Paper Alert
European Journal of Gastroenterology & Hepatology
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2w ago
A selection of interesting papers that were published in the month before our press date in major journals likely to report important results in gastroenterology and hepatology ..read more
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Proton pump inhibitors are not associated with fundic gland polyps – a systematic review that takes into consideration all known confounders
European Journal of Gastroenterology & Hepatology
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2w ago
Sporadic fundic gland polyps (FGPs) progress, albeit rarely, to dysplasia and cancer. Two meta-analyses, including 8 and 11 studies, concluded that proton pump inhibitors (PPIs) were associated with FGPs. Intervention is considered unnecessary when FGPs have a background of PPIs use. Both meta-analyses, however, disregarded known confounders: age, sex, endoscopy indications, study design (prospective or retrospective), duration of PPI use, and H. pylori infection. Confounders are known to invalidate meta-analyses. We followed PRIXMA guidelines and searched the literature for studies on FGPs in ..read more
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Hematological ratios in patients with acute decompensation and acute-on-chronic liver failure: prognostic factors
European Journal of Gastroenterology & Hepatology
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2w ago
Background and aims Acute-on-chronic liver failure (ACLF) is the most severe form of acutely decompensated cirrhosis and is characterized by the presence of intense systemic inflammation. Leucocyte quantification can serve as an indirect indicator of systemic inflammation. In our study, we investigated the predictive value of hematological ratios (neutrophils to lymphocytes, monocyte to lymphocytes, platelets to lymphocytes, lymphocytes to C-reactive protein, and neutrophils to lymphocytes and platelets) in acute decompensation (AD) and ACLF patients and their relation to disease severity and ..read more
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Application of small bowel capsule endoscopy in children with Meckel’s diverticulum
European Journal of Gastroenterology & Hepatology
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2w ago
Background Meckel diverticulum (MD) is an important cause of gastrointestinal bleeding in children. Small bowel capsule endoscopy (SBCE) is a first-line examination method applied to patients with obscure gastrointestinal bleeding, but there are few studies on its application in children with MD. This article aims to provide evidence in favor of the auxiliary diagnosis of MD in children by analyzing its characteristics using SBCE. Methods We retrospectively collected the clinical data of patients with suspected MD. Results A total of 58 children were included in this study. All 58 children pre ..read more
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Clinical effects of chemical drugs, fecal microbiota transplantation, probiotics, dietary fiber, and acupuncture in the treatment of chronic functional constipation: a systematic review and network meta-analysis
European Journal of Gastroenterology & Hepatology
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2w ago
Currently, there are increasingly diverse treatment modalities for chronic functional constipation (CFC). This study aims to compare the relative efficacy and safety of chemical drugs, fecal microbiota transplantation (FMT), probiotics, dietary fiber, and acupuncture in the treatment of patients with CFC. We searched relevant randomized controlled trials (RCTs) published in five databases up to November 2023. Network meta-analysis (NMA) was carried out using R Studio 4.2.1. Cumulative ranking probability plots, assessed through the surface under the cumulative ranking (SUCRA), were employed to ..read more
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Antidepressant treatment in inflammatory bowel disease: a systematic review and meta-analysis
European Journal of Gastroenterology & Hepatology
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2w ago
Around 25% of patients with inflammatory bowel disease (IBD) have depressive symptoms, yet antidepressants have been poorly studied in IBD. We systematically searched IBD studies testing antidepressants in four databases. Outcomes were depressive symptoms, anxiety, IBD disease activity, quality of life (QoL) and adverse events. For randomized controlled trials (RCTs), we performed random-effects meta-analysis of the standardized mean difference (SMD) in posttreatment scores between antidepressant and placebo groups. Risk of bias was assessed using the Cochrane Common Mental Disorders Depressio ..read more
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Coexistence of metabolic-associated fatty liver disease and autoimmune or toxic liver disease
European Journal of Gastroenterology & Hepatology
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2w ago
Fatty liver disease (FLD) affects approximately 25% of global adult population. Metabolic-associated fatty liver disease (MAFLD) is a term used to emphasize components of metabolic syndrome in FLD. MAFLD does not exclude coexistence of other liver disease, but impact of coexisting MAFLD is unclear. We investigated prevalence and characteristics of MAFLD in patients with biopsy-proven autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), or toxic liver disease. Liver histopathology and clinical data from Helsinki University Hospital district (1.7 m ..read more
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Development and validation of risk prediction model for bacterial infections in acute liver failure patients
European Journal of Gastroenterology & Hepatology
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2w ago
Infections significantly increase mortality in acute liver failure (ALF) patients, and there are no risk prediction models for early diagnosis and treatment of infections in ALF patients. This study aims to develop a risk prediction model for bacterial infections in ALF patients to guide rational antibiotic therapy. The data of ALF patients admitted to the Second Hospital of Hebei Medical University in China from January 2017 to January 2022 were retrospectively analyzed for training and internal validation. Patients were selected according to the updated 2011 American Association for the Stud ..read more
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Nomogram predicting survival in patients with lymph node-negative hepatocellular carcinoma based on the SEER database and external validation
European Journal of Gastroenterology & Hepatology
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2w ago
Background The relationship between lymph node (LN) status and survival outcome in hepatocellular carcinoma (HCC) is a highly controversial topic. The aim of this study was to investigate the prognostic factors in patients without LN metastasis (LNM) and to construct a nomogram to predict cancer-specific survival (CSS) in this group of patients. Methods We screened 6840 eligible HCC patients in the Surveillance, Epidemiology and End Results(SEER)database between 2010 and 2019 and randomized them into a training cohort and an internal validation cohort, and recruited 160 patients from Zhongnan ..read more
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The cost implications of Wilson disease among hospitalized patients: analysis of USA hospitals
European Journal of Gastroenterology & Hepatology
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2w ago
Background and aim In this study, we used a national cohort of patients with Wilson’s disease (WD) to investigate the admissions, mortality rates, and costs over the captured period to assess specific subpopulations at higher burden. Methods Patients with WD were selected using 2016–2019 National Inpatient Sample (NIS). The weighted estimates and patient data were stratified using demographics and medical characteristics. Regression curves were graphed to derive goodness-of-fit for each trend from which R2 and P values were calculated. Results Annual total admissions per 100 000 hospitalizatio ..read more
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