High Prevalence of Advanced HIV Disease at Diagnosis in a Multi-Center Study: Urgent Need for Early Intervention
American Journal of Infectious Diseases and Microbiology
by Berhanu M. Abera, Zekarias S. Ayalew, Abel T. Tasamma, Amir Muhdin, Eyob Beyene, Anteneh Eshetu, Eskedar F. Azerefegne, Tilahun Bizuayehu, Yared Getachew, Biruk Abate, Asrat Berihun, Sibehatleab T. Mulate, Abel Andargie, Surafel Adugna, Mehariw W. Netsere, Kemer Kedir, Zelalem B. Ayele, Abraham Workneh, Bereket Abraha Molla, Wondwossen A. Degu
4d ago
Introduction: Many patients having HIV present to the health care system with advanced HIV disease. Patients with advanced HIV disease have CD4 cell count of less than 200cells/mm3 or WHO stage III or IV clinical events. The primary culprits responsible for severe morbidity and mortality are tuberculosis, severe bacterial infections and cryptococcal meningitis. Methods: A retrospective multi-centered facility based cross-sectional study was conducted among newly diagnosed HIV patients whose age was ≥ 15 years over a period of one year (October 2023-January 2024). The prevalence of advanced HIV ..read more
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Left Ventricular Systolic Dysfunction in the Antiretroviral Therapy Era: A Call for Comprehensive Cardiovascular Management in People Living with HIV in Ethiopia
American Journal of Infectious Diseases and Microbiology
by Abinet Tekalign Manyahilal, Dufera mekonnen, Amanuel Gebreselassie Tesfaye, Zekarias Seifu Ayalew, Gebeyehu Tessema Azibte, Biruk Abate legesse, Samuel Tsehaye Gebremedhin
4d ago
Background: Access to antiretroviral therapy (ART) has transformed HIV infection into a chronic disease. However, cardiovascular disease (CVD) is now a leading cause of morbidity and mortality among people living with HIV (PLWH). This study assessed the prevalence and predictors of left ventricular systolic dysfunction (LVSD) among PLWH in Ethiopia. Methods: An institution-based cross-sectional study involving 156 PLWH was conducted. Medical records were reviewed, and a structured questionnaire was used to collect data on demographics, clinical characteristics, medications, and echocardiograph ..read more
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Determination of Antibacterial Activity of 5-Bromosalicylidene-Aniline, 5-Bromosalicylidene-4-Nitroaniline and Their Cobalt (II) Complexes
American Journal of Infectious Diseases and Microbiology
by Karithi J. Muketha, Gichumbi M. Joel, Michura J.G. Anne, Ombaka Ochiengi
1M ago
Antibacterial resistance is a serious global health problem in human beings. Emergence and increase in number of drug resistant and multidrug resistant microorganisms is at an alarming rate. Thus, there is a pressing need for the development of novel antibacterial drugs with promising activity, which can potentially address this resistance. Schiff bases with 5-bromosalicylidene-aniline (BA), 5-bromosalicylidene-4-nitroaniline (BN) and their cobalt (II) complexes had been synthesized but there antibacterial activity has not been done. In this work, the antibacterial activity of 5-bromosalicylid ..read more
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Hantavirus Disease: An Emerging and Re-Emerging Viral Disease of Public Health Concern
American Journal of Infectious Diseases and Microbiology
by Mahendra Pal, Kirubel Paulos Gutama
3M ago
Emergence and re-emergence of viral zoonoses pose a serious threat to human and animal health. Hantaviruses are enveloped negative (-) single-stranded RNA viruses that belong to Hantaviridae family, which are transmitted to humans through inhalation and are harbored by small rodents. Humans can develop two clinical syndromes as a result of hantavirus infection: haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which are caused by Old World and New World hantaviruses, respectively. Infections with the hantavirus are rather common in peoples in parts o ..read more
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Tetanus News in the Infectious Diseases Department of Brazzaville University Hospital from 2018 to 2023
American Journal of Infectious Diseases and Microbiology
by Ossibi Ibara BR, Ngakengni NY, Adoua Doukaga T, Ollandzobo Atipo Ibara LC, Ekat M, Mpassy, Angonga Pabota E, Bendett Lebaho P, Okoko AR, Mbika CA
4M ago
Introduction: Tetanus is a real public health problem in the tropics and in the Congo, with high morbidity and mortality despite the existence of an effective, well-tolerated vaccine. Objective: to contribute to the improvement of tetanus management at Brazzaville University Hospital. Patients and method: cross-sectional, descriptive study of tetanus cases admitted to the infectious diseases department between January 1, 2018 and August 31, 2023, i.e. 5 years and 8 months. Patients aged at least 1 year and meeting the selection criteria were included. Results: Out of 561 admissions, there were ..read more
