Hui Yeong Oh, Hyun Ho Choi, Eui Jin Kim, Ji Hye Choi, Sung Sook Choi, Hae Kyung Lee, Hyung-Keun Kim, Sang Woo Kim, Won Sang H. Park, Hiun Suk Chae Saudi Journal of Gastroenterology 2023 29(1):53-58 Background: Methylene blue (MB) is used endoscopically to demarcate tumors and as a photosensitizer in photodynamic therapy (PDT). However, there are few in vivo studies about its toxicity in healthy stomach tissue. We performed sequential in vitro and in vivo analyses of MB-induced phototoxicity. Methods: We performed in vitro experiments using the AGS human gastric cancer cell line treated with ..read more

Rimlee Dutta, Ramakant Rawat, Prasenjit Das, Geetika Singh, Alka Kumari, Muzafer Ahmad, Ashish Chauhan, Vineet Ahuja, Sanjay K Agrawal, Govind K Makharia Saudi Journal of Gastroenterology 2023 29(1):59-65 Background: The causal association between IgA nephropathy (IgAN) and celiac disease (CeD) is based on their clinical coexistence. In this prospective study, we screened patients with IgAN for CeD and explored the utility of analysis of IgA anti-TG2 antibody deposits, for establishing a causal association. Methods: Biopsy-proven patients of IgAN were screened for serum IgA anti-tissue trans ..read more

Qi Sheng, Huanchen Shi, Shousheng Liu, Likun Zhuang, Zhenzhen Zhao, Yongning Xin Saudi Journal of Gastroenterology 2023 29(1):39-46 Background: Accumulated studies have shown that low expression of 25-hydroxyvitamin D [25(OH)D] was significantly associated with the risk of non-alcoholic fatty liver disease (NAFLD). However, the exact causality is still unknown. The aim of this study was to investigate whether levels of 25(OH)D are associated with risk of NAFLD, using a two-sample Mendelian randomization (MR). Methods: Data from a recent large vitamin D genome-wide association study (GWAS) on ..read more

Xin Su, Junlei Li, Lijuan Du, Yuzhen Wei, Haiyu Li, Haiqiang Sang Saudi Journal of Gastroenterology 2023 29(1):47-52 Background: Gastrointestinal bleeding (GIB) complicating acute myocardial infarction (AMI) is a severe clinical condition with treatment contradiction and poor prognosis. This study aimed to evaluate the rate of in-hospital mortality in patients with GIB who subsequently suffered from AMI and to explore the potential risk factors for this condition. Methods: In this retrospective study, a total of 77 patients diagnosed with GIB, who subsequently suffered from AMI, were enrolle ..read more

Rim Sghiri, Hana Ben Hassine, Adel Almogren, Zahid Shakoor, Mohammed Alswayyed Saudi Journal of Gastroenterology 2023 29(1):31-38 Background: The prevalence of celiac disease (CD) is relatively high in Saudi Arabia, and little is known about the accuracy of serological markers in the local population. This study aimed to assess the diagnostic performance of various serological markers for detecting CD in Saudi children and adults. Methods: We conducted a retrospective study of 148 CD patients and 512 controls to assess the diagnostic performances of IgA anti-tissue transglutaminase antibodie ..read more

Jing-Min Huang, Lv-Ping Zhuang, Hua-Gen Wang, Li-Ying Zhong, Sheng-Jin Xue, Fang-Xi Tian, Hua-Yang Lin Saudi Journal of Gastroenterology 2023 29(1):21-30 Background: This study aimed to develop and validate a radiomics score to predict the long-term survival and patterns of recurrence of gastric cancer (GC). Methods: A total of 513 patients who underwent radical gastrectomy for GC after curative resection between 2008 and 2016 at two institutions were analyzed. A radiomics score was generated using the least absolute shrinkage and selection operator Cox regression model on 327 patients and w ..read more

Chuanchao Xia, Liqi Sun, Lisi Peng, Fang Cui, Zhendong Jin, Haojie Huang Saudi Journal of Gastroenterology 2023 29(1):12-20 Background: Endoscopic retrograde cholangiopancreatography (ERCP) for patients with periampullary diverticulum (PAD) remains a challenge. This study aims to investigate the factors and techniques related to successful and safe ERCP in patients with PAD. Methods: We enrolled patients who underwent ERCP in a large tertiary center. The difficult cannulation rate, technical success rate, clinical success rate, and adverse events (AEs) rate were compared between patients wit ..read more

Hassan Mahmoudi, Hadi Hossainpour Saudi Journal of Gastroenterology 2023 29(1):3-11 Fecal microbiota transplantation (FMT) restores a balanced intestinal flora, which helps to cure recurrent Clostridium difficile infections (RCDI). FMT has also been used to treat other gastrointestinal diseases, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and chronic constipation, as well as a variety of non-GI disorders. The purpose of this review is to discuss gut microbiota and FMT treatment of GI and non-GI diseases. An imbalanced gut microbiota is known to predispose one ..read more

Tarek Z Arabi, Aymen Almuhaidb Saudi Journal of Gastroenterology 2023 29(1):1-2 ..read more

Abdulhamid A Alhadab, Shaden N AlMahamed, Ibrahim E Hassan, Abdelhai H Hammo Saudi Journal of Gastroenterology 2022 28(6):448-455 Background: Inflammatory bowel disease (IBD) is a chronic gastrointestinal tract disorder characterized by periods of exacerbations and remissions that affect multiple aspects of a pediatric patient's quality of life. The purpose of this study is to describe the health-related quality of life of Saudi pediatric IBD patients and to determine the influencing factors which can affect it. Methods: This is a single center cross-sectional descriptive study, cond ..read more