Journal of Diabetes, Volume 16, Issue 4, April 2024 ..read more

Highlights What are the new findings? This was the first Australian study using real-world data to show SGLT-2is reduce ARF and CKD compared to DPP-4is in people with type 2 diabetes. The rates of hospital admissions for ARF and CKD in people with type 2 diabetes were 22% and 17% lower, respectively, among SGLT-2i initiators compared to DPP-4i initiators. How might this have an impact on clinical practice in the foreseeable future? Our study suggests that benefits of SGLT-2is apparent in clinical trials, in preventing acute and chronic renal events in people with type 2 diabetes, are reflecte ..read more

Highlights Kisspeptins (KPs) were first discovered to have antimetastatic action. Historically, a role in reproduction was demonstrated. Today, there is growing experimental and clinical evidence that KPs and their receptors regulate metabolism. Disruption of KP and receptor interaction provides an interesting approach to treating metabolic conditions, as well as reproductive disorders. Clinical trials have focused mainly on treating reproductive dysfunctions; however, greater understanding of the biology and mechanisms of action of KPs is being used in the therapeutic armory against insulin ..read more

Highlights Type 1 diabetes (T1D) patients with depression were characterized by unique profiles of gut microbiota and serum metabolites. Phascolarctobacterium, Butyricimonas, and Alistipes could predict the risk of T1D with depression. Abstract Background Depression is the most common psychological disorder in patients with type 1 diabetes (T1D). However, the characteristics of microbiota and metabolites in these patients remain unclear. This study aimed to investigate microbial and metabolomic profiles and identify novel biomarkers for T1D with depression. Methods A case–control study was c ..read more

Highlights At present, the traditional and emerging strategies using hepatocyte-derived islet-like cells for diabetic cell replacement therapy have made extensive and far-reaching progress. Gene reprogramming and chemical reprogramming technology are traditional strategies with potential, and organoid technology as an emerging strategy has also been widely studied. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing also provides new opportunities and challenges for the development of organoid technology. Abstract Although pancreas and islet cell transplantat ..read more

Journal of Diabetes, Volume 16, Issue 4, April 2024 ..read more

Highlights Women diagnosed with gestational diabetes were significantly more likely to develop renal disease, have a major cardiovascular event, and develop hypertension and dyslipidemia following delivery compared with women without diabetes in pregnancy. The risk of developing type 2 diabetes for these women remains 20 times higher than for women without diabetes in pregnancy, despite knowledge of this association for over 50 years. European women diagnosed with gestational diabetes have the highest risk of developing type 2 diabetes compared with Māori, Pacific, and Asian women. Abstract ..read more

Highlights With the increase of heart rate (HR) level, high levels HR was associated with increasing risk of type 2 diabetes mellitus (T2DM). HR was in interaction with obesity, associating with incidence of T2DM in diabetic patients with HR < 74 beats/min. HR could be used as an independent assessment factor for diabetic patients with HR > 88 beats/min. Abstract Background Although obesity and heart rate (HR) were closely related to the prevalence and development of type 2 diabetes mllitus (T2DM), few studies have shown a co-association effect of them on T2DM. We aimed at assessing th ..read more

Highlights Patients with ear lobe crease (ELC) are more likely to have carotid artery lesions stroke and coronary heart disease. Skin autofluorescence advanced glycation end products (SAF-AGEage) was associated with the prevalence of ELC. Abstract Objective Several studies have demonstrated a significant association between the presence of the ear lobe crease (ELC) and cardiovascular disease. Advanced glycation end-products (AGEs) can affect the structures and functions of proteins and contribute to the development of diabetic complications. However, few studies have reported the relationshi ..read more

Highlights This large cohort study investigated a potential association between sleep pattern and acute myocardial infarction mortality among individuals with diabetes. Healthy sleep score showed a linear relationship with acute myocardial infarction mortality among people with diabetes. Of five sleep habits, adequate sleep duration was associated with lowest risk of acute myocardial infarction mortality. Abstract ..read more