Wiley Online Library » Health Science Reports
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Health Science Reports is an international, open access journal that publishes research and commentaries from across all medical and health sciences disciplines . The journal welcomes clinical studies, as well as reports on methods and research design, health services, public health, and medical education and practice.
Wiley Online Library » Health Science Reports
2d ago
Abstract Background and Aims
The effectiveness of immune checkpoint inhibitors (ICIs) in low programmed death ligand 1 (PD-L1) expression in cervical cancer (CC) patients remains unknown. We aimed to evaluate the efficacy of ICIs in low PD-L1 expression CC patients.
Methods
The study is an individual patient data (IPD)-based meta-analysis. IPD were compiled through KMSubtraction and IPDfromKM methodologies from high-quality randomized clinical trials and single-arm studies which reported overall survival (OS) or progression-free survival (PFS) stratified by PD-L1 expression. Kaplan−Meier ..read more
Wiley Online Library » Health Science Reports
2d ago
Abstract Background and Aims
As the fastest-growing neurological disorder globally, a better understanding of Parkinson's disease (PD) is needed to improve patient outcomes and reduce the increasing economic and healthcare burden associated with the disease. Whilst classified as a movement disorder, this disease is highly heterogeneous, encompassing a broad range of both motor and non-motor symptoms (NMS). Cognitive impairment, presenting as either mild cognitive impairment or PD-dementia, is one of the most prevalent and disabling NMS. To better understand heterogeneity in PD, researchers hav ..read more
Wiley Online Library » Health Science Reports
2d ago
Abstract Background
In underdeveloped nations like Ethiopia, severe acute malnutrition (SAM) is one of the most pressing public health issues. Despite efforts to pinpoint the causes of SAM, the impact of parents' drug usage on their children's nutritional status remains unclear and unresolved.
Objective
The purpose of this research was to determine the risk factors for SAM in children under five who were attending medical facilities in the Leqa Dulacha district.
Materials and Methods
A health facility-based case-control study was carried out from March 1 to July 30, 2022, with 256 children und ..read more
Wiley Online Library » Health Science Reports
2d ago
Abstract Background and Aims
The “hypervirulent” variant of Klebsiella pneumoniae (hvKp) is an emerging pathogen that cause life-threatening infection. The present study was conducted to identify the prevalence of hvKp and to investigate the presence class 1, 2, and 3 integrons in these isolates.
Methods
A cross-sectional study was conducted at three teaching hospitals, Ahvaz, South-west of Iran, from January 1, 2019 to December 31, 2020. Samples were collected from inpatients and included only the first samples collected from each patient. K. pneumoniae strains were isolated from different sp ..read more
Wiley Online Library » Health Science Reports
2d ago
Health Science Reports, Volume 7, Issue 5, May 2024 ..read more
Wiley Online Library » Health Science Reports
2d ago
Health Science Reports, Volume 7, Issue 5, May 2024 ..read more
Wiley Online Library » Health Science Reports
2d ago
Abstract Background and Aim
It is essential that healthcare providers display ethical behavior toward their patients. Despite development of codes of ethics for clinical practice, the occurrence of unethical behaviors toward patients is alarmingly high. The present study was conducted to identify the barriers to ethical treatment of patients in clinical environments.
Methods
Through systematic narrative review, the present study investigated the barriers to ethical treatment of patients. This study was carried out in line with Assessment of Multiple Systematic Reviews 2 and Preferred Reporting ..read more
Wiley Online Library » Health Science Reports
2d ago
Abstract Background and Aims
Vital sign monitoring needs to be timely and correct to recognize deteriorating patients early and trigger the relevant clinical response. The aim of this study is to retrospectively evaluate compliance specifically toward the regional vital sign monitoring protocol the so called early warning score protocol (EWS-protocol) 72 h before a medical emergency team response (MET-response) and thereby illuminate whether poor compliance translates into a worse patient outcome.
Methods
It was investigated all eligible patients that underwent MET responses during t ..read more
Wiley Online Library » Health Science Reports
2d ago
Abstract Background and Aims
Emergence of multidrug resistance in non-fermenting Gram-negative bacilli is a threat to public health. Combination therapy is a strategy for the treatment of antibiotic-resistant infections.
Methods
In this cross-sectional study, a total of 63 nonduplicate clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa were collected from various specimens. Identification of bacterial isolates was performed by phenotypic and molecular tests. Antibiotic susceptibility patterns and detection of β-lactamase genes were determined using the broth microdilu ..read more
Wiley Online Library » Health Science Reports
2d ago
Abstract Background and Aims
Mounting evidence highlights a strong association between chronic pancreatitis (CP) and type 2 diabetes (T2D), although the exact mechanism of interaction remains unclear. This study aimed to investigate the crosstalk genes and pathogenesis between CP and T2D.
Methods
Transcriptomic gene expression profiles of CP and T2D were extracted from Gene Expression Omnibus, respectively, and the common differentially expressed genes (DEGs) were subsequently identified. Further analysis, such as Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein–prot ..read more