Wiley Online Library » Journal of Paediatrics and Child Health
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The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.
Wiley Online Library » Journal of Paediatrics and Child Health
3d ago
Aim
Many countries have detailed recommendations for haemophilia patients to reduce the risk of vaccination-related bleeding. However, data from developing countries are lacking. We investigated scheduled vaccinations and vaccination-related bleeding complications in Chinese children with haemophilia and analysed issues related to vaccinations.
Methods
Children with haemophilia in the PUMCH Haemophilia Treatment Centre were contacted via telephone. We distributed a vaccination questionnaire to their parents. The severity of haemophilia, coagulation factor infusions before vaccination, injectio ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
3d ago
Journal of Paediatrics and Child Health, EarlyView ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
3d ago
Aim
Delays in care may be a driver of inequities in perforated appendicitis rates. The goal of this study was to explore potential causes of delay in care for children with perforated appendicitis.
Methods
We conducted an interview study of caregivers of children admitted with perforated appendicitis to a children's hospital between December 2022 and March 2023. Semi-structured interviews based on an iteratively revised interview guide were conducted in-person during the child's admission. All interviews were transcribed, coded and underwent a process of thematic analysis.
Results
We reached t ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
3d ago
Aim
To assess the impact of the Early Onset Sepsis (EOS) calculator, implemented as a quality improvement study, to reduce the rate of unnecessary antibiotics in neonates born ≥35 weeks' gestation.
Methods
An audit of routinely collected hospital data from January 2008 to March 2014 (retrospective) and from January 2018 to September 2019 (prospective) determined baseline incidence of EOS intravenous antibiotic use in neonates born ≥35 weeks' gestation in a tertiary level perinatal centre. Plan-do-study-act (PDSA) cycles were applied to implement the EOS calculator. Statistical process control ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
3d ago
Background
Typhoid is endemic in many low-income countries, including in Papua New Guinea. This study aimed to describe the burden and clinical features of typhoid in children in a provincial hospital, to describe environmental conditions that lead to typhoid, and to document the antibiotic sensitivity of Salmonella spp. in the Eastern Highlands Province.
Methods
A combined retrospective and prospective study of children admitted to with clinical features of typhoid to the Goroka Hospital throughout 2022.
Results
The study included 98 children, of which 54% were female. The median age was 8 (I ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
3d ago
Background
Atypical haemolytic uraemic syndrome (aHUS) is a rare thrombotic microangiopathy resulting from dysregulation of the alternative complement pathway, leading to multi-organ dysfunction and chronic kidney disease. Eculizumab is an anti-C5 monoclonal antibody therapy that has significantly improved aHUS disease control and patient outcomes, however it requires fortnightly intravenous dosing. This often necessitates long term central access and a high hospital attendance burden. Ravulizumab is a novel, next-generation anti-C5 monoclonal antibody engineered from eculizumab to reduce endo ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
1w ago
Aim
To describe the characteristics of patients with chronic hepatitis B (CHB) presenting to a tertiary paediatric hospital in Perth, Western Australia. Review of implementation of previous follow-up recommendations for the cohort was also undertaken.
Method
A retrospective data analysis of all individuals aged between 0 and 17 years presenting to the tertiary children's hospital who were hepatitis B surface antigen (HBsAg) positive over 8 years (2013–2020). Demographic features, clinical progress and follow up are described, including proportion transferred to adult services.
Results
Seventy ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
1w ago
Aim
To describe the disease spectrum of torticollis in Chinese children and to improve its diagnostic flowchart.
Methods
A retrospective analysis was conducted at the Rehabilitation Department of Beijing Children’s Hospital from 2017 to 2021. Patients were diagnosed and referred based on a diagnostic flowchart of torticollis. Detailed patient data were collected from the outpatient electronic medical record system.
Results
A total of 2047 patients met the inclusion criteria. The top five conditions were congenital muscular torticollis (CMT) (76.6%), cerebral palsy (5.1%), ocular torticollis (4 ..read more
Wiley Online Library » Journal of Paediatrics and Child Health
1w ago
Aims
The New Zealand National Intestinal Failure and Rehabilitation Service (NZ-NIFRS) was established in October 2015 to gather longitudinal data on the aetiology, clinical course and outcomes of children with intestinal failure (IF). One main objective is to achieve health equity for patients with IF in NZ.
Methods
Clinical outcomes (enteral autonomy, parenteral nutrition (PN) dependence, death or intestinal transplantation) for IF patients diagnosed from October 2015 to 2018 were analysed; comparisons were made by ethnicity and socio-economic status (SES) using published ‘prioritised-ethnic ..read more
Genomic multidisciplinary teams: A model for navigating genetic mainstreaming and precision medicine
Wiley Online Library » Journal of Paediatrics and Child Health
3w ago
Aim
Recent rapid advances in genomics are revolutionising patient diagnosis and management of genetic conditions. However, this has led to many challenges in service provision, education and upskilling requirements for non-genetics health-care professionals and remuneration for genomic testing. In Australia, Medicare funding with a Paediatric genomic testing item for patients with intellectual disability or syndromic features has attempted to address this latter issue. The Sydney Children's Hospitals Network – Westmead (SCHN-W) Clinical Genetics Department established Paediatric and Neurology ..read more