pharmacists and other healthcare professionals to understand the benefits and downsides of this technology. Commercial LLMs, such as ChatGPT, are not HIPAA compliant and should not be used with protected health information. Companies currently offer software prod ..read more
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180 - The Ultimate Guide to Statins: An In-Depth Drug Class Review
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
3w ago
In this episode, we review the pharmacology, indications, adverse effects, monitoring, and unique drug characteristics of HMG CoA reductase inhibitors (“statins”). Key Concepts Statins reduce LDL cholesterol by 20-60% (depending on the dose and statin potency). They have modest favorable effects on HDL and triglycerides. Clinically, statins reduce the risk of major adverse cardiac events by about 30% depending on the statin potency. There are four main groups of patients who are indicated for a statin: LDL >= 190 mg/dL, diabetes with age 40-75 years with LDL 70-189 mg/dL, those with an ele ..read more
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179 - Annual Dose of Sweetness: 2024 Updates from the American Diabetes Association Guidelines
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
1M ago
In this recurring episode, we discuss the important updates from the 2024 American Diabetes Association Guidelines! Key Concepts Tirzepatide is now recommended as one of the weight loss pharmacotherapy options along with semaglutide in patients with diabetes. The language for its use in comparison to insulin therapy has been updated similar to GLP-1RAs. The new hypoglycemia section in chapter 6 now houses all recommendations regarding screening, education, prevention, and treatment of hypoglycemia. The recommendation for prescribing glucagon has been clarified - regardless of type of diabetes ..read more
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178 - Law & Order: Pharmacy Edition. A Concise Review of High-Yield Pharmacy Law Topics for the MPJE
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
2M ago
In this episode, we speak with Janeen Winnike, the Associate Dean for Student Affairs at Rosalind Franklin and a co-course director for the Pharmacy Law course at the university. We review some of the key points regarding federal and Illinois pharmacy law – a must-listen especially for graduates preparing for their MPJE exam after graduation! Key Concepts The FDA (via the Food, Drug, and Cosmetic Act) primarily regulates manufacturers. Most regulation for pharmacies and pharmacists is via the federal Controlled Substances Act and state-based regulations (acts and administrative codes). An IND ..read more
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177 - The Antidote Arsenal: Exploring the Emergency Toolbox for Anticoagulant Reversals
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
3M ago
In this episode, we review evidence-based guidelines for the emergency reversal of warfarin, dabigatran, and the oral Xa inhibitors (apixaban, edoxaban, and rivaroxaban). Key Concepts Reversal of anticoagulation is indicated in patients with major hemorrhage or when emergency surgery is necessary. Reversal of warfarin (Coumadin®) involves a fast-acting, short-term solution (usually prothrombin complex concentrates [PCC]) and a slower-acting, long-term solution (intravenous vitamin K). Idarucizumab (Praxbind®) is the preferred reversal strategy for dabigatran (Pradaxa®). Idarucizumab is a mono ..read more
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176 - Hormonal Harmony: A Pharmacist’s Guide to Hormonal Contraceptives (Part 2)
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
3M ago
In this two part episode, we review some of the most important clinical pearls in the pharmacotherapy and practice aspects of hormonal contraceptives with a brief focus on the very first FDA approved OTC hormonal contraceptive product (Opill). Key Concepts (Part 2) Missed dose instructions are particularly important with progestin only pills (POPs). Patients should take POPs at the same time (within 3 hours) each day - missing a dose beyond this 3 hour window is considered a missed dose and requires barrier contraception. There are a wide variety of hormonal contraception options for patients ..read more
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175 - Hormonal Harmony: A Pharmacist’s Guide to Hormonal Contraceptives (Part 1)
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
4M ago
In this two part episode, we review some of the most important clinical pearls in the pharmacotherapy and practice aspects of hormonal contraceptives with a brief focus on the very first FDA approved OTC hormonal contraceptive product (Opill). Key Concepts (Part 1) The effectiveness of contraceptives varies based on “ideal use” (e.g. in a clinical trial with optimal compliance) versus “typical use” (e.g. real-world effectiveness in patients who may sometimes be less adherent than in clinical trials). Oral, patch, and ring-based hormonal contraceptives (combination estrogen-progestin or proges ..read more
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174 - Finding Your Mount Rushmore: The Journey of an Industry Pharmacist
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
4M ago
In this episode, we interview Scott Glosner, PharmD, MPH, BCPS about his extensive experience working at Pfizer in medical outcomes and as a field medical director. Dr. Glosner will share his career journey from a clinical pharmacist transitioning into the pharmaceutical industry in the late 1990s and what current pharmacists and students should know about a job in a pharmaceutical company. Key Concepts Pharmacists are playing an increasingly important role within the pharmaceutical industry. Prior clinical experience is a significant advantage to applicants for these positions. Key character ..read more
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173 - Balancing Access and Safety: The FDA's Prescription Drug Risk Mitigation Strategy (REMS)
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
6M ago
In this episode, we will discuss the definition of REMS (Risk Evaluation and Mitigation Strategies), why they exist, the role of FDA in administering REMS, types and examples of REMS, and how they impact pharmacy practice. Key Concepts The REMS (Risk Evaluation and Mitigation Strategies) program was developed in 2007 as part of the FDA’s drug risk management strategies designed to balance risk and benefits of certain drugs. Elements of REMS vary depending on the drug, but commonly include medication guides, communication plans, and other elements to assure safe use. REMS can require patients ..read more
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172 - Battle of the Clot Busters: Alteplase vs. Tenecteplase for Acute Ischemic Stroke
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
by Sean P. Kane, PharmD; Khyati Patel, PharmD
6M ago
In this episode, we review the role and indications of thrombolytics in acute ischemic stroke. The efficacy, safety, administration considerations, and cost between alteplase and tenecteplase are compared and contrasted. Key Concepts Alteplase (Activase) is a recombinant DNA version of human TPA (tissue plasminogen activator). Tenecteplase (TNKase) is similar to human TPA except it has three amino acid changes that result in a longer half-life and higher fibrin specificity. In patients with stroke, alteplase is given as a bolus followed by a 60-minute infusion. Tenecteplase is given as an IV ..read more
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