Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping
Journal of Neurogastroenterology and Motility
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1M ago
Simultaneous bioelectrical and video mapping method. (A) Arrangement of the cross-polarized camera setup and the electrode array on the intestine. Camera exposure is recorded along with the bioelectrical signals by the BioSemi ActiveTwo system for synchronization. (B) Flexible electrode array used for high-resolution (HR) bioelectrical mapping (16 × 8 configuration; 4 mm spacing). (C) Intestine as visible from the camera, placed over the flexible electrode array. LED, light emitting diode ..read more
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Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial
Journal of Neurogastroenterology and Motility
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1M ago
Biomarker identification of responders to probiotic treatment. The potential biomarkers identified by the linear discriminant analysis (LDA) effect size algorithm are shown with heatmaps of the log-scaled relative abundance. Each plot represents biomarkers of the responders and non-responders in the (A) pre-treatment samples and (B) post-treatment samples and (C) biomarkers of the pre- and post-treatment samples in the responder group ..read more
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Predicting Responsiveness to Biofeedback Therapy Using High-resolution Anorectal Manometry With Integrated Pressurized Volume
Journal of Neurogastroenterology and Motility
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1M ago
Four categories of integrated pressurized volumes (IPVs) from the rectum to the anal canal. (A) Categorization of the pressure signals during simulated evacuation from the rectum to the anus into 5 regions. (B-E) IPVs from the lower portion (blue), upper portion (red), and the IPV ratio ..read more
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Estimating Probability for Esophageal Obstruction: A Diagnostic Decision Support Tool Applying Machine Learning to Functional Lumen Imaging Probe Panometry
Journal of Neurogastroenterology and Motility
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1M ago
Probability for esophagogastric junction (EGJ) obstruction using functional lumen imaging probe (FLIP) panometry metrics. Four patients (A-D) from the study cohort are plotted based on the EGJ-distensibility index (DI) and maximum EGJ-diameter from FLIP panometry as described in the text. Figure used with permission from the Esophageal Center of Northwestern (available from URL ..read more
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Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options
Journal of Neurogastroenterology and Motility
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1M ago
Stepwise events involved in stress induced localized inflammation and barrier dysfunction. ➊ Stress induced autonomic nerve stimulation, release of peripheral corticotropin-releasing factor (CRF) and muscularis macrophages receptors activation, further strengthened by damage associated molecular patterns (DAMPs) mediated immune cells activation. ➋ Nuclear activation and release of pro-inflammatory chemokines and cytokines. ➌ Upregulation of intercellular adhesion molecules-1 (ICAM-1) in the endothelial cells of blood vessels. ➍ Influx of leukocytes in the muscularis. ➎ Increase synthesis of in ..read more
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A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease
Journal of Neurogastroenterology and Motility
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5M ago
Natural history and pathological anatomy of the murine megacolon. Control and infected groups were evaluated in the acute phase (AP; 11 days) and chronic phases (CP; 3, 7, 12, and 15 months post-infection [m.p.i]) of infection. (A) control acute phase (CAP), (B) infected acute phase (IAP), (C) infected chronic phase 3 m.p.i. (ICP3), (D) infected chronic phase 7 m.p.i. (ICP7), (E) control chronic phase 12 m.p.i. (ICP12), (F) control chronic phase 15 m.p.i. (ICP15). For images (A) to (F), arrows: inflammatory infiltrate; asterisk: muscle degeneration; dashed line: thickness of the circular smoot ..read more
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The Predictive Value of Intraoperative Esophageal Functional Luminal Imaging Probe Panometry in Patients With Achalasia Undergoing Peroral Endoscopic Myotomy: A Single-center Experience
Journal of Neurogastroenterology and Motility
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5M ago
Process for the conversion of functional luminal imaging probe (FLIP) data to 3-dimensional panometry data. (A) Based on FLIP data obtained from each channel of the probe, the values of each channel are shown in a 2-dimensional plot. The x-axis shows the procedure time (second), and the y-axis shows the diameter (mm) of each channel. (B) The measured diameter data were used to convert FLIP data to 3-dimensional panometry data, and the diameter between each channel was interpolated by the spline method. The spline interpolation method performs interpolation by making interpolation functions of ..read more
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The Upper Esophageal Sphincter Distensibility Index Measured Using Functional Lumen Imaging Probe Identifies Defective Barrier Function of the Upper Esophageal Sphincter
Journal of Neurogastroenterology and Motility
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5M ago
Placement of functional lumen imaging probe (FLIP) catheter across upper esophageal sphincter (UES) and real-time data output is shown. CSA, cross-sectional area ..read more
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Efficacy of Slow Nutrient Drinking Test for Evaluating Postprandial Distress Symptom in Japanese Patients With Functional Dyspepsia
Journal of Neurogastroenterology and Motility
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5M ago
The test ending time. (A) Scatter diagrams of the test ending time. (B) Rate of participants who passed each time point in both groups. Open columns indicate the group of healthy participants. Closed columns indicate the group of patients with functional dyspepsia (FD ..read more
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Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction
Journal of Neurogastroenterology and Motility
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5M ago
Enterochromaffin (EC) cells dynamics in gut physiology and disorders of gut-brain interactions. (A) Heterogenous distribution of EC cells. (B-D) Functional heterogeneity of EC cells. Small intestine EC cells are specialized for sensing nutrients and colonic EC cells for gut microbiota and its derived molecules. (E, F) Apical and basolateral interface of EC cells. EC cells coordinate bilateral communication through crosstalk between dietary, microbial, and inflammatory factors to which their apical surface is exposed and to enteric neurons with afferent endings close to their basolateral surfac ..read more
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