Improving treatment of inflammatory breast cancer
TheoryLab
by American Cancer Society
2y ago
Inflammatory breast cancer (IBC) is rare and accounts for only 1% to 5% of all breast cancers, but it is considered an aggressive cancer because it grows quickly and is more likely to come back after treatment than other types of breast cancer. It causes symptoms of breast inflammation like swelling and redness, which is caused by cancer cells blocking lymph vessels in the skin causing the breast to look "inflamed." Gayathri R. Devi, PhD, is a two-time American Cancer Society grantee who recently received a Mission Boost Grant to “boost” her inflammatory breast cancer research and move it clos ..read more
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Cancer-related cognitive impairment
TheoryLab
by American Cancer Society
2y ago
People going through cancer treatment sometimes have cognitive changes such as trouble remembering, paying attention, or thinking clearly. Drs. Judith Carroll and Kathleen Van Dyk are clinician scientists who help patients with cancer-related cognitive impairment and conduct research into what causes it, how to identify patients at risk for it, and how to reverse its effects. Judith Carroll, PhD, is Associate Professor in the Department of Psychiatry and Biobehavioral Science at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, and she’s the term Endowed Chair of ..read more
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Targeted therapies, drug resistance, and two recent cancer research publications
TheoryLab
by American Cancer Society
2y ago
In this episode of the TheoryLab podcast, two American Cancer Society grantees discussed key takeaways from their recent publications. In the first part of the conversation, which is intended for a lay audience, Dr. Joshua Andersen and Dr. Bhuminder Singh talked about targeted therapies, treatment side effects, and drug resistance. Then they moved into a more technical discussion of their recent papers. Dr. Andersen recently published findings showing that “TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.” https://doi.org/10.1038/s41467-021-25 ..read more
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“Holding Hope for Cancer Patients with Serious Illness”
TheoryLab
by American Cancer Society
2y ago
When a cancer patient has a serious diagnosis, clinicians and families can struggle with how patients experience hope. Three distinguished palliative care physicians and researchers joined the podcast for a conversation about their recent paper in JAMA titled, “Holding Hope for Patients with Serious Illness” (https://jamanetwork.com/journals/jama/article-abstract/2784454). Drs. Abby Rosenberg, Robert Arnold, and Yael Schenker shared their own experiences treating seriously ill patients and talked about how we can navigate the tension between appreciating the potential therapeutic benefit of ho ..read more
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What causes small cell lung cancer growth and resistance?
TheoryLab
by American Cancer Society
2y ago
Lung cancer is the leading cause of cancer death among both men and women in the United States and worldwide. Small cell lung cancer comprises 15-17% of lung cancer cases, and it is the most aggressive subtype of lung cancer, growing rapidly and spreading to other organs quickly. Luke Hoeppner, PhD, received American Cancer Society funding to test whether therapeutically targeting a specific molecular pathway inhibits small cell lung cancer growth. Dr. Hoeppner’s lab was the first to report that activation of this particular pathway, called dopamine signaling, inhibits other forms of lung canc ..read more
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Improving our understanding of risk factors for breast cancer sub-types
TheoryLab
by American Cancer Society
2y ago
According to American Cancer Society researchers, in the United States in 2021, there will be an estimated 281,550 new cases of invasive breast cancer diagnosed in women.* Finding breast cancer early and getting state-of-the-art cancer treatment are the most important strategies to prevent deaths from breast cancer. Breast cancer that’s found early, when it’s small and has not spread, is easier to treat successfully. Getting regular screening tests is the most reliable way to find breast cancer early. The American Cancer Society has screening guidelines for women at average risk of breast canc ..read more
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Fixing prescription drug coverage and reducing the financial burden of cancer
TheoryLab
by American Cancer Society
2y ago
“More than 50% of cancer survivors report problems paying medical bills, financial distress, or delaying and/or forgoing medical care in the past year.”* The financial burden of cancer can affect survivors for years. And it can affect anyone: a cancer diagnosis as a young adult can have financial ramifications that can change the course of a person’s life; a diagnosis for someone who’s retired and on a fixed income can pose problems that nobody should have to face. The cost of cancer treatment also deepens disparities—not everyone can afford the most effective treatments. Stacie Dusetzina, PhD ..read more
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Maximizing what's learned from clinical trials in children
TheoryLab
by American Cancer Society
3y ago
The St. Baldrick's Foundation, the largest charitable funder of childhood cancer research grants, and the American Cancer Society, a health organization dedicated to eliminating cancer, formed a partnership in 2019 to fund grants that will accelerate childhood cancer research with the goals of understanding and discovering new treatment options and improving care and survival in children with cancer. Kathleen Ruddy, St. Baldrick’s Foundation CEO, joined the podcast to talk through the goals of this unique partnership. “Why do some patients respond better than others to a particular treatment ..read more
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“Overstretched & Overlooked: Solving challenges faced by early-career scientists after the pandemic”
TheoryLab
by American Cancer Society
3y ago
A new publication by six current and former American Cancer Society grantees describes the challenges faced by early-career investigators as a result of the pandemic and offers recommendations “to help institutions and individuals develop effective strategies to promote success and career advancement.” They joined the TheoryLab podcast to talk about key takeaways from their article, which “highlights the aftermath of the pandemic on work–life balance, promotion, tenure, funding, networking, and mentoring, and make recommendations that can help remediate these problems.” “Overstretched and over ..read more
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Catching the problem early: The early stages of lung cancer initiation & melanoma drug resistance
TheoryLab
by American Cancer Society
3y ago
Two American Cancer Society grantees—one with a recent publication on the early mechanisms of lung cancer initiation, the other with a new study out on the development of melanoma resistance during the earliest phases of treatment—joined the podcast for a conversation about catching the problem early. This conversation is geared for a scientific audience, until the last few minutes. Sabrina Spencer, PhD, is Associate Professor of Biochemistry at University of Colorado, Boulder. She recently published a study in Nature Communications on “Melanoma subpopulations that rapidly escape MAPK pathway ..read more
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