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Congenital syphilis: contemporary update on an ancient disease

Sexually Transmitted Infections

by Shiva, F., Freyne, B.

1M ago

Congenital syphilis, the neonatal infection caused by vertical transmission of the spirochete Treponema pallidum subsp pallidum is increasing globally. Congenital syphilis is entirely preventable through antenatal administration of Penicillin, but <70% of untreated pregnancies will result in an adverse birth outcome. Globally, gestational syphilis is the second leading infectious cause of stillbirth after malaria. Congenital syphilis may be apparent between birth and 12 weeks of age as a classical syndrome of rash, hepatosplenomegaly, jaundice, snuffles, thrombocytopenia and pseudoparesis b ..read more

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Research news in clinical context

Sexually Transmitted Infections

by Zace, D., Daskalopoulou, M., Tang, W.

1M ago

Strategies for evaluating penicillin allergy in STI services Over-reporting of penicillin or beta-lactam allergy often complicates STI management. In this trial, participants at low risk of allergy identified through a questionnaire were randomised to either (1) penicillin skin testing (PST), followed (if negative) by challenge with full-dose (250 mg) oral amoxicillin (PST arm, n=102), or (2) graded oral challenge (GOC), starting with 25 mg and following (if no reactions) with a full dose (GOC arm, n=104). In the PST arm, 99/102 (97%) participants proceeded to oral challenge and 96/99 (97%) ha ..read more

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Performance evaluation of a self-administered point-of-care test for anal HPV screening in PrEP users: data from a community-based PrEP service

Sexually Transmitted Infections

by Biasioli, L., Rossotti, R., Tavelli, A., De Bona, A., Tincati, C., Calzavara, D., Vinti, P., Baiguera, C., DAmico, F., Nava, A., Repossi, R., Bossolasco, S., Muccini, C., Mule, G., Tesoro, D., d'Arminio Monforte, A., Cernuschi, M., the Milano Check Point Group

1M ago

Objectives In this study, we compared the performance of a self-administered point-of-care test (POCT) for anal human papillomavirus (HPV) screening with laboratory gold-standard test in pre-exposure prophylaxis (PrEP) users and evaluated its feasibility. Methods We enrolled PrEP users from a local community-based PrEP service. Each participant self-collected an anal swab to test anal HPV with a PCR POCT capable of detecting 14 high-risk HPV genotypes. Anonymous questionnaires on self-sampling feasibility were completed. Participants were then referred to local clinics to undergo standard vira ..read more

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Characteristics and rates of infection by HIV in people receiving non-occupational post-exposure prophylaxis (nPEP) against HIV

Sexually Transmitted Infections

by Carrillo, I., Lopez de las Heras, M., Martinez, S. C., Prieto-Perez, L., Alvarez Alvarez, B., Waleed Al-Hayani, A., Suarez-Inclan, J. I., Fernandez, S. L., Luengo, P. Q., Diaz, M. E. A., Bernal Palacios, M., Mathews, P. A., Bonafont, B. S., Bravo Ruiz, R., Hernandez-Segurado, M., Gorgolas, M., Cabello, A.

1M ago

Introduction/objectives The use of non-occupational post-exposure prophylaxis (nPEP) emerges as a strategic intervention to reduce HIV infection risk following sexual encounters in our setting. Notwithstanding, there is a scarcity of contemporary data regarding adherence to this treatment, its effectiveness and tolerance. Our study aims to delve into these factors among individuals who have resorted to nPEP after high-risk sexual encounters. Methods We conducted a retrospective observational study of cases administered nPEP for HIV from 1 January 2018 to 31 December 2021 at a tertiary hospital ..read more

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Identifying priority groups for pre-exposure prophylaxis among sex workers in Flanders, Belgium: insights into routine HIV and sexually transmitted infection data in community-based clinics

Sexually Transmitted Infections

by Van Mieghem, H., Nöstlinger, C., Smekens, T., De Canniere, A.-S., Keersmaekers, K., Scheerder, G., De Baetselier, I., Vuylsteke, B.

1M ago

Objectives The burden of HIV and other sexually transmitted infections (STIs) remains high in sex workers globally, calling for strengthening targeted prevention strategies, including HIV pre-exposure prophylaxis (PrEP). The study’s objective was to assess HIV and STI burden among female, male and transgender sex workers in Flanders, Belgium, to guide targeting of PrEP strategies for sex workers. Methods We conducted a retrospective analysis of routine data collected between January 2016 and December 2019 by community-based organisations providing sexual healthcare services for sex workers in ..read more

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Impact of molecular ciprofloxacin resistance testing in management of gonorrhoea in a large urban clinic

Sexually Transmitted Infections

by Goldstein, E., Moss, E., Bennett-Slater, S., Ferguson, L., McInally, C., McHugh, M., Maxwell, A., Winter, A., Gunson, R. N.

