Scandinavian Journal of Immunology, Volume 99, Issue 5, May 2024 ..read more

Scandinavian Journal of Immunology, EarlyView ..read more

Importance of anti-golgi antibodies. Abstract Anti-Golgi antibodies are uncommon antibodies that exhibit specific, polarized cytoplasmic staining on the Hep-2 substrate. The objective of our study was to identify the clinical and laboratory features associated with anti-Golgi antibodies. We examined 4.5 years of data from a Turkish tertiary hospital in this retrospective cohort analysis. The indirect immunofluorescence staining patterns, antinuclear antibody (ANA) titres and clinical data of all patients were obtained from the hospital record system. A total of 146,055 ANAs were detected, of ..read more

Scandinavian Journal of Immunology, EarlyView ..read more

In a prospective cohort study of 50 elderly patients with pertrochanteric femur fractures treated by intramedullary nailing, followed for 1 year, we found a generalized increase in immunoglobulin levels including anti-nuclear antibodies, with no significant evidence of systemic autoimmunity. Abstract Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertroc ..read more

Scandinavian Journal of Immunology, Volume 99, Issue 4, April 2024 ..read more

Circulating Mucosal-associated invariant T-cells (MAIT) cells are significantly depleted in a broad spectrum of treatment-naïve haematological malignancies compared to sex and age-matched healthy subjects. In addition to their reduced numbers, MAIT cells acquire an activated/exhausted phenotype characterized by higher expression of HLA-DR, CD69, CD38 and PD-1. Abstract Mucosal-associated invariant T-cells (MAIT) are unconventional T-cells with cytotoxic and pro-inflammatory properties. Previous research has reported contradictory findings on their role in cancerogenesis with data being even ..read more

Serum samples from antiphospholipid syndrome patients were analysed by lectin microarray and validated by lectin blot. We found the unique expression of sugars binding SBA, LTL and SNA-I compared with the control groups. Abstract Antiphospholipid syndrome is a rare autoimmune disease characterized by persistent antiphospholipid antibodies. Immunoglobulin G plays a vital role in disease progression, with its structure and function affected by glycosylation. We aimed to investigate the changes in the serum immunoglobulin G glycosylation pattern in antiphospholipid syndrome patients. We applied ..read more

Autoantibody-positive breast cancer patients had longer progression-free survival and overall survival compared with autoantibody-negative cases. The presence of autoantibody was a potential independent prognostic predictor for breast cancer patients. Abstract The presence of autoantibodies is closely associated with the occurrence and development of cancer. Autoantibodies can be used as biomarkers for early breast cancer diagnosis. However, the relationship between autoantibodies and the prognosis of breast cancer patients remains elusive. This retrospective study aimed to investigate the c ..read more

ThGM cells express IL-2, TNF, CCL20, IFN-γ and GM-CSF to induce macrophages to produce pro-inflammatory mediators and form foam cells. However, oxidized low-density lipoprotein binds to CD69 and induces the expression of NR4A1 and NR4A2 in ThGM cells, subsequently down-regulating ThGM-associated cytokines and inhibiting the supportive effect on macrophages. Abstract T cells contribute to the pathogenesis of atherosclerosis. However, the presence and function of granulocyte-macrophage-colony-stimulating factor (GM-CSF)-producing T helper (ThGM) cells in atherosclerosis development is unknown ..read more