‘Mini liver’ will grow in person’s own lymph node in bold new trial Biotechnology firm LyGenesis has injected donor cells into a person with liver failure for the first time ..read more

Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage Molecular changes in neurodegeneration occur much earlier than previously expected. In this study, dynamic molecular network analysis of iPSC differentiation uncovers a temporal pathway from histone to ISG15 with the earliest molecular changes of SCA1 ..read more

Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity ..read more

Umbilical cord mesenchymal stem cell-derived exosomes inhibits fibrosis in human endometrial stromal cells via miR-140-3p/FOXP1/Smad axis ..read more

DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells Inflammatory bowel disease (IBD) is featured with epithelial barrier dysfunction, however, the underlying mechanism is less clear. Here, the authors show that DHX9 deficiency in intestinal stem cells (ISCs) induces accumulation of abnormal R-loops and subsequent genomic instability, leading to impairment of ISCs and development of IBD ..read more

Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis Elucidating the gastroesophageal junction’s development is key to comprehending its disease susceptibility. Here, the authors mapped its development, uncovering cellular diversity and interaction dynamics using advanced spatiotemporal single-cell analysis ..read more

CD32 captures committed haemogenic endothelial cells during human embryonic development Scarfò, Randolph et al. perform transcriptomic analysis of 28- to 32-day human embryos and identify CD32 as a marker of haemogenic endothelial cells (HECs), thus providing a strategy to isolate HECs from human embryos and pluripotent stem cell cultures ..read more

Threonine fuels brain tumor growth through a conserved tRNA modification A CRISPR dropout screen for tRNA regulators identified as the top essential gene in glioblastoma stem cells. Threonine acts as a substrate of YRDC to facilitate the A) tRNA modification and shift translation toward mitosis-related genes with a codon bias. Our findings support targeting glioblastoma growth by a well-tolerated dietary therapy ..read more

A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex Coquand, Brunet Avalos et al. develop an imaging method to map basal radial glial cell division in human fetal tissue and cerebral organoids and detect abundant symmetric amplifying, but also direct neurogenic divisions bypassing intermediate progenitors ..read more

Improving the EASIX’ predictive power for NRM in adults undergoing allogeneic hematopoietic cell transplantation ..read more