A Novel Treatment Approach to Treatment-Resistant, Recurrent Clostridium difficile
Case Reports in Gastroenterology
by S.Karger AG
2d ago
A 36-year-old male with a previous medical history of persistent Clostridium difficile presented to clinic for evaluation of diarrheal symptoms intermittently for the last 2 years. He reported recurrent episodes of C. difficile that initially began after prophylactic antibiotic use prior to a tooth extraction. He underwent 12 unsuccessful treatment trials at a nearby clinic with courses of vancomycin, metronidazole, and fidaxomicin. His chronic diarrhea had caused him to endure significant lifestyle alterations over the years. After multiple episodes of incomplete bacterial clearance, he was r ..read more
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Mixed Neuroendocrine Non-Neuroendocrine Neoplasm Arising in the Ectopic Gastric Mucosa of Esophagus
Case Reports in Gastroenterology
by S.Karger AG
2d ago
Esophageal neuroendocrine neoplasms are extremely rare, and their prognosis is poor. Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) are even more rare and are defined as tumors consisting of neuroendocrine carcinoma and either adenocarcinoma or squamous cell carcinoma. We report a rare case featuring endoscopic submucosal dissection (ESD) for an esophageal MiNEN, arising from the ectopic gastric mucosa in the lower thoracic esophagus. A 92-year-old male patient was referred to this hospital for investigation of an esophageal tumor. An endoscopic examination revealed a 10 mm elevate ..read more
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Left Perforated Colonic Tumor with Synchronous Locally Advanced Right Colonic Tumor
Case Reports in Gastroenterology
by S.Karger AG
2d ago
Colorectal cancer is one of the most common malignant neoplasms worldwide. Overall mortality is 33%. Synchronous colorectal cancer refers to more than one malignant tumor detected in different segments of the colon, simultaneously or within 6 months of initial diagnosis. The development of colorectal cancer is a multistep process that originates with a genetic mutation leading to a malignant phenotype and generating a growth advantage. Colorectal cancer presents up to 16% of hypermutations, of which 75% are characterized by microsatellite instability which in turn leads to poorer cell differen ..read more
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Efficacy of Infliximab for the Treatment of Oral Manifestation of Crohn’s Disease
Case Reports in Gastroenterology
by S.Karger AG
1w ago
Oral manifestations of IBD can be specific or nonspecific, due to intestinal malabsorption or induced by pharmacological treatments. Oral manifestations may precede the diagnosis of IBD or interfere with timely diagnosis and treatment. The paradigm of treatment for oral lesions in patients with IBD is based on treating and controlling the intestinal manifestations of the underlying disease as well as local methods of treatment can be used. Here, we report a case of a patient with the oral manifestation of IBD, who responded to treatment with infliximab. The patient was admitted with complaints ..read more
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Microscopic Colitis with Escitalopram Use and New Onset Vitiligo
Case Reports in Gastroenterology
by S.Karger AG
1w ago
Microscopic colitis is a common cause of chronic diarrhea, particularly in patients with autoimmune disorders. Colonic mucosa appears normal and only shows inflammation on histological examination. There are two histological variations of microscopic colitis. It has been associated with several drug classes, and certain drugs are associated with one variation or another. In this case report, we discuss the case of a patient who is on a drug not previously associated with her variation of microscopic colitis and who has an autoimmune condition whose relationship to microscopic colitis is not we ..read more
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Diffuse Metastatic Melanoma in the GI Lumen Following Immune Checkpoint Inhibitor Colitis Treatment
Case Reports in Gastroenterology
by S.Karger AG
1M ago
We describe the unique case of a 73-year-old man who developed diffuse metastatic melanoma throughout the GI tract following potent immunosuppressive treatment for his immune-mediated colitis. Diagnosis of his metastatic GI luminal disease was confirmed with colonoscopy and EGD biopsies. Immunosuppressive therapy including corticosteroids and vedolizumab is the mainstay treatment for immune-mediated colitis and has generally been thought to have a safe toxicity profile. This unique case of diffuse luminal metastasis of melanoma after intensive immunosuppressant treatment raised the concern of ..read more
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Drug-Induced Liver Injury from Herbal Liver Detoxification Tea
Case Reports in Gastroenterology
by S.Karger AG
1M ago
The increasing consumption of unregulated herbal and dietary supplements has presented clinicians with new challenges in assessing and managing acute liver injury. Patients may present in various ways ranging from asymptomatic transaminitis to acute liver failure. Several natural products have been found to mitigate drug-induced liver injury, which has led to the creation of numerous registries to outline all its aspects further. We describe the case of a 36-year-old female who developed a clinically significant acute liver injury with a cholestatic pattern due to an over-the-counter herbal li ..read more
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Esophago-Pleural Fistula Complicating a Laparoscopic Adjustable Gastric Band
Case Reports in Gastroenterology
by S.Karger AG
1M ago
Laparoscopic adjustable gastric banding was previously a commonly performed bariatric procedure. However, in recent years, the procedure has become less commonly performed. Long-term complications nonetheless persist and continue to be seen in clinical practice. We present a case of an esophago-pleural fistula complicating a longstanding laparoscopic adjustable gastric band in a woman presenting with persistent empyema. Palliative esophageal stenting was successfully performed, and the patient was discharged home on hospice care per her family’s wishes. Case Rep Gastroenterol 2022;16:607–611 ..read more
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Gastrointestinal Bleeding from Dieulafoy’s Lesion in the Cecum
Case Reports in Gastroenterology
by S.Karger AG
1M ago
Dieulafoy’s lesion is a rare cause of gastrointestinal (GI) bleeding comprising approximately 2% of all acute GI bleeds. It is an abnormal submucosal artery that has a tortuous course before protruding through the mucosa and leading to hemorrhage. Dieulafoy’s lesions are most commonly located in the upper GI tract within the lesser curvature of the stomach. Lower GI tract Dieulafoy’s lesions are remarkably rare. Our case describes an elderly gentleman who presented with fatigue and dyspnea several days prior to experiencing any evidence of GI bleeding. Initial laboratory investigation revealed ..read more
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Recurrent Cholangitis Secondary to a Traumatic Biliary Neuroma
Case Reports in Gastroenterology
by S.Karger AG
1M ago
Biliary amputation neuroma is rare and difficult to diagnose preoperatively due to diversity of clinical presentation and a lack of awareness among healthcare providers. We present a case of biliary neuroma arising from a recent laparoscopic cholecystectomy, complicated by bile leak and recurrent cholangitis. An extensive review of the literature was performed, closely examining related etiology, trends in age, clinical symptomology, and time to presentation. The role of surgery compared to an endoscopic approach in diagnosis has been reviewed. Physicians are urged to remain mindful of maligna ..read more
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