Phytochemical Profiling and In Vitro Antioxidant, Antimicrobial, Cytotoxicity Effects of Some Glycyrrhiza Species from Turkey
Springer » Pharmaceutical Chemistry Journal
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1w ago
Glycyrrhiza (licorice) species, known as “the grandfather of herbs” is one of the most popular medicinal plants used in traditional medicines and ethnobotany since ancient times. The present study aimed to determine the chemical composition, anti-cancer, antimicrobial and antioxidant activities of Glycyrrhiza glabra L., G. flavescens Boiss., and G. echinata L. taxa from different ecological conditions in Turkey. Root and leaf extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant a ..read more
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Alternative Synthesis of Cobimetinib
Springer » Pharmaceutical Chemistry Journal
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1w ago
A novel approach for synthesis of Cobimetinib was reported, avoiding usage of a strong base in any of the steps with a chiral substrate. An efficient kinetic resolution of racemic key intermediate - tert-butyl 2-(3-hydroxyazetidin-3-yl)piperidine-1-carboxylate with L-tartaric acid was developed, by which enantiopure S-enantiomer was obtained as the corresponding diastereomeric tartrate salt, followed by peptide coupling with 3,4-difluoro-2-(2-fluoro-4-iodo-anilino) benzoic acid in mild conditions and avoiding the use of corresponding haloanhydrides, affording Boc-protected Cobimetinib. In the ..read more
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Sodium Selenite Through Targeting NRF2/STAT3 Pathway Attenuates Testicular Damage in Irradiated Rats
Springer » Pharmaceutical Chemistry Journal
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1w ago
This study proposed that sodium selenite (SSe) could counteract the inflammatory signaling allied with radiation-induced testicular damage. Mature male Sprague-Dawley rats were exposed to a single-dose γ–radiation (5 Gy) and treated with sodium selenite (SSe) daily for nine days. According to the findings, SSe significantly preserved spermatogenesis activity, reducing the levels of the p-STAT3 protein, NF-кB and IL-1, as well as the relative expression of the Nrf2 protein, antioxidant activity, and serum testosterone in irradiated (IRR) rats. In light of this, we can state that, through target ..read more
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Pharmacological Properties of Acetylsalicylic Acid and its Complex with Glycyrrhizic Acid as a Promising Dosage form (Review)
Springer » Pharmaceutical Chemistry Journal
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1w ago
The review summarizes current literature data on the mechanism of antithrombotic, anti-inflammatory, and antipyretic effects of acetylsalicylic acid (ASA), which is widely used in medicine. The use of ASA may be accompanied by several complications from the gastrointestinal tract (ulcers and bleeding), nephrotoxicity, the development of bronchospasm (aspirin triad), and clinical manifestations of aspirin resistance. The advantages and shortcomings of the main methods of preventing undesirable side effects when taking low doses of ASA are considered: the use of proton-pump inhibitors and rebami ..read more
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Comparative GC/MS Analysis, Antioxidant and Anticholinesterase Study for the Alcoholic Extracts of Leaves, Flowers and Bark of Terminalia arjuna (Roxb)
Springer » Pharmaceutical Chemistry Journal
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1w ago
Terminalia arjuna tree is an important plant with massive traditional uses. This study aims to carry out a comparative phytochemical and biological evaluation on the leaves, flowers, and bark of T. arjuna. Phytochemical analysis involved exploration of the methanolic extracts using GC/MS technique as well as quantitative determination of the phenolic and flavonoid contents using Folin–Ciocalteu and AlCl3 reagents, respectively. In vitro biological evaluation of the different extracts as antioxidant and anticholinesterase were studied. Reducing power assay and 2,2-diphenyl-1-picrylhydrazyl (DPP ..read more
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Study of Organ Uptake of the New Hepatotropic Paramagnetic Contrast Agent, the Mn(II) Complex of 2-[2-Carboxymethyl-(4-Hexadecyloxyphenylcarbamoylmethyl)-Aminoethyl]-Aminoethyl-(4-Hexadecyloxyphenylcarbamoylmethyl)-Aminoacetic Acid (Mn-DTPA-GDOF), In Vivo in Some Experimental Models of Liver Damage in Rats
