A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
Nature » Stem cells
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5d ago
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface ..read more
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Rebalancing the aged immune system
Nature » Stem cells
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5d ago
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface ..read more
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Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research
Nature » Stem cells
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5d ago
Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research ..read more
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Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways
Nature » Stem cells
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5d ago
Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways Precise genome editing is crucial. Here the authors demonstrate that dual inhibition of p53-mediated cell death and distinct activation of the DNA damage repair system upon DNA damage by cytosine base editor (CBE) or prime editor (PE) additively enhanced editing efficiency in hPSCs ..read more
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Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases
Nature » Stem cells
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5d ago
Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases Integrating human pluripotent stem cell models with population genetics and cellular genomics can help elucidate functional mechanisms underlying complex disease risk loci and uncover relationships between common genetic variation and pharmacotherapeutic phenotypes ..read more
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Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease
Nature » Stem cells
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5d ago
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease ..read more
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Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth
Nature » Stem cells
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5d ago
Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth Human hepatocytes remain hard to grow in vitro. Here, the authors temporally map the early stages of organoid growth initiated from fetal and adult hepatocytes, leveraging this knowledge to design maturation and improved expansion conditions ..read more
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Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue
Nature » Stem cells
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2w ago
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Connie J. Eaves (1944–2024)
Nature » Stem cells
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2w ago
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Airway hillocks are injury-resistant reservoirs of unique plastic stem cells
Nature » Stem cells
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2w ago
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