miRNA is involved in the regulation of liver injury caused by Echinococcus multilocularis infection. mmu-miR-30e-3p, mmu-miR-203-3p, mmu-miR-125b-5p, and mmu-miR-30c-2-3p may serve as potential diagnostic targets for liver injury. Abstract Objective To explore the role of miRNA in liver damage caused by Echinococcus multilocularis infection. Methods Six female C57BL mice were randomly divided into two groups, the control group and the infection group. Mice in the control group were injected with 100 μL PBS through the hepatic portal vein, and mice in the infection group were infected with E ..read more

Abstract Objective To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) level with novel inflammatory markers in hemodialysis-treated patients. Methods A total of 167 maintenance hemodialysis-treated patients were enrolled in this cross-sectional study. The patients were divided into vitamin D deficiency (a serum 25(OH)D level <20 ng/mL) and nondeficiency (a serum 25(OH)D level ≥20 ng/mL) groups. The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) were calculated by the complete blood cell count. The rel ..read more

The present study investigated the roles and mechanisms of TP53INP2 in spinal cord injury (SCI) rat model and in vitro model, and its mechanism. Results indicated that after spinal cord injury, TP53INP2 knockdown inhibits inflammatory response and apoptosis. TP53INP2 may be a potentially effective therapeutic target for SCI. Abstract Background Spinal cord injury (SCI) is a traumatic neurological disorder with limited therapeutic options. Tumor protein p53-inducible nuclear protein 2 (TP53INP2) is involved in the occurrence and development of various diseases, and it may play a role during S ..read more

We observed that natural killer cells in breast cancer have a higher potency to be recruited to the tumor site, but these cells, or at least some of their subsets, may not be able to render their cytotoxic effects. Abstract Background Natural killer (NK) cells, CD3− lymphocytes, are critical players in cancer immune surveillance. This study aimed to assess two types of CD3− NK cell classifications (subsets), that is, convectional subsets (based on CD56 and CD16 expression) and new subsets (based on CD56, CD27, and CD11b expression), and their functional molecules in the peripheral blood of p ..read more

The present findings may suggest that treatment with sotrovimab is more effective than molnupiravir in reducing mortality rate in COVID-19 patients. No significant difference was observed between the molnupiravir and sotrovimab in terms of hospitalization rate, death or hospitalization rate, and intensive care unit (ICU) admission. Molnupiravir was associated with higher incidence of adverse events. Abstract Background and Aim This systematic review and meta-analysis aimed to compare the effectiveness and safety of molnupiravir and sotrovimab in the treatment of patients with coronavirus dis ..read more

1.Serum vitamin A, E, and 25(OH)D3 were decreased in both autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC)/primary sclerosing cholangitis. 2.Serum vitamin C was reduced only in patients with PBC but not in AIH. 3.Most vitamins are deficient in autoimmune liver disease, and it is necessary to supplement vitamins in moderation. Abstract Objective Vitamins and homocysteine (Hcy) are involved in liver metabolism and related to the pathogenesis of autoimmune liver disease (AILD), but consensus is lacking. This study aims to systematically summarize relevant evidence to clarify the ..read more

Abstract We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL-13), IL-4, and IL-5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in the type 2 airway inflammation model, but IL-33 level in the lung was higher than in other models. IL-33 and interferon-γ (IFNγ) in lungs may control the severity of a type 2 airway inflammation in lung ..read more

Abstract Introduction Human leukocyte antigen-G (HLA-G) is a non-classical class I HLA molecule shown to regulate the immunomodulation of maternal immune cells to prevent fetal tissue destruction. Low levels of freely circulating maternal soluble HLA-G (sHLA-G) have been observed in pre-eclampsia, however, no pooled evidence exists. This meta-analysis aimed to generate pooled findings on the association of sHLA-G levels with pre-eclampsia and is the first study to perform a trimester-wise comparison of the levels of sHLA-G in preeclamptic cases and normal pregnant controls. Methods The databas ..read more

The oral microbial diversity of infants fed by gastric tube declined significantly over time. Firmicutes had replaced Proteobacteria as the predominant phylum at day of life 21. Abstract Aims The aim of the present study was to explore the effect of oropharyngeal mother's milk administration on oral microbial colonization in infants fed by gastric tube at different time points. Methods Infants (n = 116) with birth weight <1500 g were randomly allocated into two groups which both received breast milk for enteral nutrition. The control group (n = 51) accepted oropharyngeal normal saline adm ..read more

Research on drug hypersensitivity is in a rapid development stage and an emerging trend in reports of anaphylaxis to polyethylene glycols is identified. Developing algorithms for understanding the standardization process of culprit drugs, clinical manifestations, and diagnostic methods will be the focus of future direction. In addition, a better understanding of the mechanisms to culprit drugs with immunological precise phenotypic definitions and high-throughput platforms is needed. Abstract Background Drug hypersensitivity is a major global public health issue with a significant increase in ..read more