Issue Information
Wiley Online Library » International Journal of Experimental Pathology
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1M ago
International Journal of Experimental Pathology, Volume 105, Issue 3, Page 87-89, June 2024 ..read more
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Correction to “Clinical applications of gene therapy for rare diseases: A review”
Wiley Online Library » International Journal of Experimental Pathology
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2M ago
International Journal of Experimental Pathology, EarlyView ..read more
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Muscle fibre morphometric analysis (MusMA) correlates with muscle function and cardiovascular risk prognosis
Wiley Online Library » International Journal of Experimental Pathology
by Larisse Longo, Bárbara Jonson Bartikoski, Valessa Emanoele Gabriel de Souza, Fernando Salvati, Carolina Uribe‐Cruz, Guido Lenz, Ricardo Machado Xavier, Mário Reis Álvares‐da‐Silva, Eduardo Cremonese Filippi‐Chiela
2M ago
Abstract Morphometry of striated muscle fibres is critical for monitoring muscle health and function. Here, we evaluated functional parameters of skeletal and cardiac striated muscle in two experimental models using the Morphometric Analysis of Muscle Fibre tool (MusMA). The collagen-induced arthritis model was used to evaluate the function of skeletal striated muscle and the non-alcoholic fatty liver disease model was used for cardiac striated muscle analysis. After euthanasia, we used haeamatoxylin and eosin stained sections of skeletal and cardiac muscle to perform muscle fibre segmentation ..read more
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Microfluidics‐based EGFR mutation detection and its implication in the resource‐limited clinical setting
Wiley Online Library » International Journal of Experimental Pathology
by Pradnya Joshi, Prachi Gogte, Trupti Pai, Mamta Gurav, Dipika Dhanawade, Nupur Karnik, Gauri Deshpande, Rajiv Kaushal, Omshree Shetty
2M ago
Abstract Management of lung cancer today obligates a mutational analysis of the epidermal growth factor receptor (EGFR) gene particularly when Tyrosine Kinase Inhibitor (TKI) therapy is being considered as part of prognostic stratification. This study evaluates the performance of automated microfluidics-based EGFR mutation detection and its significance in clinical diagnostic settings. Formalin-fixed, paraffin-embedded (FFPE) samples from NSCLC patients (n = 174) were included in a two-phase study. Phase I: Validation of the platform by comparing the results with conventional real-time PCR and ..read more
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Trilobatin contributes to the improvement of myopathy in a mouse model of Duchenne muscular dystrophy
Wiley Online Library » International Journal of Experimental Pathology
by Túlio de Almeida Hermes, Paula Fratini, Beatriz Godinho Nascimento, Laís Leite Ferreira, Giuliana Petri, Fernando Luiz Affonso Fonseca, Alzira Alves de Siqueira Carvalho, David Feder
4M ago
Abstract Duchenne muscular dystrophy (DMD) occurs due to genetic mutations that lead to a deficiency in dystrophin production and consequent progressive degeneration of skeletal muscle fibres, through oxidative stress and an exacerbated inflammatory process. The flavonoid trilobatin (TLB) demonstrates antioxidant and anti-inflammatory potential. Its high safety profile and effective action make it a potent therapy for the process of dystrophic muscle myonecrosis. Thus, we sought to investigate the action of TLB on damage in a DMD model, the mdx mouse. Eight-week-old male animals were treated w ..read more
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TGFβR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll‐like‐receptor signalling
Wiley Online Library » International Journal of Experimental Pathology
by Fatma El Zahraa Ammar Mohamed, Bedair Dewidar, Tao Lin, Matthias P. Ebert, Steven Dooley, Nadja M. Meindl‐Beinker, Seddik Hammad
5M ago
Abstract Transforming growth factor (TGF)-β and toll-like receptors (TLRs) have been shown to independently modulate the proliferation of hepatocellular carcinoma (HCC). Since a direct cross-talk between these two signalling pathways in HCC has not been clearly described before, we aimed here to explore the possibility of such interaction. A human HCC tissue array (n = 20 vs. four control samples), human HCC samples (n = 10) and steatohepatitis-driven murine HCC samples (control, NASH and HCC; n = 6/group) were immunostained for TGFβR1, pSMAD2, TRAF6, IRAK1 and PCNA. The results were confirmed ..read more
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Issue Information
Wiley Online Library » International Journal of Experimental Pathology
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6M ago
International Journal of Experimental Pathology, Volume 105, Issue 1, Page 1-3, February 2024 ..read more
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MiR‐22‐3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1‐PI3K/AKT pathway
Wiley Online Library » International Journal of Experimental Pathology
by Chunqiu Wang, Xinguo Wang, Hui Cheng, Jiahu Fang
7M ago
Abstract Bone fractures are the most common form of musculoskeletal trauma worldwide. Numerous microRNAs (miRNAs) have been suggested to be participants in regulating bone-related diseases. Recent studies revealed the regulatory role of miR-22-3p in osteogenic differentiation, but its role in fracture healing has not been investigated previously. Here, a rat femoral fracture model was established, Bone marrow mesenchymal stem cells (BMSCs) were isolated to detect the specific function and underlying mechanisms of miR-22-3p. MiR-22-3p and sclerostin domain-containing 1 (SOSTDC1) expression was ..read more
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Increased accumulation of the advanced glycation endproduct Ne(carboxymethyl) lysine in the intramyocardial vasculature in patients with epicarditis
Wiley Online Library » International Journal of Experimental Pathology
by U Baylan, A Baidoshvili, S Simsek, CG Schalkwijk, HWM Niessen, PAJ Krijnen
7M ago
Abstract Advanced glycation end-products (AGEs) are implicated in the pathogenesis of vascular disease. In previous studies we have found increased deposition of N(e)-(carboxymethyl)lysine (CML) in intramyocardial vasculature in the heart in acute myocardial infarction and myocarditis. It is known that the process of inflammation plays a role in the formation of AGEs. In this study we have explored the presence of CML (a major AGE) in the heart of patients with epicarditis using a monoclonal anti-CML antibody. Nine patients with epicarditis (n = 9) died and their hearts were used for this stud ..read more
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Circular RNA circVAPA modulates macrophage pyroptosis in sepsis‐induced acute lung injury through targeting miR‐212‐3p/Sirt1/Nrf2/NLRP3 axis
Wiley Online Library » International Journal of Experimental Pathology
by Yanjing Huang, Jinquan Lin, Zhiwei Wu, Yiming Li
7M ago
Abstract Sepsis-induced acute lung injury (ALI) is an inflammatory condition involving the pyroptosis of macrophages. This study investigated the role of circular RNA hsa_circ_0006990 (circVAPA) in regulating macrophage pyroptosis in ALI and the underlying mechanisms. The expression pattern of circVAPA was examined in the mouse model of ALI and in the LPS-treated RAW264.7 macrophage cell line. Lung tissue damage was evaluated by haematoxylin and eosin staining, immunohistochemistry and a myeloperoxidase activity assay. The molecular mechanisms were investigated by luciferase reporter assay, we ..read more
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