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Human Papilloma Virus: A Comprehensive Review
American Journal of Infectious Diseases and Microbiology
by Shreya Veggalam, Venkataramana Kandi, Srikar Reddy Vummenthala
4M ago
Human Papillomavirus (HPV) is among several Deoxyribonucleic acid (DNA) viruses that can infect humans. HPV is a tumorigenic virus associated with carcinoma of the cervix in females. Additionally, HPV was found to be involved in the development of oropharyngeal and anogenital cancers. Cervical cancer is the second most predominant cancer resulting in death among women worldwide. Despite the availability of an approved vaccine, there is little awareness about the vaccine that could be administered to prevent HPV-associated cancers. HPV has been causing trouble in the lives of millions of women ..read more
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Investigation of Klebsiella pneumonia and Acinetobacter baumannii Outbreak at a Secondary Care Hospital in Saudi Arabia
American Journal of Infectious Diseases and Microbiology
by Semaa M al radhwan, Eman barnawi, Atef M. shibl, Omar Alharbi, Majed Al mograbi, Ateeq al garni, Nasser Al-shanbari
5M ago
Background: Carbapenem-resistant Acinetobacter baumannii (A. baumannii) and Klebsiella pneumonia (K. pneumonia) are accused of high prevalence and ability to cause outbreaks in healthcare settings. The current work aimed to analyze one of the major K. pneumonia and A. baumannii outbreaks at a secondary care hospital in Riyadh, Saudi Arabia including the identification of patients’ infectivity and mortality risk factors, antibiotic susceptibility test results of the bacterial isolates, and infection control measures employed to halt the outbreak. Methods: A cross-sectional study was conducted f ..read more
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The Online Courses at OpenWHO Platform Integrated into the Medical Undergraduate Curriculum to Teach Microbiology: A Microbiologist’s Perspective
American Journal of Infectious Diseases and Microbiology
by Venkataramana Kandi
7M ago
The Coronavirus Disease 2019 (COVID-19) caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has severely affected people throughout the world. The initial months of the pandemic were horrifying due to the increased spread of infections and the resultant morbidity and mortality. Healthcare workers (HCWs) and hospital establishments were overwhelmed by high rates of infections and hospital admissions. Additionally, the general population, mostly belonging to developing and poor countries, had minimal knowledge of infectious diseases and their dynamics including disea ..read more
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Antimicrobial Susceptibility Patterns of Germs Isolated from Sterile Body Fluids in Yaounde, Cameroon
American Journal of Infectious Diseases and Microbiology
by Laure Ngando, Leopold Mbous Nguimbus, Alice Ghislaine Ndoumba Afouba, Thérèse Nkoa1, Albert Legrand Same Ekobo
7M ago
Background: Infections of sterile body fluids are a global health problem, resulting in the deaths of an estimated 600,000 to 800,000 adults each year, according to World Health Organization estimates. The aim of this research was to present the microbiological, susceptibility and antimicrobial resistance profile of germs isolated from sterile body fluids during the study period. Methods: The study took place in the central region at the Centre Pasteur of Cameroon (CPC) from January 2010 to December 2019. Sterile body fluids (joint fluid, ascitic fluid, drain fluid, gastric fluid, hepatic flui ..read more
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Antimicrobial Susceptibility Patterns of Gram-negative Bacteria, Gram-positive Bacteria and Fungi Species Isolated from Blood Culture Bottles in Yaounde, Cameroon
American Journal of Infectious Diseases and Microbiology
by Laure Ngando, Leopold Mbous Nguimbus, Massongo Massongo, Marie Chantal Ngonde Essome, Albert Legrand Same Ekobo
8M ago
Background: Bloodstream infections (BSIs) are the leading cause of mortality and morbidity worldwide. The aim of this study was to determine the prevalence of germs isolated from blood culture bottles, to see if age and sex are a risk factor for infection, and to present sensitivity and resistance profiles of the germs most represented during the study period. Methods: This was a retrospective and observational study. It carried out in Yaounde, at the Centre Pasteur of Cameroon from January 2010 to December 2019. Samples from patients with a clinical picture of a bloodstream infection were con ..read more
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