Wiley Online Library » The Journal of Dermatology
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The Journal of Dermatology is the official peer-reviewed publication of the Japanese Dermatological Association and the Asian Dermatological Association. The journal aims to provide a forum for the exchange of information about new and significant research in dermatology and to promote the discipline of dermatology in Japan and throughout the world. Research articles are supplemented by..
Wiley Online Library » The Journal of Dermatology
19h ago
The Journal of Dermatology, EarlyView ..read more
Wiley Online Library » The Journal of Dermatology
19h ago
The Journal of Dermatology, EarlyView ..read more
Wiley Online Library » The Journal of Dermatology
19h ago
Abstract
Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation-induced cSCC with a high level of tumor-mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation-induced cSCC, even at advanced stages ..read more
Wiley Online Library » The Journal of Dermatology
19h ago
The Journal of Dermatology, EarlyView ..read more
Wiley Online Library » The Journal of Dermatology
19h ago
The Journal of Dermatology, EarlyView ..read more
Wiley Online Library » The Journal of Dermatology
3d ago
Abstract
The Index for Facial Angiofibromas (IFA), a novel scoring system for angiofibromas, has been validated in patients with tuberous sclerosis complex (TSC). The objective of this analysis was to further validate the IFA using data from a clinical trial of topical sirolimus in patients with TSC. This was an analysis of photographs from a Phase III trial conducted in Japan (NCT02635789). Patients (n = 62) were randomized 1:1 to receive sirolimus or placebo gel for 12 weeks. Changes in angiofibromas were independently assessed using the primary composite endpoint, the Facial Angiofibroma Se ..read more
Wiley Online Library » The Journal of Dermatology
3d ago
The Journal of Dermatology, EarlyView ..read more
Wiley Online Library » The Journal of Dermatology
3d ago
Abstract
Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated t ..read more
Wiley Online Library » The Journal of Dermatology
3d ago
The Journal of Dermatology, EarlyView ..read more
Wiley Online Library » The Journal of Dermatology
4d ago
The Journal of Dermatology, EarlyView ..read more