Multimorbidity of Allergic Diseases Is Associated With Functional Gastrointestinal Disorders in a Young Japanese Population
Journal of Neurogastroenterology and Motility
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2M ago
The association between number of allergy diseases and the prevalence of functional gastrointestinal disorders. FD, functional dyspepsia; IBS, irritable bowel syndrome ..read more
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Effect of Trimebutine and Rifaximin on Breath Hydrogen and Methane by Glucose Breath Test in Patients With Functional Bloating: A Randomized Double-blind Clinical Trial
Journal of Neurogastroenterology and Motility
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2M ago
The profiles of the glucose breath test before and after treatment: hydrogen (H ) concentrations in rifaximin group (A) and rifaximin plus trimebutine maleate group (B); methane (CH ) concentrations in rifaximin group (C) and rifaximin plus trimebutine maleate group (D ..read more
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Altered Esophageal Smooth Muscle Phenotype in Achalasia
Journal of Neurogastroenterology and Motility
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2M ago
Intramuscular collagen staining is significantly increased in the circular smooth muscle (CSM) layer of the esophagus in achalasia. (A-C) Representative images of histochemistry for detection of collagen using Sirius Red/Fast Green staining, in sections of control esophagus (A), type 1 achalasia (B) and type 3 achalasia (C). The type 3 pattern was typically more aberrant than the other subtypes of achalasia. Arrows indicate regions of red staining (collagen) among the smooth muscle cells (intracellular regions, green). Scale bar, 50 µm. (D) Outcome of image analyses showing increased amount of ..read more
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Retrograde Cricopharyngeus Dysfunction, a New Motility Disorder: Single Center Case Series and Treatment Results
Journal of Neurogastroenterology and Motility
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2M ago
Retrograde cricopharyngeus dysfunction patient: gas reflux events (arrows) not triggering upper esophageal sphincter relaxation and followed by secondary peristalsis ..read more
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Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis
Journal of Neurogastroenterology and Motility
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2M ago
Mechanisms of gastrointestinal motility modulation in diabetic gastroparesis. The destruction and disappearance of interstitial cells of Cajal (ICC), abnormal levels of hormones in the gut-brain axis that affect gastric function and mitochondrial oxidative stress disorder leads to gastrointestinal dysfunction and produces gastroparesis. 5-HT, 5-hydroxytryptamine; CCK, cholecystokinin; SST, somatostatin; ROS, reactive oxygen species; SMCs, smooth muscle cells ..read more
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Interpretation of Impedance Data on High-resolution Impedance Manometry Studies—A Worldwide Survey
Journal of Neurogastroenterology and Motility
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5M ago
Participant’s work-up plan in cases of discrepancy between manometry and impedance data ..read more
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Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry
Journal of Neurogastroenterology and Motility
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5M ago
Effects of acute administration of codeine on the frequency of esophageal primary peristalsis. Codeine significantly increased the frequency of normal primary contraction was significantly higher after codeine treatment, and the frequencies of weak and failed contractions were significantly lower after codeine treatment compared with placebo treatment ..read more
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Refractory Gastroesophageal Reflux Disease: Diagnosis and Management
Journal of Neurogastroenterology and Motility
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5M ago
Management of refractory gastroesophageal reflux disease (GERD). Lifestyle adjustments are useful in any patient with reflux symptoms. Antisecretory therapy should be optimized and escalated if indicated. Adjunctive and topical agents, as well as adjunctive measures can be employed to improve symptoms. In patients with objective evidence of refractory GERD, escalation of management to anti-reflux surgery or other invasive interventions may be appropriate. H2RA, histamine H2 receptor antagonist; PPI, proton pump inhibitor; PCAB, potassium competitive acid blocker; G-POEM, gastric peroral endosc ..read more
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Regulatory T cells Are Increased and Correlate With Mast Cells in Eosinophilic Esophagitis
Journal of Neurogastroenterology and Motility
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5M ago
Infiltration of eosinophils, mast cells, T cells, and regulatory T cells (Tregs) in controls and patients with eosinophilic esophagitis (EoE) before and after treatment. (A-C) Hematoxylin and eosin (H&E) staining of biopsy sections. (D-F) CD117 staining of esophageal biopsy sections. (G-I) CD3 staining of esophageal biopsy sections. (J-L) Forkhead box P3 (FOXP3) staining of esophageal biopsy sections. Representative staining of controls (A, D, G, J), EoE patients before treatment (B, E, H, K), and EoE patients after treatment (C, F, I, L) are shown. Bar = 50 ..read more
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Symptomatic Response to Antibiotics in Patients With Small Intestinal Bacterial Overgrowth: A Systematic Review and Meta-analysis
Journal of Neurogastroenterology and Motility
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5M ago
Forrest plot of studies comparing the efficacy of antibiotics in irritable bowel syndrome (IBS) patients with or without small intestinal bacterial overgrowth (SIBO). The pooled response rate was 51.2% vs 23.4% in the SIBO and no SIBO group, respectively. Relative risk (95% CI) for improvement was 2.07 (1.40-3.08), = 0.0003. Heterogeneity was ..read more
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