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BioMed Central » Immunity & Ageing

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Immunity & Ageing is a specialist open-access journal dedicated to increasing knowledge about the impact of aging on immune systems, the influence of aged immune systems on organismal well-being and longevity, and the potential for interventions to increase health span. At BMC, we are committed to continual innovation to better support the needs of our communities, ensuring the integrity of..

Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks

BioMed Central » Immunity & Ageing

by Anna Wadhwa, Maria Moreno-Villanueva, Brian Crucian and Honglu Wu

5d ago

Spaceflight poses a myriad of environmental stressors to astronauts´ physiology including microgravity and radiation. The individual impacts of microgravity and radiation on the immune system have been extensi ..read more

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Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis

BioMed Central » Immunity & Ageing

by Yanjing Huang, Zhong Liu, Mengke Li, Dongliang Wang, Jinguo Ye, Qiuling Hu, Qikai Zhang, Yuheng Lin, Rongxin Chen, Xuanwei Liang, Xingyi Li and Xianchai Lin

1w ago

Aging is associated with significant structural and functional changes in the spleen, leading to immunosenescence, yet the detailed effects on splenic vascular endothelial cells (ECs) and their immunomodulator ..read more

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Assessing serum anti-nuclear antibodies HEp-2 patterns in synucleinopathies

BioMed Central » Immunity & Ageing

by Jonas Folke, Marie Skougaard, Trine-Line Korsholm, Anne-Line Strange Laursen, Lisette Salvesen, Anne-Mette Hejl, Sara Bech, Annemette Løkkegaard, Tomasz Brudek, Sisse Bolm Ditlev and Susana Aznar

1w ago

This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies – Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared ..read more

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Yixin-Fumai granules modulate autophagy through the PI3K/AKT/FOXO pathway and lead to amelioration of aging mice with sick sinus syndrome

BioMed Central » Immunity & Ageing

by Lianzi Jin and Ping Hou

2w ago

By employing network pharmacology alongside molecular docking techniques, we can delve into the intricate workings of Yixin-Fumai granules (YXFMs) and their impact on sick sinus syndrome (SSS) within wrinkles ..read more

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Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction

BioMed Central » Immunity & Ageing

by Carola Ledderose, Eleftheria-Angeliki Valsami, Mark Elevado, Qing Liu, Brennan Giva, Julian Curatolo, Joshua Delfin, Reem Abutabikh and Wolfgang G. Junger

3w ago

The function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory complications in older individuals. The underlying causes are not fully understood. ATP rel ..read more

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Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19

BioMed Central » Immunity & Ageing

by Claudia Maria Trombetta, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Mattia Emanuela Ligotti, Serena Marchi, Emanuele Montomoli, Martin Mayora Neto, Nigel Temperton and Giuseppina Candore

3w ago

Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians. Two epidemiological study have shown that older cen ..read more

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Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics

BioMed Central » Immunity & Ageing

by Xuewen Deng and Hiroshi Terunuma

1M ago

The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated secretory phenotypes (SASPs). Unfortunately, immunosenescen ..read more

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Single-cell landscape of immunological responses in elderly patients with sepsis

BioMed Central » Immunity & Ageing

by Wanxue He, Chen Yao, Kaifei Wang, Zhimei Duan, Shuo Wang and Lixin Xie

1M ago

Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a special population influenced by immunosenescence, are more sus ..read more

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Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan

BioMed Central » Immunity & Ageing

by Tomoyuki Kakugawa, Yusuke Mimura, Yuka Mimura-Kimura, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano and Kazuto Matsunaga

1M ago

The magnitude and durability of cell-mediated immunity in older and severely frail individuals following coronavirus disease 2019 (COVID-19) vaccination remain unclear. A controlled immune response could be th ..read more

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Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice

BioMed Central » Immunity & Ageing

by Wenxin Wu, Jeremy S. Alexander, J. Leland Booth, Craig A. Miller, Jordan P. Metcalf and Douglas A. Drevets

1M ago

Age > 65 years is a key risk factor for poor outcomes after human influenza infection. Specifically, in addition to respiratory disease, non-neurotropic influenza A virus (IAV) causes neuro-cognitive complicat ..read more

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