Springer » Pharmaceutical Chemistry Journal
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1w ago
The results of studying magnetic resonance imaging (MRI) of rat liver performed with the original hepatotropic paramagnetic contrast agent (PMCA) Mn-DTPA-GDOF, the Mn(II) complex of 2-[2-carboxymethyl-(4-hexadecyloxyphenylcarbamoylmethyl)-aminoethyl]-aminoethyl-(4-hexadecyloxyphenylcarbamoylmethyl)aminoacetic acid, are presented. Mn-DTPA-GDOF was used as a colloidal solution (0.025 M, pH 8 – 9) with a free Mn(II) content <0.03% and a small excess of DTPA-GDOF (1 – 1.5%). Three groups of seven rats each with hepatitis, cholestatic cholangiohepatitis, and control intact animals were examined ..read more
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Effect of Glycyrrhizic Acid on the Viability of Hela Cervical Adenocarcinoma Cell Line at Different Concentrations of Sex Steroid Hormones
Springer » Pharmaceutical Chemistry Journal
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1w ago
The persistence of human papillomavirus affects the processes of proliferation and differentiation of the stratified squamous epithelium of the cervix with the development of cervical intraepithelial neoplasia and cervical cancer. Hormonal factors have an impact on the process of neoplastic transformation. The aim of this study was an evaluation of the effect of glycyrrhizic acid on the viability of HeLa cervical adenocarcinoma cells at different concentrations of sex steroid hormones. The half-maximal inhibitory concentration (IC50) of glycyrrhizic acid against HeLa cervical adenocarcinoma ce ..read more
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Synthesis, In Silico Analysis, Antibacterial, Radical Scavenging and Antidiabetic Activities of Certain Bis-Azetidinones and Bis-Thiazolidinones
Springer » Pharmaceutical Chemistry Journal
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1w ago
A panel of 1,1-(phenylene)bis[3-chloro-4-(substituted phenyl)azetidin-2-ones] (4a-m) and 3,3′-(1,4-phenylene)bis[2-(substituted phenyl)thiazolidin-4-ones] (5a-m) were synthesized from Schiff base intermediates 3a-m, that were in turn prepared from reaction between p-phenylenediamine and substituted benzaldehydes. The structures of title compounds and intermediates were confirmed by IR, 1H NMR, 13C NMR and mass spectral data. The compounds were screened for antibacterial, DPPH radical scavenging and antidiabetic activities. Compounds 4f and 4a exhibited good antibacterial activity against Gram ..read more
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Peptide Composition and Identification of a Peptide with Anti-Inflammatory and Antiplatelet Properties in Cattle Prostate Extract
Springer » Pharmaceutical Chemistry Journal
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1w ago
An attempt to identify the peptide structure of bovine prostate extract using water/vinegar technology followed by tangential ultrafiltration is described. Protein-peptide components with known functional activity were revealed. A new previously unknown peptide, a fragment of bovine chemokine MCP-1, was selected from the discovered regulatory peptide fragments, synthesized, and tested in three biological assays. The ability of the peptide to suppress the in vitro migration of monocytic cells and platelet aggregation was demonstrated. The newly identified peptide fragment was evaluated as promi ..read more
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Crocin Administration Represses Depressive-Like Behaviors in Rats by Targeting the Hippocampal miRNA-99A/FKBP51/PSD-95 Level
Springer » Pharmaceutical Chemistry Journal
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1w ago
We investigated the role of miR-99a in regulating depressant activity by administering crocin in an animal model of chronic unpredictable mild stress (CUMS). A CUMS rat model was built and crocin was intraperitoneally injected to examine its role in depression-like behaviors. Depression-like behaviors were analyzed using an open-field test (OFT), sucrose preference test (SPT), forced swimming test (FST), and elevated maze test (EPM). Representative depressant activity occurred in CUMS rats. The SPT/OFT/EPM/FST results also indicated that the administration of crocin could reduce depression-lik ..read more
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