Good morning and welcome to another MicrobiomeDigest! Did you know that one group of scientists is using video games to crowdsource puzzle solutions to improve microbiome research? What a neat way to approach citizen science! On deck today we have a study about pesticide exposure and the gut microbiome, a review of the emerging field ..read more

Human and General Microbiome Human fecal alpha-glucosidase activity and its relationship with gut microbiota profiles and early stages of intestinal mucosa damage – Sergio Ruiz-Saavedra – Anaerobe The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut – Cassandra E Gheorghe – Cell Reports Alterations in gut microbiota contribute to cognitive deficits induced ..read more

Today’s digest features human gut microbiome studies on dietary fiber and fasting glucose, ocean microbiome, pangenome approaches, and more. See you at #MVIF! Oral microbiome Saliva sampling method influences oral microbiome composition and taxa distribution associated with oral diseases – Cristian Roca – PlosOne Gut microbiome Changes in the intestinal microbiota of individuals with non-alcoholic ..read more

Human and General Microbiome The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation – Eun-Jung Kang – Nature Communications A universal plasma metabolites-derived signature predicts cardiovascular disease risk in MAFLD – Zhonglin Li – Atherosclerosis Oral-gut microbial transmission promotes diabetic coronary heart disease – Yiwen Li – Cardiovascular Diabetology ..read more

Human Microbiome The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children – Sarah M Heston – Gut Microbes Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung – Patrick J Dörner – Nature Communications The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and ..read more

Human Microbiome A host-microbiota interactome reveals extensive transkingdom connectivity – Nicole D Sonnert – Nature A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche – Martha Zepeda-Rivera – Nature Cluster-specific associations between the gut microbiota and behavioral outcomes in preschool-aged children – Marcel van de Wouw – Microbiome Association between oral and fecal microbiome ..read more

Human gut and general microbiome Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition – Hao-Wei Chang et al – Nature Microbiology Outcomes after Fecal Microbiota Transplantation in combination with Bezlotoxumab for Inflammatory Bowel Disease and Recurrent C. difficile Infection – Jessica R Allegretti – American Journal of Gastroenterology ..read more

Human Microbiome Stratification of Fusobacterium nucleatum by local health status in the oral cavity defines its subspecies disease association – Madeline Krieger – Cell Host & Microbe Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions – Jingjing Cong – Immunity Longitudinal profiling of the microbiome at ..read more

Human gut microbiome Gut microbiota–tryptophan metabolism–GLP-1 axis participates in β-cell regeneration induced by dapagliflozin – Yafei Jiang et al – Diabetes Inhibition of inosine metabolism of the gut microbiota decreases testosterone secretion in the testis – Lei Tang et al – mSystems [REVIEW] Exploring the gut microbiota and its potential as a biomarker in gliomas ..read more

Human and General Microbiome A cryptic plasmid is among the most numerous genetic elements in the human gut – Emily C. Fogarty – Cell Associations between bacterial and fungal communities in the human gut microbiota and their implications for nutritional status and body weight – Ricardo García-Gamboa – Scientific Reports Multicomponent (bio)markers for obesity risk ..read more