LIF maintains mouse embryonic stem cells pluripotency by modulating TET1 and JMJD2 activity in a JAK2‐dependent manner
Wiley Online Library » Stem Cells
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1y ago
JAK2 is the key mediator of LIF-mediated epigenetic control in mouse embryonic stem cells pluripotency and maintenance. JAK2 activation by LIF induces its translocation to the nucleus. Activated JAK2 directly interacts with core epigenetic enzymes TET1 and JMJD2, modulating its activity and promotes the DNA and histone demethylation, respectively. JAK2 also induces DNA methyltransferases phosphorylation and primes it for degradation. All together, these JAK2-mediated effects establish an open epigenetic status in the pluripotency genes promoter regions ..read more
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Suppressing Hippo signaling in the stem cell niche promotes skeletal muscle regeneration
Wiley Online Library » Stem Cells
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1y ago
Our AAV9 Salvador shRNA strategy recreates a myofiber-guided regenerative stem cell niche and promotes simultaneous myogenesis and angiogenesis-neovascularization for the functional recovery of skeletal muscles in ischemic extremities. These myofibers release paracrine elements to activate (a) satellite cells to proliferate and self-renew for myogenesis and (b) endothelial cells to stimulate angiogenesis and neovascularization ..read more
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Protein kinase C‐β‐dependent changes in the glucose metabolism of bone marrow stromal cells of chronic lymphocytic leukemia
Wiley Online Library » Stem Cells
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1y ago
Protein kinase-C-β-dependent changes in the metabolism of bone marrow stromal cells after contact to malignant B-cells ..read more
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Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views
Wiley Online Library » Stem Cells
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1y ago
Reprogramming of normal fibroblasts to induced pluripotent stem cells is characterized by low efficiency due to the upregulation of tumour suppressors and reprogramming induced senescence (RIS). Spy1 can be combined with classical pluripotency factors to override RIS through activation of EZH2 followed by an increase in trimethylation of histone H3 at the lysine 27 residue ..read more
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Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
Wiley Online Library » Stem Cells
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1y ago
Reprogramming of normal fibroblasts to induced pluripotent stem cells is characterized by low efficiency due to the upregulation of tumour suppressors and reprogramming induced senescence (RIS). Spy1 can be combined with classical pluripotency factors to override RIS through activation of EZH2 followed by an increase in trimethylation of histone H3 at the lysine 27 residue ..read more
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The Cyclin‐Like Protein SPY1 overrides Reprogramming Induced Senescence Through EZH2 Mediated H3K27me3
Wiley Online Library » Stem Cells
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1y ago
Reprogramming of normal fibroblasts to induced pluripotent stem cells is characterized by low efficiency due to the upregulation of tumour suppressors and reprogramming induced senescence (RIS). Spy1 can be combined with classical pluripotency factors to override RIS through activation of EZH2 followed by an increase in trimethylation of histone H3 at the lysine 27 residue ..read more
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Bidirectional relationship between cardiac extracellular matrix and cardiac cells in ischemic heart disease
Wiley Online Library » Stem Cells
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1y ago
Our review focuses on the cardiac extracellular matrix (ECM) and cardiac fibroblasts (CFs), cardiac-derived progenitor cells (CPCs), and mesenchymal stem cells (MSCs), and their constant interplay in response to tissue development, aging, disease progression, and repair ..read more
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The Cyclin‐Like Protein SPY1 overrides Reprogramming Induced Senescence Through EZH2 Mediated H3K27me3
Wiley Online Library » Stem Cells
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1y ago
..read more
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Bidirectional relationship between cardiac extracellular matrix and cardiac cells in ischemic heart disease
Wiley Online Library » Stem Cells
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1y ago
..read more
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Human multipotent adult progenitor cells effectively reduce graft‐vs‐host disease while preserving graft‐vs‐leukemia activity following experimental, allogeneic bone marrow transplantation
Wiley Online Library » Stem Cells
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1y ago
Bio-redistribution of MAPC cells from the lung and to the liver and spleen of allogeneic BMT recipient mice as captured by 3-D, computer-generated imagery ..read more
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