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BMC Immunology

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BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.

Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy

BMC Immunology

by Takashi Kurashige, Rie Nakamura, Tomomi Murao, Naoko Mine, Mayu Sato, Riho Katsumata, Yuhei Kanaya, Yoriko Dodo, Tomohito Sugiura and Tomohiko Ohshita

2d ago

Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM). Though patients with IMNM were not considered to show skin rash, several reports have showed atypical skin conditions i ..read more

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GNUV201, a novel human/mouse cross-reactive and low pH-selective anti-PD-1 monoclonal antibody for cancer immunotherapy

BMC Immunology

by Hae-Mi Kim, Kyoung-Jin Kim, Kwanghyun Lee, Myeong Jin Yoon, Jenny Choih, Tae-Joon Hong, Eun Ji Cho, Hak-Jun Jung, Jayoung Kim, Ji Soo Park, Hye Young Na, Yong-Seok Heo, Chae Gyu Park, Heungrok Park, Sungho Han and Donggoo Bae

2d ago

Several PD-1 antibodies approved as anti-cancer therapies work by blocking the interaction of PD-1 with its ligand PD-L1, thus restoring anti-cancer T cell activities. These PD-1 antibodies lack inter-species ..read more

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Potential role of IGF-1R in the interaction between orbital fibroblasts and B lymphocytes: an implication for B lymphocyte depletion in the active inflammatory phase of thyroid-associated ophthalmopathy

BMC Immunology

by Renyan Wang, Delu Song, Yong Zhong and Hui Li

2d ago

Thyroid eye disease (TED) is an inflammatory process involving lymphocyte-mediated immune response and orbital tissue damage. The anti-insulin-like growth factor-1 receptor (IGF-1R) antibodies produced by B ly ..read more

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A novel chimeric vaccine containing multiple epitopes for simulating robust immune activation against Klebsiella pneumoniae

BMC Immunology

by Morteza Hakimian, Abbas Doosti and Ali Sharifzadeh

1w ago

Due to antibiotic resistance, the Klebsiella genus is linked to morbidity and death, necessitating the development of a universally protective vaccine against Klebsiella pathogens ..read more

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Atypical memory B cells increase in the peripheral blood of patients with breast cancer regardless of lymph node involvement

BMC Immunology

by Atefeh Azizi, Fereshteh Mehdipour, Morteza Samadi, Reza Rasolmali, Abdol-Rasoul Talei and Abbas Ghaderi

1w ago

Breast cancer is the most common cancer in females. The immune system has a crucial role in the fight against cancer. B and T cells, the two main components of the adaptive immunity, are critical players that ..read more

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The role of the immune system in early-onset schizophrenia: identifying immune characteristic genes and cells from peripheral blood

BMC Immunology

by Zi Chen, Yuxue Li, Yao Gao, Xiaoxuan Fan, Xinzhe Du, Xinrong Li, Zhifen Liu, Sha Liu and Xiaohua Cao

1w ago

Early-onset schizophrenia (EOS) is a type of schizophrenia (SCZ) with an age of onset of ..read more

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The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum

BMC Immunology

by NL Messina, M Wang, EK Forbes, B Freyne, WP Hasang, S Germano, R Bonnici, F Summons, K Gardiner, S Donath, R Gordon, SJ Rogerson and N Curtis

2w ago

Bacillus Calmette–Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these, murine and human studies suggest that BCG vaccination may protect against ..read more

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Basophil activation in insect venom allergy: comparison of an established test using liquid reagents with a test using 5-color tubes with dried antibody reagents

BMC Immunology

by Sebastian Waldherr, Miriam Hils, Martin Köberle, Knut Brockow, Ulf Darsow, Simon Blank, Tilo Biedermann and Bernadette Eberlein

2w ago

Flow cytometry-based basophil activation tests (BAT) have been performed with various modifications, differing in the use of distinct identification and activation markers. Established tests use liquid reagent ..read more

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Advanced in immunological monitoring of HIV infection: profile of immune cells and cytokines in people living with HIV-1 in Benin

BMC Immunology

by Yaou Pierrot Assogba, Adefounke Prudencia Adechina, Edmond Tchiakpe, Odilon Paterne Nouatin, René K. Kèkè, Moussa Bachabi, Honoré Sourou Bankole and Akadiri Yessoufou

3w ago

Immune cells and cytokines have been linked to viremia dynamic and immune status during HIV infection. They may serve as useful biomarkers in the monitoring of people living with HIV-1 (PLHIV-1). The present w ..read more

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Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis

BMC Immunology

by Maimonah Alghanmi, Faisal Minshawi, Tarfa A. Altorki, Ayat Zawawi, Isra Alsaady, Abdallah Y Naser, Hassan Alwafi, Soa’ad M. Alsulami, Ala A. Azhari, Anwar M Hashem and Rowa Alhabbab

3w ago

Helminth-derived proteins have immunomodulatory properties, influencing the host’s immune response as an adaptive strategy for helminth survival. Helminth-derived proteins modulate the immune response by induc ..read more

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