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Annals of Gastroenterology
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Impact of aspirin on pancreatic cancer
Annals of Gastroenterology
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3w ago
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Clinical features and outcomes of total pancreatic lipomatosis with chronic pancreatitis: a case series
Annals of Gastroenterology
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3w ago
Background Fatty changes in the pancreas are common, whereas total pancreatic lipomatosis (PL) is rare. Commonly associated with various components of metabolic syndrome and metabolicassociated steatotic liver disease, total PL can have various etiologies and can manifest with severe pancreatic exocrine insufficiency. Method We retrospectively analysed the clinical profile and management outcomes of 8 patients (mean age: 37.1 years; 5 male) with total PL seen at a tertiary care center over the last 15 years. Results All patients presented with abdominal pain and had coexistent chronic pancreat ..read more
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Validation of gender-equity model for liver allocation (GEMA) and its sodium variant (GEMA-Na) in candidates for liver transplantation
Annals of Gastroenterology
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3w ago
Background The current allocation system for liver transplantation (LT) is based on the sickestfirst policy, using objective variables to ensure equal priority. However, under-prioritization of female patients for LT, compared to males, is well demonstrated and new scores have been proposed to overcome this systematic bias. This study evaluated the ability of these new scores to predict the long-term outcomes of patients with cirrhosis. Methods The clinical and laboratory characteristics of 694 consecutive candidates for liver transplantation from 2 liver transplant centers were recorded. The ..read more
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The treatment interventions and targets of cancer cachexia research during the past decade: a systematic review of the literature
Annals of Gastroenterology
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3w ago
Background Cachexia is a detrimental multifactorial syndrome that has been strongly associated with cancer. A growing body of data concerning its management is being generated from the ongoing advances of experimental cancer cachexia research. This study aimed to delineate the broad landscape of cancer cachexia research, by comprehensively presenting the treatment interventions and targets of cancer cachexia during the past decade. Methods A systematic literature search was performed in Medline and Scopus databases from January to April 2023. Articles were considered eligible if they described ..read more
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Gastrointestinal cancer incidence after lung transplantation in sarcoidosis patients
Annals of Gastroenterology
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3w ago
Background The risk of gastrointestinal (GI) cancer after lung transplantation (LTx) in sarcoidosis patients is not well defined. Given the cancer risks linked to sarcoidosis and organ transplantation, this study investigated the incidence of GI de novo malignancies (DNM), comparing LTx recipients with sarcoidosis or idiopathic pulmonary fibrosis (IPF). Methods We analyzed data from the United Network for Organ Sharing registry, including adults with sarcoidosis or IPF who underwent LTx between May 2005 and December 2018. The primary outcome was the incidence of GI DNM by March 2023. Results O ..read more
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Immune checkpoint inhibitor-associated gastrointestinal adverse events in patients with colorectal cancer
Annals of Gastroenterology
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3w ago
Background Immune checkpoint inhibitors (ICI) target microsatellite instability-high (MSI-H) tumors with success. The incidence and characteristics of ICI-related colitis (IMC) in patients with MSI-H colorectal cancers (CRC) are unclear. Methods We performed a retrospective analysis of adult patients with CRC who received ICI between June 1, 2014, and December 31, 2022, including data on IMC observed up to 3 months after the last dose of ICI. Patients’ demographics, oncologic profile, endoscopic features, treatment and clinical outcomes were evaluated. Results Of 474 patients with CRC receivin ..read more
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Diverticulosis and neoplastic lesions in screening colonoscopy: a large, multicenter study
Annals of Gastroenterology
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3w ago
Background Data on the potential association between diverticulosis and colonic neoplastic lesions are still controversial. We investigated this issue in subjects who underwent screening colonoscopy. Methods We reviewed the data of subjects with a positive fecal immunological test who underwent a first colonoscopy in the national colorectal screening program. Endoscopic and histological reports were evaluated, using both univariate and multivariate analyses to search for an association between diverticulosis and colonic neoplastic lesions. Results Data from 5050 subjects (males: 52.2%; mean ag ..read more
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Endoscopic management of ileal pouch–anal anastomosis strictures: meta-analysis and systematic literature review
Annals of Gastroenterology
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3w ago
Background Restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) is a common surgical procedure for ulcerative colitis and familial adenomatous polyposis. IPAA strictures are a known complication, often requiring surgical intervention. Endoscopic interventions offer a less invasive alternative, but their safety and efficacy remain uncertain. Methods A comprehensive literature search was performed to identify pertinent studies. Outcomes assessed were technical success, clinical success (immediate and end of follow up), pouch failure rate and adverse events. Pooled estimates were ..read more
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Impact of pericarditis on cardiovascular complications and healthcare utilization in patients with inflammatory bowel disease: a National Inpatient Sample study
Annals of Gastroenterology
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3w ago
Background Inflammatory bowel disease (IBD), which affects over 2.3 million people in the USA, involves chronic gut inflammation and can lead to cardiovascular complications, including pericarditis. Whether pericarditis in IBD patients is caused by medication, or by the disease itself, remains unclear. Our study aimed to determine the prevalence of pericarditis in IBD and its impact on cardiac complications, outcomes and resource utilization. Methods NIS data were obtained for IBD patients from 2016-2020. Outcomes were assessed using multivariate logistic regression, adjusting for demographics ..read more
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