Inadequate plasma spike antigen does not drive poor severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine antibody response in kidney transplant recipients. Rather, a detectable spike likely indicates insufficient immune response to vaccination to rapidly clear vaccine antigens from blood. Abstract Background Kidney transplant recipients (KTRs) generate lower antibody responses to messenger RNA (mRNA)-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, yet precise mechanisms for this poor response remain uncertain. One potential cont ..read more

In this 5-year cohort of liver transplant recipients in Australia, the rate of surgical site infections was 8%. Surgical site infections were predominantly due to operation-related factors rather than patient- or antibiotic-related factors. Abstract Background Surgical site infection (SSI) after liver transplant (LT) is common, but no studies have been conducted in Australia. The purpose of this study was to determine the proportion of patients who developed an SSI post-LT in Australia's largest LT unit. Methods This was a single-center retrospective cohort study. We included all LT recipien ..read more

Abstract In this case, a 64-year-old male with a history of simultaneous orthotopic liver transplant and cadaveric renal transplant presented five years prior presented with persistent fevers two days after a positive SARS-CoV-2 nasal PCR. A CT scan of the chest on hospital day nine revealed innumerable 1–2 mm nodules in a miliary pattern throughout the lung. (1,3)-β-D-glucan on hospital day 11 was 133 pg/mL. In this article, the approach, diagnostic and management strategies for patients with persistent fevers after diagnosis of COVID-19 in a transplant recipient are discussed ..read more

Transplant Infectious Disease, EarlyView ..read more

Abstract A renal allograft abscess is a relatively rare condition. Appropriate antimicrobial therapy and drainage are recommended for treating renal abscesses. However, drainage can be challenging, depending on the location of the abscess. We present the case of a young female kidney transplant recipient who was successfully cured of a renal allograft abscess, using antimicrobial agents and appropriate follow-up imaging, without the need of any risky procedures ..read more

Transplant Infectious Disease, EarlyView ..read more

Fifty-three posthematopoietic stem cell transplant patients with coronavirus disease 2019 were reviewed between April 2020 and March 2023. Patients during the Omicron period were had more access to vaccines and antivirals compared to patients from the pre-Omicron period. Age, immunosuppression, and time from transplant were associated with hospital admission. Coinfections were associated with death. Abstract Background Hematopoietic stem cell transplant (HSCT) recipients are among patients with highest risk of adverse coronavirus disease 2019 (COVID-19) outcomes. Objective We compared clinic ..read more

No significant differences were found in the evolution of both groups of patients while comparing “pulse” to “low dose” groups, despite both were radically different in term of BK viral load and Banff score. Abstract Introduction As there is no specific antiviral treatment currently available for BK polyomavirus associated nephropathy (BKVAN), its management relies on immunosuppression reduction in kidney transplant patients. Data on efficacy of steroid pulses in this indication are lacking. Methods We performed a retrospective monocenter study on 64 patients diagnosed with biopsy-proven BKV ..read more

Transplant Infectious Disease, EarlyView ..read more

Abstract Background Norovirus (NoV) can cause chronic relapsing and remitting diarrhea in immunocompromised patients.  Few multicenter studies have described the clinical course, outcomes, and complications of chronic NoV in transplant recipients. Methods A multicenter retrospective study of adult and pediatric SOT and HSCT recipients diagnosed with NoV between November 1, 2017, and February 28, 2021. Data were obtained from electronic medical records (EMR) and entered into a central REDCap database. Descriptive statistics were calculated. Results A total of 280 NoV+ patients were identified ..read more