Energy Toxicity and Insulin Resistance
The Metabolic Classroom
by Insulin IQ
1w ago
In this episode of The Metabolic Classroom, Dr. Bikman, a biomedical scientist and professor of cell biology, delves into the concept of energy toxicity. He begins by explaining that energy toxicity attempts to explain why certain cells, particularly those capable of storing energy like muscle and liver cells, become insulin resistant. The primary idea is that when these cells accumulate excess energy, particularly in the form of triglycerides, they become resistant to further energy storage by becoming insulin resistant. He clarifies that this is closely related to lipotoxicity, where the st ..read more
Visit website
Sleep and Insulin Resistance
The Metabolic Classroom
by Insulin IQ
1w ago
In this episode of The Metabolic Classroom, Dr. Bikman begins by emphasizing the critical role of insulin in regulating the body’s use of fuel, and influencing whether nutrients are stored or burned. He highlights that food is a primary driver of insulin levels, but other factors like stress and sleep deprivation significantly impact insulin resistance. Stress, often exacerbated by poor sleep hygiene, leads to elevated levels of cortisol and epinephrine, which in turn increase blood glucose levels. Ben explains that going to bed on a full stomach can worsen sleep quality, further contributin ..read more
Visit website
Exogenous Ketones with Dr. Ben Bikman
The Metabolic Classroom
by Insulin IQ
3w ago
In this episode of The Metabolic Classroom, Dr. Bikman explores the history, science, and benefits of ketones, focusing on exogenous ketones. Ben highlights the significant benefits of ketones for brain health. He disputes the common belief that glucose is the brain’s preferred fuel, citing research by Dr. George Cahill that indicates the brain relies heavily on ketones during fasting. The classroom also addresses the evolution and advantages of exogenous ketones. Early forms of exogenous ketones, like ketone salts, had limitations such as mineral imbalance and poor taste. Advances led to th ..read more
Visit website
Heart Health: Fat Matters
The Metabolic Classroom
by Insulin IQ
3w ago
In this episode of The Metabolic Classroom, Dr. Ben Bikman challenges the traditional view that saturated fats are the primary cause of atherosclerotic plaques and heart disease. He asserts that while plaques, or atheromas, in coronary arteries are composed partly of fats and foam cells, the exact process of plaque formation remains speculative. Dr. Bikman emphasizes that anyone claiming to know the definitive cause of plaque formation is likely overstating their knowledge. Foam cells, which are fat-laden macrophages, play a critical role in plaque development and are consistently present at t ..read more
Visit website
Uric Acid with Dr. Ben Bikman
The Metabolic Classroom
by Insulin IQ
1M ago
This episode of The Metabolic Classroom is sponsored by RxSugar. Use this link to get 20% off: https://rxsugar.com/discount/BEN20 02:10 - Overview of Uric Acid: Explanation of what uric acid is and its origins from purine metabolism. 03:16 - Uric Acid and Hyperuricemia: Discussion on uric acid production, excretion, and the condition of hyperuricemia. 05:09 - Gout and Uric Acid Crystallization: How high uric acid levels lead to gout and kidney stones. 07:08 - Importance of Uric Acid in Metabolism: Why uric acid is important, its clinical relevance, and its connection to insulin resistance. 09 ..read more
Visit website
Saturated Fat with Dr. Ben Bikman
The Metabolic Classroom
by Insulin IQ
1M ago
In this episode of The Metabolic Classroom, Professor Ben Bikman, an expert in metabolic research, discusses the debate surrounding saturated fat and its impact on insulin resistance. Dr. Bikman addresses misconceptions about saturated fat perpetuated by proponents of plant-based diets, who often blame meat-based saturated fats for insulin resistance. He refers to his own 2011 research, highlighting the role of toll-like receptor four (TLR4) activation in inducing inflammation and insulin resistance, particularly stimulated by saturated fats. Acknowledging limitations in his earlier work, Dr ..read more
Visit website
The Metabolism of Male Infertility
The Metabolic Classroom
by Insulin IQ
2M ago
Dr. Ben Bikman discusses the intricate relationship between metabolic health and male infertility. While metabolic health is often associated with conditions like obesity and diabetes, Dr. Bikman emphasizes its relevance to less obvious issues like male infertility. He notes that while the processes of reproduction differ between the sexes, they share a common metabolic core. Ben highlights that infertility affects approximately 15% of couples trying to conceive, with men contributing to around 30% of cases. He explains the role of hormones like follicle-stimulating hormone (FSH) and luteini ..read more
Visit website
The Metabolism of Female Infertility
The Metabolic Classroom
by Insulin IQ
2M ago
In this lecture, Professor Ben Bikman delves into the metabolic aspects of female infertility, specifically focusing on the influence of insulin resistance. He begins by highlighting the high prevalence of infertility among women of reproductive age, with up to 15% affected globally, and particularly prevalent in regions with high rates of insulin resistance, such as Sub-Saharan Africa, South Asia, and the Middle East. Insulin resistance, a condition where cells become less responsive to insulin, plays a crucial role in female infertility. Dr. Bikman explains that insulin resistance manifests ..read more
Visit website
Fatty Liver Disease with Dr. Ben Bikman
The Metabolic Classroom
by Insulin IQ
2M ago
In this Metabolic Classroom episode, Dr. Bikman delves into the intricate dynamics of fatty liver disease, a prevalent metabolic problem affecting millions worldwide. Describing the liver as the “soccer mom” of metabolism due to its involvement in various metabolic processes, Ben emphasizes the liver’s central role in nutrient metabolism, particularly in handling fats. Fatty liver disease, once primarily associated with alcohol consumption, has now become a widespread issue driven by metabolic factors. It progresses from simple fat accumulation to inflammation (non-alcoholic steatohepatitis o ..read more
Visit website
Strategies for Fat Burning with Dr. Ben Bikman
The Metabolic Classroom
by Insulin IQ
2M ago
In this lecture from the Metabolic Classroom, Dr. Ben Bikman, a biomedical scientist specializing in metabolism, delves into various strategies for fat loss. He begins by highlighting the importance of understanding fat tissue dynamics, focusing particularly on hormones, drugs, and sex-specific effects. The main topic for the lecture is strategies for fat loss, which Bikman divides into three categories: drugs, surgical interventions, and lifestyle changes. Bikman briefly revisits the topic of drugs for fat loss, emphasizing GLP-1 agonists and their mechanism of action in reducing cravings ..read more
Visit website

Follow The Metabolic Classroom on FeedSpot

Continue with Google
Continue with Apple
OR