Increased levels of circulating soluble CD226 in multiple sclerosis
SAGE Journals » Multiple Sclerosis Journal
by Saniya Kari, Florence Bucciarelli, Thibault Angles, Anne-Cecile Oster, Pauline Cauboue, Karl Laviolette, Madeline Mougenot, Elena Morandi, Isabelle Bernard, Beatrice Pignolet, Chloé Bost, Joelle Thomas, Leonor Nogueira, Abdelhadi Saoudi, Roland Liblau, Anne L Astier
2d ago
Multiple Sclerosis Journal, Ahead of Print. Background:The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases such as multiple sclerosis (MS) are unknown.Objective:To investigate the presence and functional implications of sCD226 in persons with multiple sclerosis (pwMS) and other neurological diseases.Methods:The mechanisms of sCD226 production were first investigated by analyzing CD226 surface expression levels and supernatants o ..read more
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Neoehrlichiosis associated with ocrelizumab in a patient with multiple sclerosis: A case report
SAGE Journals » Multiple Sclerosis Journal
by Raja Majid Afzal, Jeppe Romme Christensen, Rosa Maja Møhring Gynthersen, Anne-Mette Lebech, Morten Blinkenberg, Helene Mens
2d ago
Multiple Sclerosis Journal, Ahead of Print. Objective:To describe a case of neoehrlichiosis, an emerging opportunistic tick-borne infection, in a patient with multiple sclerosis (MS) treated with ocrelizumab.Methods:This is a case study.Results:Our patient developed clinical infection over several months while on ocrelizumab and was ultimately diagnosed with neoehrlichiosis, caused by the bacteria Neoehrlichia mikurensis. Resolution of symptoms began within a few days after the initiation of antibiotic treatment.Conclusion:We describe the first probable case of ocrelizumab-associated neoehrlic ..read more
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Reply: Mobile health interventions in multiple sclerosis: A systematic review
SAGE Journals » Multiple Sclerosis Journal
by Christoph Heesen, Dagmar Lühmann
2d ago
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BCG vaccination and multiple sclerosis risk: A Norwegian cohort study
SAGE Journals » Multiple Sclerosis Journal
by Ola Nakken, Jan Harald Aarseth, Stig Wergeland, Hein Stigum, Haakon E Meyer, Trygve Holmøy
4d ago
Multiple Sclerosis Journal, Ahead of Print. Introduction:Bacillus Calmette–Guérin (BCG) vaccination induces long-lasting effects on the adaptive and innate immune systems and prevents development of experimental autoimmune encephalomyelitis and possibly also inflammatory disease activity in multiple sclerosis (MS).Objective:The objective is to examine if BCG given in early adulthood decreases MS risk.Methods:From 791,369 (52% females) Norwegians participating in a national tuberculosis screening program from 1963 to 1975, we collected information on BCG vaccination and tuberculosis disease sta ..read more
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The impact of social distancing measures on anti–JC virus serostatus changes before and during the COVID-19 pandemic in US patients with multiple sclerosis
SAGE Journals » Multiple Sclerosis Journal
by Stephen C Krieger, Susie Sinks, Furong Huang, Julie Steverson, Tamar J Kalina, Kurt White, Robin L Avila
4d ago
Multiple Sclerosis Journal, Ahead of Print. Background:The coronavirus disease 2019 (COVID-19) pandemic offered an epidemiological opportunity to evaluate if isolation and masking affected John Cunningham (JC) virus transmission.Objective:This study aimed to assess the proportion of natalizumab-treated patients who converted to a positive anti-JCV antibody serostatus before and during the pandemic.Methods:Data from TYSABRI Outreach: Unified Commitment to Health (TOUCH) for 22,375 US patients treated with natalizumab with anti-JCV antibody records were assessed in epochs annually from 2017 to 2 ..read more
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T1/T2-weighted ratio: A feasible MRI biomarker in multiple sclerosis
SAGE Journals » Multiple Sclerosis Journal
by Mateus Boaventura, Jaume Sastre-Garriga, Carolina de Medeiros Rimkus, Àlex Rovira, Deborah Pareto
1w ago
Multiple Sclerosis Journal, Ahead of Print. T1/T2-weighted ratio is a novel magnetic resonance imaging (MRI) biomarker based on conventional sequences, related to microstructural integrity and with increasing use in multiple sclerosis (MS) research. Different from other advanced MRI techniques, this method has the advantage of being based on routinely acquired MRI sequences, a feature that enables analysis of retrospective cohorts with considerable clinical value. This article provides an overview of this method, describing the previous cross-sectional and longitudinal findings in the main MS ..read more
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Psoriasisform dermatitis following anti-CD20 therapies: Immunologic lessons and management dilemmas
SAGE Journals » Multiple Sclerosis Journal
by Steffen Pfeuffer
1w ago
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Psoriasiform dermatitis following ocrelizumab in relapsing-remitting multiple sclerosis: Case report and literature review
SAGE Journals » Multiple Sclerosis Journal
by Callanan Emma, Petkova Vesela, Polly Kay, Huseyin Huseyin, Hassett Alison, Sittampalam Mara, De Angelis Floriana, Collorone Sara
1w ago
Multiple Sclerosis Journal, Ahead of Print. We present a case of a 30-year-old man with relapsing-remitting multiple sclerosis who developed psoriasiform dermatitis following his second course of ocrelizumab. This resolved with topical therapies and discontinuation of treatment. Cases of psoriasiform rashes have been increasingly reported in the use of ocrelizumab and are possibly due to B-cell (CD20) depletion and T-cell overregulation. Nevertheless, skin-related adverse reactions are not yet considered in the risk management plans of anti-CD20 treatments in multiple sclerosis ..read more
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Responsiveness to pembrolizumab in severe early-onset natalizumab associated PML-IRIS in patient with relapsing-remitting multiple sclerosis
SAGE Journals » Multiple Sclerosis Journal
by Merve Bahar Ercan, Belgin Kocer, Taylan Altiparmak, Ilker Arslan
1w ago
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A US payer perspective health economic model assessing value of monitoring disease activity to inform discontinuation and re-initiation of DMT in multiple sclerosis
SAGE Journals » Multiple Sclerosis Journal
by Kian Jalaleddini, Robert A Bermel, Bari Talente, David Weinstein, Ferhan Qureshi, Maital Rasmussen, Sreeranjani Menon, Miyuru Amarapala, Kesshi Jordan, Ati Ghoreyshi, Shannon McCurdy, Mike Edgeworth
1w ago
Multiple Sclerosis Journal, Ahead of Print. Objectives:We evaluate the potential clinical and cost impacts of discontinuing disease-modifying therapy (DMT) in people with multiple sclerosis (PwMS) when age-related immunosenescence can reduce DMT efficacy while increasing associated risks.Methods:A Markov model simulated clinical and cost impacts to the patient and payers when a proportion of eligible patients with relapsing remitting multiple sclerosis (RRMS) discontinue DMT. Eligibility was defined as age >55 years, an RRMS diagnosis of >5 years, and no history of relapses for 5 years ..read more
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