QUANTITATIVE TEST FOR CMV BY RT-PCR Home Mouth Cancer QUANTITATIVE TEST FOR CMV BY RT-PCR VIRUS DETECTION: Cytomegalovirus INDICATIONS FOR ORDERING: Detection of CMV infection in new-borns and children up to 12 months, and in immunocompromised patients, especially post-transplant METHOD USED: Real time quantitative polymerase chain reaction kits provided by Qiagen India for detection of CMV SPECIMENS – Type, storage and transport Type: Non-diluted peripheral blood sample in an EDTA (lavender) tube. PLEASE AVOID HEPARINATED SAMPLES. Whole Blood: 3 mL Transport: Specimens mu ..read more

NRAS & KRAS MUTATION TESTING BY REAL TIME QUANTITATIVE PCR Home Mouth Cancer NRAS & KRAS MUTATION TESTING BY REAL TIME QUANTITATIVE PCR MUTATION TESTED: PCR-based assay to detect mutations in NRAS and KRAS genes INDICATIONS FOR ORDERING: Gastrointestinal and lung malignancies METHOD USED: NRAS Mutation Analysis Kit, and KRAS Mutation Analysis Kit (EntroGen) SPECIMENS – Type, storage and transport • Type: Formalin fixed paraffin embedded tissue sections (Tissue block). Please provide a hematoxylin and eosin stained slide of the corresponding block, if available • Transpor ..read more

BRAF MUTATION ANALYSIS BY REAL TIME QUALITATIVE PCR Home Mouth Cancer BRAF MUTATION ANALYSIS BY REAL TIME QUALITATIVE PCR MUTATION TESTED: PCR-based assay to detect mutations in BRAF gene INDICATIONS FOR ORDERING: Malignant melanoma, Hairy cell leukemia, colorectal and lung malignancies METHOD USED: BRAF Analysis Kit by Entrogen. We also perform genomic IHC for BRAF V600E using VE1 clone using Ventana platform SPECIMENS – Type, storage and transport Type: Non-diluted peripheral blood sample/bone marrow aspirate in an EDTA (lavender) tube. Formalin fixed ..read more

MICROSATELLITE INSTABILITY TESTING Home Mouth Cancer MICROSATELLITE INSTABILITY TESTING MICROSATELLITE INSTABILITY TESTING BY FRAGMENT LENGTH ANALYSIS MUTATION TESTED: PCR-based assay to detect microsatellite instability (MSI) in human cells comparing allelic profiles of microsatellite markers. INDICATIONS FOR ORDERING: Biomarker for immunotherapy METHOD USED: MSI Analysis Kit 1.2, Promega. Alternatively, MMR protein can be valuated using immunohistochemistry. SPECIMENS – Type, storage and transport Type: Non-diluted peripheral blood sample/bone marrow aspirate in an EDTA (lavender ..read more

LYNCH SYNDROME Home Mouth Cancer LYNCH SYNDROME NEXT GENERATION SEQUENCING BASED TESTING FOR LYNCH SYNDROME MUTATION TESTED: MLH1, MSH6, MSH2, PMS2 (primarily) INDICATIONS FOR ORDERING: Bethesda criteria were revised in 2004 to guide selection of patients for MSI testing . The guideline indicated that tumors should be tested for MSI in the following clinical situations: CRC diagnosed in a patient who is less than 50 years of age. Presence of synchronous, metachronous colorectal, or other LS-associated tumors, regardless of age. CRC with the MSI-H histology diagnosed in a patient who is l ..read more

EXTENDED SOLID TUMOR PANEL – NGS Home Mouth Cancer EXTENDED SOLID TUMOR PANEL – NGS NEXT GENERATION SEQUENCING: EXTENDED SOLID TUMOR PANEL (ONCOMINE FOCUS ASSAY) MUTATION TESTED: Various (52) genes involved in solid organ malignancies indicated in the table below INDICATIONS FOR ORDERING: Lung, colorectal, pancreaticobiliary, prostate and various solid organ malignancies METHOD USED:  Next Generation Sequencing (NGS) using Oncomine Focus Assay Kit  provided by ThermoFischer Scientific (LifeTechnologies Inc, USA) SPECIMENS – Type, storage and transport Type:. Formalin fixed ..read more

QUANTITATIVE TEST FOR HBV BY RT-PCR Home Mouth Cancer QUANTITATIVE TEST FOR HBV BY RT-PCR VIRUS DETECTED: Hepatitis B virus INDICATIONS FOR ORDERING: Detection or presence of an acute or chronic HBV infection in a patient METHOD USED: Real time quantitative polymerase chain reaction kits provided by Qiagen India for detection of HBV SPECIMENS – Type, storage and transport Type: Non-diluted peripheral blood sample in an EDTA (lavender) tube. PLEASE AVOID HEPARINATED SAMPLES. Whole Blood: 3 mL Transport: Specimens must be received within 48 hours of collection Storage: Ser ..read more

QUALITATIVE TEST FOR HIGH RISK HUMAN PAPILLOMA VIRUS BY RT-PCR Home Mouth Cancer QUALITATIVE TEST FOR HIGH RISK HUMAN PAPILLOMA VIRUS BY RT-PCR VIRUS DETECTION: Human Papilloma Virus (HPV) INDICATIONS FOR ORDERING: Screening test of cervical cancer to detect the presence of HPV and triaging patients with equivocal cytology. Further, useful in monitoring vaccine efficacy, and in post-therapy follow-up cases. Molecular detection of high risk HPV improves the cost effectiveness and efficiency of screening programmes for cervical carcinoma. METHOD USED: Real time qualitative polymerase c ..read more

MYD88 P.L265P MUTATION ANALYSIS Home Mouth Cancer MYD88 P.L265P MUTATION ANALYSIS MUTATION TESTED: MYD88 p. L265P INDICATIONS FOR ORDERING: Diagnostic in cases of lymphoplasmacytic lymphoma, Waldenstroms Macroglobulinemia. It is also found in 70% cases of Primary testicular diffuse large B cell ymphomas and in a few cases of Primary central nervous system lymphoma. METHOD USED: Allele-specific oligonucleotide polymerase chain reaction for the detection of MYD88 p.L265P mutation analysis SPECIMENS – Type, storage and transport Type: Non-diluted peripheral blood sample ..read more

Odontogenic ossifying fibroma is a rare benign odontogenic neoplasm that is most commonly found in the mandibular / premolar region of female patients in the second to fourth decades of life. A 47 years old female from Kenya, without any co-morbidities, presented to RGCIRC in the year 2022 with the complaints of swelling in the mandible for 2 years. She was evaluated by the oncology team and was diagnosed with an odontogenic tumor of the central arch of the mandible. She underwent wide local excision surgery and reconstruction by free fibula flap. Her postoperative recovery was adequate and un ..read more