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Response to treatment in psoriatic arthritis, the effect of age: analysis of patients receiving ustekinumab in the PsABio real-world study

BMC » Arthritis Research & Therapy

by Laure Gossec, Elke Theander, Soumya D. Chakravarty, Paul Bergmans, Frederic Lavie, Wim Noël, Mohamed Sharaf, Stefan Siebert and Josef S. Smolen

12h ago

This post-hoc analysis of PsABio (NCT02627768) evaluated safety, effectiveness and treatment persistence in patients ..read more

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Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data

BMC » Arthritis Research & Therapy

by Raquel Ena María Granados, M. Lourdes Ladehesa-Pineda, M. Ángeles Puche-Larrubia, Alejandro Escudero-Contreras, Maxime Dougados, Eduardo Collantes-Estevez and Clementina López-Medina

1d ago

In axial spondyloarthritis (axSpA), peripheral SpA (pSpA) and psoriatic arthritis (PsA), enthesitis is a hallmark clinical feature that can be assessed by the SPARCC index, LEI, MASES and MEI. These indices ev ..read more

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Role of high-temperature requirement serine protease A 2 in rheumatoid inflammation

BMC » Arthritis Research & Therapy

by Gi Heon Jeong, Min-Kyung Nam, Wonhee Hur, Seolhee Heo, Saseong Lee, Eunbyeol Choi, Jae Hyung Park, Youngjae Park, Wan-Uk Kim, Hyangshuk Rhim and Seung-Ah Yoo

1d ago

High-temperature requirement serine protease A 2 (HtrA2) is known to be involved in growth, unfolded protein response to stress, apoptosis, and autophagy. However, whether HtrA2 controls inflammation and immun ..read more

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Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis

BMC » Arthritis Research & Therapy

by Janni Maria Pedersen, Aida Solhøj Hansen, Cæcilie Skejø, Kristian Juul-Madsen, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Bjarne Kuno Møller, Lene Dreyer, Ellen-Margrethe Hauge, Malene Hvid, Stinne Greisen and Bent Deleuran

1d ago

Lymphocyte activation gene-3 (LAG-3) inhibits T cell activation and interferes with the immune response by binding to MHC-II. As antigen presentation is central in rheumatoid arthritis (RA) pathogenesis, we st ..read more

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Sex and age do not modify the association between glucocorticoids and bone mineral density in patients with rheumatoid arthritis: a cross-sectional study

BMC » Arthritis Research & Therapy

by Andriko Palmowski, Zhivana Boyadzhieva, Sabrina M. Nielsen, Burkhard Muche, Sandra Hermann, Maarten Boers, Henning Bliddal, Robin Christensen, Edgar Wiebe and Frank Buttgereit

1d ago

It is unclear whether sex or age modify the association of glucocorticoid (GC) use with reduced bone mineral density (BMD) in patients with rheumatoid arthritis (RA ..read more

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Examining the influence of pain neuroscience education followed by a Pilates exercises program in individuals with knee osteoarthritis: a pilot randomized controlled trial

BMC » Arthritis Research & Therapy

by Pouya Rabiei, Bahram Sheikhi and Amir Letafatkar

3d ago

Knee osteoarthritis (OA) is a multifactorial form of rheumatic condition contributing to physical and psychological factors. Treatments have been provided solely and often compared with each other. An alternat ..read more

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Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis

BMC » Arthritis Research & Therapy

by Sophie Hecquet, Perle Totoson, Hélène Martin, Marie-Paule Algros, Philippe Saas, Jean-Paul Pais-de-Barros, Alban Atchon, Benoît Valot, Didier Hocquet, Maude Tournier, Clément Prati, Daniel Wendling, Céline Demougeot and Frank Verhoeven

3d ago

Intestinal inflammation, dysbiosis, intestinal permeability (IP), and bacterial translocation (BT) have been identified in patients with spondyloarthritis but the time at which they appear and their contributi ..read more

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Real-life drug retention rate and safety of rituximab when treating rheumatic diseases: a single-centre Swiss retrospective cohort study

BMC » Arthritis Research & Therapy

by Alexandre Dumusc, Fahad Alromaih, Matthieu Perreau, Thomas Hügle, Pascal Zufferey and Diana Dan

1w ago

In Switzerland, rituximab (RTX) is licenced for the treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitis (AAV) but is frequently used off-label to treat other auto-immune diseases (AID), espec ..read more

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Identification of the immune-related biomarkers in Behcet’s disease by plasma proteomic analysis

BMC » Arthritis Research & Therapy

by Huan Liu, Panpan Zhang, Fuzhen Li, Xiao Xiao, Yinan Zhang, Na Li, Liping Du and Peizeng Yang

1w ago

This study aimed to investigate the expression profile of immune response-related proteins of Behcet’s disease (BD) patients and identify potential biomarkers for this disease ..read more

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STING mediates experimental osteoarthritis and mechanical allodynia in mouse

BMC » Arthritis Research & Therapy

by Youngnim Shin, Deborah Cho, Seul Ki Kim and Jang-Soo Chun

1w ago

This study was performed to develop therapeutic targets of osteoarthritis (OA) that can be targeted to alleviate OA development (i.e., cartilage destruction) and relieve the OA-associated joint pain ..read more

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