Wiley Online Library » Arthritis & Rheumatology
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Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed publication for scientists and clinicians interested in the natural history, pathophysiology, treatment, and outcome of the rheumatic diseases. The journal publishes the highest quality basic and clinical research related to the rheumatic diseases, encompassing a wide range of areas of..
Wiley Online Library » Arthritis & Rheumatology
5d ago
Arthritis &Rheumatology, Accepted Article ..read more
Wiley Online Library » Arthritis & Rheumatology
5d ago
Arthritis &Rheumatology, Accepted Article ..read more
Wiley Online Library » Arthritis & Rheumatology
5d ago
Objective
Transcript and protein expression were interrogated to examine gene locus and pathway regulation in the peripheral blood of active adult dermatomyositis (DM) and juvenile DM (JDM) patients receiving immunosuppressive therapies.
Methods
Expression data from 14 DM and 12 JDM patients were compared to matched healthy controls. Regulatory effects at the transcript and protein level were analyzed by multi-enrichment analysis for assessment of affected pathways within DM and JDM.
Results
Expression of 1,124 gene loci were significantly altered at the transcript or protein levels across DM ..read more
Wiley Online Library » Arthritis & Rheumatology
5d ago
Objectives
Rheumatoid arthritis (RA) is characterized by erosive joint damage, deterioration of bone mass and biomechanics. Preclinical evidence suggests a beneficial effect of Janus Kinase inhibition (JAKi) on bone properties, but clinical data are scarce to date. In this study we evaluated the effect of JAKi through baricitinib (BARI) on (i) volumetric bone mineral density (vBMD), bone microstructure, biomechanics, erosion repair and (ii) synovial inflammation in RA patients.
Methods
Prospective, single-arm, interventional, open-label, single-center phase 4 study in RA patients with patholog ..read more
Wiley Online Library » Arthritis & Rheumatology
5d ago
The management of Sjogren's disease is challenging because of several factors. Indeed, the presentations are heterogeneous, and one must be able to identify prognostic markers to adapt the follow-up. In addition, there is no validated treatment. Nevertheless, international experts have been working for several years to establish recommendations to guide management. However, research in this field is extremely active, and we can hope for the development of effective treatments for our patients in the near future.
This article is protected by copyright. All rights reserved ..read more
Wiley Online Library » Arthritis & Rheumatology
5d ago
Objective
To develop initial American College of Rheumatology (ACR) guidelines on the use of exercise, rehabilitation, diet, and additional interventions in conjunction with disease-modifying antirheumatic drugs (DMARDs) as part of an integrative management approach for people with rheumatoid arthritis (RA).
Methods
An interprofessional guideline development group constructed clinically relevant Population, Intervention, Comparator, and Outcome (PICO) questions. A literature review team then completed a systematic literature review and applied the Grading of Recommendations Assessment, Develop ..read more
Wiley Online Library » Arthritis & Rheumatology
1w ago
Objective
We aimed to decipher the gut microbiome (GM) and serum metabolic characteristic of individuals at high risk for rheumatoid arthritis (RA) and to investigate the causative effect of GM on the mucosal immune system and its involvement in the pathogenesis of arthritis.
Design
Fecal samples were collected from 38 healthy individuals (HCs) and 53 high-risk RA individuals with anti-citrullinated protein antibody (ACPA)-positivity (PreRA), 12 of 53 PreRA developed RA within 5 years of follow-up. The differences in intestinal microbial composition between the HC and PreRA individuals or amon ..read more
Wiley Online Library » Arthritis & Rheumatology
1w ago
Objective
Previous studies underline the genetic susceptibility in the pathogenesis of Palindromic Rheumatism (PR), but the known PR loci only explain partially the disease's genetic background. We aim to genetically identify PR by whole exome sequencing (WES).
Methods
This multi-center prospective study was conducted in ten Chinese specialized rheumatology centers between September 2015 and January 2020. WES was performed in a PR cohort (185 PR cases and 272 healthy controls). PR patients were divided in to ACPA- PR and ACPA+ PR subgroups according to ACPA titer (cut-off value: 20UI/I). Whole ..read more
Wiley Online Library » Arthritis & Rheumatology
1w ago
Objective
The inflammatory arthritides (IA) make up a significant proportion of conditions followed-up in rheumatology clinics. These patients require regular monitoring, but this is increasingly difficult with rising patient numbers and demand on clinics. Our objective is to evaluate the clinical impact of electronic Patient Reported Outcome Measures (ePROMs) as a digital remote monitoring intervention on disease activity, treatment decisions and healthcare resource use in patients with IA.
Methods
Five databases (MEDLINE, Embase, PubMed, Cochrane Library and Web of Science) were searched, wi ..read more
Wiley Online Library » Arthritis & Rheumatology
2w ago
Objective
Brepocitinib is a tyrosine kinase 2/Janus kinase 1 inhibitor in development for treatment of several immunological diseases. Efficacy and safety of oral brepocitinib were assessed in participants with moderately-to-severely active psoriatic arthritis (PsA) for up to 52 weeks.
Methods
This placebo-controlled, dose-ranging, phase IIb study randomized participants to brepocitinib 10 mg once daily (QD), 30 mg QD, 60 mg QD, or placebo, advancing to brepocitinib 30 or 60 mg QD at week 16. The primary endpoint was American College of Rheumatology (ACR)20 response rate at week 16. Secondary ..read more