![BMJ Open Gastroenterology](https://i1.feedspot.com/5258038.jpg?t=1615889808)
BMJ Open Gastroenterology
43 FOLLOWERS
BMJ Open Gastroenterology is an online-only, peer-reviewed, open-access journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology and hepatology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. BMJ Open Gastroenterology adheres to..
BMJ Open Gastroenterology
17h ago
Objective
Cholecystectomy is one of the most frequently performed surgeries in Germany and is performed as a treatment of acute cholecystitis (guideline S3 IIIB.8) and after endoscopic retrograde cholangiopancreatography for choledocholithiasis with simultaneous cholecystolithiasis (guideline S3 IIIC.6). This article examines the effects of a guideline update from 2017, which recommends prompt cholecystectomy within 24 hours of admission due to cholecystitis or within 72 hours after bile duct repair. In addition, it aims to identify reasons (eg, financial disincentives) and potential for impro ..read more
BMJ Open Gastroenterology
1w ago
Objective
To identify the optimal incentive protocol for maximising participation while managing study costs during the Voyage trial.
Design
Prospective cohort (Voyage trial) of colorectal cancer (CRC) incidence and mortality outcomes in individuals screened with multitarget stool DNA (mt-sDNA) served as the population. A subset was randomised to receive postage stamps as a pre-consent incentive, or as a post-consent incentive after completion of the consent and questionnaire. Descriptive statistics from year 1 are reported.
Results
During year 1 of the Voyage trial, a total of 600 258 individ ..read more
BMJ Open Gastroenterology
1w ago
Objective
We aimed to determine the association of statins with progression to a high risk for advanced fibrosis in primary care patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Design
This retrospective cohort study of electronic health record data included patients with MASLD and an initial low or indeterminate risk for advanced fibrosis, determined by Fibrosis-4 Index (FIB-4) score (<2.67). Patients were followed from the index FIB-4 until the primary outcome of a high-risk FIB-4 (≥2.67) or the end of the study period. Prescription for a statin during follo ..read more
BMJ Open Gastroenterology
2w ago
Background
Pancreatic cystic neoplasms (PCN) are considered premalignant conditions to pancreatic adenocarcinoma with varying degrees of cancerous potential. Management for individuals who do not require surgical treatment involves surveillance to assess for cancerous progression. Little is known about patients’ experience and the impact of living with surveillance for these lesions.
Aims
To explore the experiences of patients living with surveillance for PCNs.
Methods
Semi-structured qualitative interviews were conducted with patients under surveillance for pancreatic cystic neoplasms in the ..read more
BMJ Open Gastroenterology
1M ago
Objective
To estimate the strength of association between exposure to selected classes of prescribed medications and the risk of developing iron deficiency anaemia (IDA), specifically considering oral anticoagulants (OACs), antidepressants, antiplatelet agents, proton pump inhibitors (PPIs) and non-steroidal anti-inflammatories.
Design
A case–control study involving the analysis of community repeat prescriptions among subjects referred with IDA, and unmatched controls referred as gastroenterology fast-tracks for other indications. Multivariable logistic regression modelling was used to calcula ..read more
BMJ Open Gastroenterology
1M ago
Objective
To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventing morbidity and mortality.
Design
Data for adults with IBD diagnosed before the 1 September 2018 were extracted from the Clinical Practice Research Datalink Gold. We calculated the proportion of people vaccinated against seasonal influenza in the 2018–2019 influenza cycle. To investigate vaccine effectiveness, we calculated the propensity score (PS ..read more
BMJ Open Gastroenterology
1M ago
Introduction
The management of non-alcoholic steatohepatitis (NASH) is an unmet clinical need. Misoprostol, a structural analogue of naturally occurring prostaglandin E1, has been reported to decrease proinflammatory cytokine production and may have a potential role in treating NASH. We aimed to evaluate the efficacy and safety of misoprostol in treating patients with NASH.
Methods
In this phase 2, double-blind, randomised, placebo-controlled trial, patients with NASH were randomly assigned in a 1:1 ratio to receive 200 µg of misoprostol or placebo thrice daily for 2 months. The primary endpoi ..read more
BMJ Open Gastroenterology
1M ago
Objective
Patients with coeliac disease (CD) need to follow a strict gluten-free diet to manage symptoms and prevent complications. Restrictions imposed by the diet can be challenging and affect quality of life (QoL). We explored sources of variation in QoL among patients with CD.
Design
We conducted an online survey of coeliac patients in the UK, including a CD-specific QoL tool (CD-QOL V.1.0), questions on diet adherence and an optional comment box at the end. The survey was disseminated via social media and went live between January and March 2021. We performed multiple linear regression an ..read more
BMJ Open Gastroenterology
2M ago
Background
Timely diagnosis and treatment of inflammatory bowel disease (IBD) may improve clinical outcomes.
Objective
Examine associations between time to diagnosis, patterns of prior healthcare use, and clinical outcomes in IBD.
Design
Using the Clinical Practice Research Datalink we identified incident cases of Crohn’s disease (CD) and ulcerative colitis (UC), diagnosed between January 2003 and May 2016, with a first primary care gastrointestinal consultation during the 3-year period prior to IBD diagnosis. We used multivariable Cox regression to examine the association of primary care cons ..read more
BMJ Open Gastroenterology
2M ago
Objective
Dieulafoy’s lesions (DLs) are a rare but potentially life-threatening source of gastrointestinal (GI) haemorrhage. They are responsible for roughly 1%–6.5% of all cases of acute non-variceal GI bleeding.
Here, we describe retrospectively the clinical and endoscopic features, review the short-term and long-term outcomes of endoscopic management of bleeding DLs and we identify rate and risk factors, of recurrence and mortality in our endoscopic unit.
Design
Data were collected from patients presenting with GI haemorrhagic secondary to DLs between January 2018 and August 2023. Patients ..read more