Hepatitis E infection in chronic liver disease patients causing acute on chronic liver failure: Vaccination is need of the hour
BMJ Open Gastroenterology
by Ullah, K., Dogar, A. W., Ochani, S., Ahmad, H. B.
6d ago
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Prevalence of frailty in patients with non-cirrhotic non-alcoholic fatty liver disease
BMJ Open Gastroenterology
by O'Brien, A.
1w ago
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Acute appendicitis and ulcerative colitis: a population-based sibling comparison study
BMJ Open Gastroenterology
by Garcia-Argibay, M., Hiyoshi, A., Montgomery, S.
1w ago
Objective To assess the inverse relationship between acute appendicitis and ulcerative colitis (UC) using a sibling comparison design to adjust for unmeasured familial genetic and environmental factors. Design The cohort comprised 3.1 million individuals resident in Sweden between 1984 and 2018 with the linkage of several Swedish national registers. Fitting Cox hazards models, we calculated the risk for developing UC in individuals with and without acute appendicitis by the age 20 years adjusting for several potential confounding factors. Further, we performed sibling-stratified analyses to ad ..read more
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Feasibility, safety and tolerability of the CREB-binding protein/{beta}-catenin inhibitor OP-724 in patients with advanced primary biliary cholangitis: an investigator-initiated, open-label, non-randomised, two-centre, phase 1 study
BMJ Open Gastroenterology
by Kimura, M., Ogawa, E., Harada, K., Imamura, J., Saio, M., Ikura, Y., Yatsuhashi, H., Murata, K., Miura, K., Ieiri, I., Tanaka, A., Kimura, K.
1w ago
Objective This study aimed to evaluate the safety and tolerability of OP-724, a CREB-binding protein/β-catenin inhibitor, in patients with advanced primary biliary cholangitis (PBC). Design An open-label, non-randomised, phase 1 trial was conducted at two hospitals in Japan. Patients with advanced PBC classified as stage III or higher according to the Scheuer classification by liver biopsy between 4 September 2019 and 21 September 2021 were enrolled. Seven patients received intravenous OP-724 infusions at escalating dosages of 280 and 380 mg/m2/4 hours two times weekly for 12 weeks. The primar ..read more
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Patient satisfaction after remotely delivered gut-directed hypnotherapy for irritable bowel syndrome during the COVID-19 era: implications for future practice
BMJ Open Gastroenterology
by Noble, H., Hasan, S. S., Simpson, V., Whorwell, P. J., Vasant, D. H.
1w ago
Objective Gut-directed hypnotherapy (GDH) is an evidence-based treatment for irritable bowel syndrome (IBS). Adoption of remote GDH has been accelerated by the COVID-19 pandemic. We aimed to evaluate patient experience and satisfaction following remote GDH. Design On completing 12 sessions of remote GDH via Skype using the Manchester protocol, patients with refractory IBS completed a feedback form on their experience. The proportion reporting positive outcomes (≥30% improvement in global IBS symptoms or abdominal pain, satisfaction, recommendation to family/friends) were compared by patient fa ..read more
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Measurement of clinical delay intervals among younger adults with colorectal cancer using health administrative data: a population-based analysis
BMJ Open Gastroenterology
by Castelo, M., Paszat, L., Hansen, B. E., Scheer, A. S., Faught, N., Nguyen, L., Baxter, N. N.
2w ago
Background Clinical delays may be important contributors to outcomes among younger adults (<50 years) with colorectal cancer (CRC). We aimed to describe delay intervals for younger adults with CRC using health administrative data to understand drivers of delay in this population. Methods This was a population-based study of adults <50 diagnosed with CRC in Ontario, Canada from 2003 to 2018. Using administrative code-based algorithms (including billing codes), we identified four time points along the pathway to treatment—first presentation with a CRC-related symptom, first investigation ..read more
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Evaluation of 30-day mortality in patients undergoing gastrointestinal endoscopy in a tertiary hospital: a 3-year retrospective survey
BMJ Open Gastroenterology
by Chatelanat, O., Spahr, L., Bichard, P., Bochatay, L., Goossens, N., Bastid, C., Frossard, J.-L.
1M ago
Objective Despite international guidelines recommendations to use mortality as a quality criterion for gastrointestinal (GI) procedures, recent studies reporting these data are lacking. Our objective was to report death causes and rate following GI endoscopies in a tertiary university hospital. Design We retrospectively reviewed all GI procedures made between January 2017 and December 2019 in our tertiary hospital in Switzerland. Data from patients who died within 30 days of the procedure were recorded. Results Of 18 233 procedures, 251 patients died within 30 days following 345 (1.89%) proced ..read more
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Identifying and understanding disease burden in patients with inflammatory bowel disease
BMJ Open Gastroenterology
by Christensen, K. R., Ainsworth, M. A., Skougaard, M., Steenholdt, C., Buhl, S., Brynskov, J., Kristensen, L. E., Jorgensen, T. S.
1M ago
Objective Physicians tend to focus on biomedical targets while little is known about issues important to patients. We aimed to identify critical concepts impacting patients with inflammatory bowel disease (IBD). Design We performed a survey of patients with IBD in biologic therapy (n=172) and used a validated qualitative method called group concept mapping (GCM) in patient workshops. The survey included 13 questions on attitudes toward symptoms and issues related to IBD. In the eight workshops, patients (n=26) generated statements later clustered into concepts identifying issues impacting a pa ..read more
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Live vaccinations for infants exposed to maternal infliximab in utero and via breast milk - the need for nuanced decision making
BMJ Open Gastroenterology
by Selinger, C. P., Bel Kok, K., Limdi, J. K., Kent, A., Cooney, R., Nelson-Piercy, C.
2M ago
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Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential applications in human health and disease
BMJ Open Gastroenterology
by Preethy, S., Ikewaki, N., Levy, G. A., Raghavan, K., Dedeepiya, V. D., Yamamoto, N., Srinivasan, S., Ranganathan, N., Iwasaki, M., Senthilkumar, R., Abraham, S. J. K.
2M ago
Objective The gut microbiome and its metabolites are influenced by age and stress and reflect the metabolism and health of the immune system. We assessed the gut microbiota and faecal metabolome in a static animal model of non-alcoholic steatohepatitis (NASH). Design This model was subjected to the following treatments: reverse osmosis water, AFO-202, N-163, AFO-202+N-163 and telmisartan treatment. Faecal samples were collected at 6 and 9 weeks of age. The gut microbiome was analysed using 16S ribosomal RNA sequences acquired by next-generation sequencing, and the faecal metabolome was analyse ..read more
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