Larger spleens and greater splenic contraction during exercise may be an adaptive characteristic of Nepali Sherpa at high‐altitude
Wiley Online Library » American Journal of Human Biology
by Tom D. Brutsaert, Taylor Shay Harman, Abigail W. Bigham, Anne Kalker, Kelsey C. Jorgensen, Kimberly T. Zhu, Bethany C. Steiner, Ella Hawkins, Trevor A. Day, Ajaya J. Kunwar, Nilam Thakur, Sunil Dhungel, Nima Sherpa, Pontus K. Holmström
1w ago
Abstract Objectives The Sherpa ethnic group living at altitude in Nepal may have experienced natural selection in response to chronic hypoxia. We have previously shown that Sherpa in Kathmandu (1400 m) possess larger spleens and a greater apnea-induced splenic contraction compared to lowland Nepalis. This may be significant for exercise capacity at altitude as the human spleen responds to stress-induced catecholamine secretion by an immediate contraction, which results in transiently elevated hemoglobin concentration ([Hb]). Methods To investigate splenic contraction in response to exercise at ..read more
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Wiley Online Library » American Journal of Human Biology
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1w ago
American Journal of Human Biology, Volume 36, Issue 5, May 2024 ..read more
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Generational trends in the transition to womanhood in lowland rural Nepal: Changes in the meaning of early marriage
Wiley Online Library » American Journal of Human Biology
by A. Marphatia, L. Busert‐Sebela, D. S. Manandhar, A. Reid, M. Cortina‐Borja, N. Saville, M. Dahal, M. Puri, J. C. K. Wells
2w ago
Abstract Objective In South Asia, studies show secular trends toward slightly later women's marriage and first reproduction. However, data on related biological and social events, such as menarche and age of coresidence with husband, are often missing from these analyses. We assessed generational trends in key life events marking the transition to womanhood in rural lowland Nepal. Methods We used data on 110 co-resident mother-in-law (MIL) and daughter-in-law (DIL) dyads. We used paired t-tests and chi-squared tests to evaluate generational trends in women's education, and mean age at menarche ..read more
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Quantitative and qualitative analysis of stability for 16 serum immunoregulators over 50 freeze–thaw cycles
Wiley Online Library » American Journal of Human Biology
by R. N. Chowdhury, A. Armato, E. Culver, L. Shteynman, C. Kurien, B. Cradin, F. Margolin, T. Nguyen, C. Cardona, N. Kabir, R. M. Garruto, J. K. Lum, K. Wander
2w ago
Abstract Objectives To evaluate the reliability of data from the assay of bio-archived specimens, a 50-freeze–thaw-cycle (FTC) degradation study of fresh sera was conducted to test the stability of 16 immunoregulators. Methods Twenty de-identified serum specimens were obtained from volunteers at United Health Services-Wilson Memorial Hospital. Specimens were stored at −20°C and underwent daily 1 h thawing and subsequent freezing for each FTC over 50 consecutive days. Immunoregulator concentrations were assessed via enzyme-linked immunosorbent assay (ELISA) in participant samples at 2 FTC (base ..read more
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Allostatic load, adverse childhood experiences, executive functions, and BMI status in adolescents and young adults
Wiley Online Library » American Journal of Human Biology
by Anna Prunell‐Castañé, Maite Garolera, Jonatan Ottino‐González, María Ángeles Jurado
3w ago
Abstract Objectives Chronic stress induces preclinical changes in the metabolic, cardiovascular, and immune systems. This phenomenon, known as allostatic load (AL), can impair executive functions (EF), which may be even more affected in individuals with excess weight due to their characteristic inflammatory state and cardiometabolic changes. Adverse childhood experiences (ACEs) contribute to AL and may influence executive functioning presumably via alterations within the hypothalamic–pituitary axis, including epigenetic modifications. We assess the relationship between AL and EF in youth with ..read more
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Is there an association between proficiency in fundamental movement skills and mderate‐to‐vigorous physical activity in childhood on weekdays and weekends? The REACT project
Wiley Online Library » American Journal of Human Biology
by Fernando Garbeloto, José Maia, Tiago V. Barreira, Donald Hedeker, Jean‐Philippe Chaput, Rui Garganta, Cláudio Farias, Ricardo Santos, David F. Stodden, Go Tani, Peter T. Katzmarzyk, Sara Pereira
1M ago
Abstract Objective The present study probes into the association between children's fundamental movement skills (FMS) and moderate-to-vigorous physical activity (MVPA) during weekdays and weekends. Methods This cross-sectional sample included 1014 children aged 6–10 years from the REACT project. Physical activity was assessed with accelerometry, and five FMS (stationary dribble, kick, catch, overhand throw, and underhand roll) were assessed with the digital platform Meu Educativo®. Three groups were formed based on the frequency of FMS that each child mastered: group 1 (wizard level in four or ..read more
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Perception of uncontrollable mortality risk is associated with food insecurity and reduced economic effort among resource‐insecure college students during COVID‐19
Wiley Online Library » American Journal of Human Biology
by Casey J. Roulette, Miriam Kopels
1M ago
Abstract In the framework of the uncontrollable mortality risk hypothesis, resource scarcity intersects with mortality risk, shaping resource allocation strategies with enduring impacts on human health and wellbeing. Despite rising economic and food insecurity among US college students, little is known about how these insecurities relate to mortality risk, or how scarcity and mortality risk interact to shape college students' resource allocation strategies. We examine perceptions of resource scarcity and mortality risk and their associations with food insecurity and resource allocation strateg ..read more
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Age at peak height velocity in Polish adolescents: Effect of socioeconomic factors
Wiley Online Library » American Journal of Human Biology
by Aleksandra Gomula, Natalia Nowak‐Szczepanska, Miroslav Králík, Robert M. Malina, Monika Zaręba, Slawomir Koziel
1M ago
Abstract Age at peak height velocity (APHV) is an indicator of maturity timing which is applicable to both sexes, and which is influenced by environmental factors. The objective of this study was to assess variation in APHV associated with several indicators of socioeconomic status (SES) in a longitudinal sample of Polish adolescents. The sample included 739 boys born in 1983 and followed annually from 12 to 16 years, and 597 girls born in 1985 and followed annually from 9 to 13 years. The height records were fitted with the SITAR model to estimate APHV. SES was estimated using principal compo ..read more
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Wiley Online Library » American Journal of Human Biology
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1M ago
American Journal of Human Biology, Volume 36, Issue 4, April 2024 ..read more
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The change in handgrip strength, after physical exercise, is moderated by digit ratio (2D:4D): A study among the young adults in Poland
Wiley Online Library » American Journal of Human Biology
by Sławomir Kozieł, Jan M. Konarski, Agata Konarska, Joanna Huechert, Zofia Ignasiak, Raja Chakraborty
1M ago
Abstract Background The digit ratio (2D:4D), the ratio of the lengths of second (2D) to the fourth (4D) fingers, is a proxy indicator of prenatal androgen exposure. On average, males display lower 2D:4D than females. Previous studies have shown that lower 2D:4D ratios were associated with better sports and physical abilities. Aim To assess whether a challenge condition, imposed by intense exercise, could increase handgrip strength (HGS) associated with 2D:4D. Methods This cross-sectional experimental study included 90 healthy young Polish adults (40 males, 50 females). They underwent intense p ..read more
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