JAK2 is the key mediator of LIF-mediated epigenetic control in mouse embryonic stem cells pluripotency and maintenance. JAK2 activation by LIF induces its translocation to the nucleus. Activated JAK2 directly interacts with core epigenetic enzymes TET1 and JMJD2, modulating its activity and promotes the DNA and histone demethylation, respectively. JAK2 also induces DNA methyltransferases phosphorylation and primes it for degradation. All together, these JAK2-mediated effects establish an open epigenetic status in the pluripotency genes promoter regions ..read more

Our AAV9 Salvador shRNA strategy recreates a myofiber-guided regenerative stem cell niche and promotes simultaneous myogenesis and angiogenesis-neovascularization for the functional recovery of skeletal muscles in ischemic extremities. These myofibers release paracrine elements to activate (a) satellite cells to proliferate and self-renew for myogenesis and (b) endothelial cells to stimulate angiogenesis and neovascularization ..read more

Protein kinase-C-β-dependent changes in the metabolism of bone marrow stromal cells after contact to malignant B-cells ..read more

Reprogramming of normal fibroblasts to induced pluripotent stem cells is characterized by low efficiency due to the upregulation of tumour suppressors and reprogramming induced senescence (RIS). Spy1 can be combined with classical pluripotency factors to override RIS through activation of EZH2 followed by an increase in trimethylation of histone H3 at the lysine 27 residue ..read more

Reprogramming of normal fibroblasts to induced pluripotent stem cells is characterized by low efficiency due to the upregulation of tumour suppressors and reprogramming induced senescence (RIS). Spy1 can be combined with classical pluripotency factors to override RIS through activation of EZH2 followed by an increase in trimethylation of histone H3 at the lysine 27 residue ..read more

Reprogramming of normal fibroblasts to induced pluripotent stem cells is characterized by low efficiency due to the upregulation of tumour suppressors and reprogramming induced senescence (RIS). Spy1 can be combined with classical pluripotency factors to override RIS through activation of EZH2 followed by an increase in trimethylation of histone H3 at the lysine 27 residue ..read more

Our review focuses on the cardiac extracellular matrix (ECM) and cardiac fibroblasts (CFs), cardiac-derived progenitor cells (CPCs), and mesenchymal stem cells (MSCs), and their constant interplay in response to tissue development, aging, disease progression, and repair ..read more

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Bio-redistribution of MAPC cells from the lung and to the liver and spleen of allogeneic BMT recipient mice as captured by 3-D, computer-generated imagery ..read more