SAGE Publications » International Journal of Stroke
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International Journal of Stroke is the official publication of the World Stroke Organization. It provides a significant contribution to the international stroke research community by concentrating on both the clinical aspects of stroke from around the world as well as basic science contributions in areas of clinical interest.
SAGE Publications » International Journal of Stroke
1d ago
International Journal of Stroke, Ahead of Print.
Background:Patients with acute ischemic stroke with a large vessel occlusion (LVO) admitted to non endovascular-capable centers often require inter-hospital transfer for thrombectomy. We aimed to describe the incidence of substantial clinical change during transfer, the factors associated with clinical change, and its relationship with 3-month outcome.Methods:We analyzed data from two cohorts of acute stroke patients transferred for thrombectomy to a comprehensive center (Stanford, USA, November 2019 to January 2023; Montpellier, France, January ..read more
SAGE Publications » International Journal of Stroke
5d ago
International Journal of Stroke, Ahead of Print.
Background:Stroke is the second leading cause of death and the leading cause of disability worldwide. However, how the prevalence of stroke varies across the world is uncertain.Aims:The aim of this study was to analyze temporal trends of prevalence for stroke, including ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) at the global, regional, and national levels.Methods:The age-standardized prevalence rates (ASPR) of stroke, IS, ICH, and SAH, along with their corresponding 95% uncertainty intervals (UI), we ..read more
SAGE Publications » International Journal of Stroke
1w ago
International Journal of Stroke, Ahead of Print.
Background:Secondary prevention interventions to reduce post-stroke cognitive impairment (PSCI) can be aided by the early identification of high-risk individuals who would benefit from risk factor modification.Aims:To develop and evaluate a predictive model to identify patients at increased risk of PSCI over 5 years using data easily accessible from electronic health records.Methods:Cohort study that included primary care patients from two academic medical centers. Patients were aged 45 years or older, without prior stroke or prevalent cognitive ..read more
SAGE Publications » International Journal of Stroke
1w ago
International Journal of Stroke, Ahead of Print.
Background:Recent randomized trials have shown the benefit of mechanical thrombectomy (MT) also in patients with an established large ischemic core.Aims:The purpose of this study was to define baseline predictors of clinical outcome in patients with large vessel occlusion (LVO) in the anterior circulation and an Alberta Stroke Program Early CT score (ASPECTS) ⩽ 5, undergoing MT.Material and methods:The databases of 16 comprehensive stroke centers were retrospectively screened for patients with LVO and ASPECTS ⩽5 that received MT. Baseline clinic ..read more
SAGE Publications » International Journal of Stroke
1w ago
International Journal of Stroke, Ahead of Print.
Background:Fatigue is a common symptom in cerebral small vessel disease (SVD), but its pathogenesis is poorly understood. It has been suggested that inflammation may play a role. We determined whether central (neuro) inflammation and peripheral inflammation were associated with fatigue in SVD.Methods:Notably, 36 patients with moderate-to-severe SVD underwent neuropsychometric testing, combined positron emission tomography and magnetic resonance imaging (PET–MRI) scan, and blood draw for the analysis of inflammatory blood biomarkers. Microglial s ..read more
SAGE Publications » International Journal of Stroke
1w ago
International Journal of Stroke, Ahead of Print.
Background:Post-stroke emotionalism affects one in five stroke sufferers 6 months after their stroke, but despite its frequency remains a poorly understood stroke symptom. The literature is limited, especially compared to other frequently observed neurological conditions such as aphasia and visual neglect.Aim and Methods:This narrative review presents a summary of the post-stroke emotionalism literature, to inform clinical practice and future research. We cover discussion of definitions, prevalence, neurobiology, predisposing and precipitating f ..read more
SAGE Publications » International Journal of Stroke
1w ago
International Journal of Stroke, Ahead of Print.
Background:Patients with large vessel occlusion (LVO) stroke presenting with milder baseline clinical severity are common and require endovascular thrombectomy. However, such patients are difficult to recognize using pre-hospital severity-based triage tools and therefore are likely to require a secondary inter-hospital transfer if transported to a non-thrombectomy center. Given the potential for milder severity to represent better underlying cerebrovascular collateral circulation, it is unknown whether transfer delays are still associated with p ..read more
SAGE Publications » International Journal of Stroke
2w ago
International Journal of Stroke, Ahead of Print.
Background:Due to the rarity of cerebral venous thrombosis (CVT), performing high-quality scientific research in this field is challenging. Providing answers to unresolved research questions will improve prevention, diagnosis, and treatment, and ultimately translate to a better outcome of patients with CVT. We present an international research agenda, in which the most important research questions in the field of CVT are prioritized.Aims:This research agenda has three distinct goals: (1) to provide inspiration and focus to research on CVT for th ..read more
SAGE Publications » International Journal of Stroke
2w ago
International Journal of Stroke, Ahead of Print.
Background:Three large randomized controlled trials of fluoxetine for stroke recovery have been performed. We performed an individual patient data meta-analysis (IPDM) on the combined data.Methods:Fixed effects meta-analyses were performed on the combined data set, for the primary outcome (modified Rankin scale (mRS) at 6 months), and secondary outcomes common to the individual trials. As a sensitivity analysis, summary statistics from each trial were created and combined.Findings:The three trials recruited a combined total of 5907 people (mean ..read more
SAGE Publications » International Journal of Stroke
3w ago
International Journal of Stroke, Ahead of Print.
Background:Patent foramen ovale (PFO) is a congenital anatomical variant which is associated with strokes in young adults. Contrary to vascular risk factors and atherosclerosis, a PFO is present from birth. However, it is completely unknown how an anatomical structure that is already present at birth in a large proportion of the population can convert into a PFO that causes stroke in a few. Recent studies reported a significant association between certain trigger factors and ischemic stroke in young adults. This study aims to investigate these t ..read more