1M ago

Objectives Antibiotic resistance in gonorrhoea is of significant public health concern with the emergence of resistance to last-line therapies such as ceftriaxone. Despite around half of Neisseria gonorrhoeae isolates tested in the UK being susceptible to ciprofloxacin, very little ciprofloxacin is used in clinical practice. Testing for the S91F mutation associated with ciprofloxacin resistance is now available in CE-marked assays and may reduce the requirement for ceftriaxone, but many patients are treated empirically, or as sexual contacts, which may limit any benefit. We describe the real-w ..read more

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Self-sampling with oral rinse to detect oropharyngeal Neisseria gonorrhoeae among men who have sex with men: results from an exploratory study in Belgium (the SSONG Study)

Sexually Transmitted Infections

by Vanbaelen, T., van Petersen, L., van Frankenhuijsen, M., Cuylaerts, V., Van den Bossche, D., Kenyon, C., De Baetselier, I.

1M ago

Objectives We aimed to assess whether a self-collected oral rinse was non-inferior to clinician-collected oropharyngeal swabs to detect Neisseria gonorrhoeae (Ng) using culture and nucleic acid amplification tests (NAAT) among men who have sex with men (MSM), and whether Ng may still be detected in oral rinses for a minimum of 5 days after collection. Methods MSM with a positive Ng result in an oropharyngeal or pooled sample (oropharynx, urethra and anorectum) were approached. Clinician-collected oropharyngeal swabs and oral rinses (15 mL sterile water) were taken. Ng culture and NAAT (Abbott ..read more

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In the fight against HIV/AIDS: the arduous implementation of government-funded pre-exposure prophylaxis programme in Taiwan

Sexually Transmitted Infections

by Huang, H. Y., Huang, J. R., Chan, P. C., Lee, C. C.

1M ago

Introduction The government-funded pre-exposure prophylaxis (PrEP) programme was targeted to those aged under 30 years or serodiscordant couples and implemented in September 2018–October 2020 in Taiwan. The study aimed to examine the effectiveness of the programme and the relationship between sexually transmitted disease (STD) and HIV seroconversion. Methods This study was a retrospective cohort analysis with questionnaires designed for participants who joined the aforementioned programme in the PrEP-designated hospitals. The questionnaires included sociodemographic factors, sexual risk behavi ..read more

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Reach of GetCheckedOnline among gay, bisexual, transgender and queer men and Two-Spirit people and correlates of use 5 years after program launch in British Columbia, Canada

Sexually Transmitted Infections

by Montiel, A., Ablona, A., Klassen, B., Card, K., Lachowsky, N. J., Brennan, D. J., Grace, D., Worthington, C., Gilbert, M.

1M ago

Objectives Understanding who uses internet-based sexually transmitted and blood-borne infection (STBBI) services can inform programme implementation, particularly among those most impacted by STBBIs, including gender and sexual minority (GSM) men. GetCheckedOnline, an internet-based STBBI testing service in British Columbia, Canada, launched in 2014. Our objectives were to assess reach, identify factors associated with use of GetCheckedOnline 5 years into implementation and describe reasons for using and not using GetCheckedOnline among GSM men. Methods The Sex Now 2019 Survey was an online, c ..read more

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Frequent chlamydia and gonorrhoea but very infrequent syphilis among men who have sex with men using HIV pre-exposure prophylaxis in West Africa

Sexually Transmitted Infections

by Dah, T. T. E., De Baetselier, I., Cuer, B., Anoma, C., Mensah, E., Kone, A., Diande, S., Dagnra, C. A., Faye-Kette, H. Y., Yeo, A., Yaya, I., Spire, B., Keita, B. D., Crucitti, T., Vuylsteke, B., Laurent, C., On behalf of the CohMSM-PrEP Study Group, CohMSM-PrEP Study Group, Laurent, Yaya, Ouedraogo, Granouillac, Cuer, Serrano, Peeters, Couderc, Spire, Sagaon-Teyssier, Mora, Maradan, Bourrelly, Berenger, Boyer, Castro, Riegel, Palvadeau, Vuylsteke, Baetselier, Reyniers, Crucitti, Keita, Diallo, Coulibaly, Maïga, Camara, Diarra, Ouologuem, Sangare, Keita, Cisse, Traore, Ouary, Kanta, Coulibaly, Anoma, Kouame, Kotchi, Aka, Lokrou, Coulibaly, Koffi, Nguessan, Yoro, Cisse, Dah, Traore, Rajaonarivelo, Ouedraogo, Ouedraogo, Coulibaly, Ouedraogo, Ilboudo, Traore, Comsiambo, Mensah, Agboyibor, Attisso, Kokouba, Badjassim, Agbomadji, Attiogbe, Yaka, Ekon, Bimba, Dagnra, Tegueni

1M ago

Objectives Although oral pre-exposure prophylaxis (PrEP) for HIV is being rolled out in West Africa, data on sexually transmitted infections (STIs) in PrEP users are scarce. We assessed the prevalence, incidence and determinants of bacterial STIs in men who have sex with men (MSM) taking PrEP in Burkina Faso, Côte d’Ivoire, Mali and Togo. Methods A prospective cohort study among MSM initiating PrEP as part of a comprehensive HIV prevention package was conducted between 2017 and 2021 in community-based clinics in the four study countries. Molecular screening for Chlamydia trachomatis (CT) and N ..read more

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