Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: A nationwide study in a Western population
United European Gastroenterology Journal
by Steffi EM van de Ven, Janne M Falger, Rob HA Verhoeven, Robert J Baatenburg de Jong, Manon CW Spaander, Marco J Bruno, Arjun D Koch
1y ago
United European Gastroenterology Journal, Ahead of Print. BackgroundPatients with primary oesophageal squamous cell carcinoma are at risk of developing multiple primary tumours in the upper aero digestive tract. To date, most studies are performed in the Asian population. We aimed to evaluate the risk of multiple primary tumours in the upper aero digestive tract and stomach in patients with oesophageal squamous cell carcinoma in a Western population.MethodsWe performed a nationwide, retrospective cohort study in collaboration with the Netherlands Cancer Registry. Patients with primary oesophag ..read more
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Long-term outcomes of acute severe ulcerative colitis in the rescue therapy era: A multicentre cohort study
United European Gastroenterology Journal
by Stefano Festa, Maria L Scribano, Daniela Pugliese, Cristina Bezzio, Mariabeatrice Principi, Davide G Ribaldone, Mariangela Allocca, Giammarco Mocci, Giorgia Bodini, Rocco Spagnuolo, Piero Vernia, Silvia Mazzuoli, Francesco Costa, Brigida Barberio, Rocco Cosintino, Giulia Zerboni, Annalisa Aratari, Alessandro Armuzzi, Claudio Papi
1y ago
United European Gastroenterology Journal, Ahead of Print. BackgroundThe long-term course of ulcerative colitis after a severe attack is poorly understood. Second-line rescue therapy with cyclosporine or infliximab is effective for reducing short-term colectomy but the impact in the long-term is controversial.ObjectiveThe purpose of this study was to evaluate the long-term course of acute severe ulcerative colitis patients who avoid early colectomy either because of response to steroids or rescue therapy.MethodsThis was a multicentre retrospective cohort study of adult patients with acute sever ..read more
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Burnout in gastroenterology: Raise awareness and identify drivers
United European Gastroenterology Journal
by Elisabetta Buscarini, Krisztina B Gecse, Dina Tiniakos
1y ago
United European Gastroenterology Journal, Ahead of Print ..read more
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Management of pregnancy in women with cirrhosis
United European Gastroenterology Journal
by Mussarat N Rahim, Tasneem Pirani, Catherine Williamson, Michael A Heneghan
1y ago
United European Gastroenterology Journal, Ahead of Print. Although pregnancy is rare in women with cirrhosis, it is increasingly prevalent in an era of modern assisted conception techniques and improved awareness, monitoring and management of underlying liver disease. After overcoming the difficulties of subfertility and becoming pregnant, women undergo a ‘high-risk’ pregnancy which can be complicated by variceal haemorrhage (≤50%) and hepatic decompensation (≤25%). Management of these complications are similar to non-pregnant individuals. However, there are a few caveats to consider. These pr ..read more
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Metachronous neoplasms in patients with laterally spreading tumours during surveillance
United European Gastroenterology Journal
by Roel MM Bogie, Bjorn Winkens, Sean JJ Retra, Chantal MC le Clercq, Mariëlle W Bouwens, Eveline JA Rondagh, Li-Chun Chang, Rogier de Ridder, Chantal Hoge, Jan-Willem Straathof, Danny Goudkade, Silvia Sanduleanu-Dascalescu, Ad AM Masclee
1y ago
United European Gastroenterology Journal, Ahead of Print. BackgroundLaterally spreading tumours represent a major challenge for endoscopic detection and resection.ObjectiveTo examine synchronous and metachronous neoplasms in patients with laterally spreading tumours.MethodsWe prospectively collected colonoscopy and histopathology data from patients who underwent colonoscopy in our centre at up to 6 years’ follow-up. Post-resection surveillance outcomes between laterally spreading tumours, flat colorectal neoplasms 10 mm or greater, and large polypoid colorectal neoplasms, polypoid colorectal n ..read more
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Deprescribing medications that may increase the risk of hepatic encephalopathy: A qualitative study of patients with cirrhosis and their doctors
United European Gastroenterology Journal
by Sydni Williams, Jeremy Louissaint, Sam Nikirk, Jasmohan S Bajaj, Elliot B Tapper
1y ago
United European Gastroenterology Journal, Ahead of Print. Background and aimsMultiple medications are associated with an increased risk of incident hepatic encephalopathy. Despite this known risk, medications such as opioids, benzodiazepines, gabapentin/pregabalin, and/or proton pump inhibitors are increasingly prescribed to persons with cirrhosis. Deprescribing is a promising intervention to reduce the burden of hepatic encephalopathy. Given that deprescribing has not been trialed in cirrhosis, we evaluated the barriers and facilitators to safe and successful deprescribing in cirrhosis.Method ..read more
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Tumour–stroma ratio has poor prognostic value in non-pedunculated T1 colorectal cancer: A multi-centre case-cohort study
United European Gastroenterology Journal
by Hao Dang, Gabi W van Pelt, Krijn JC Haasnoot, Yara Backes, Sjoerd G Elias, Tom CJ Seerden, Matthijs P Schwartz, Bernhard WM Spanier, Wouter H de Vos tot Nederveen Cappel, Jeroen D van Bergeijk, Koen Kessels, Joost MJ Geesing, John N Groen, Frank ter Borg, Frank HJ Wolfhagen, Cornelis A Seldenrijk, Mihaela G Raicu, Anya N Milne, Anja UG van Lent, Lodewijk AA Brosens, G Johan A Offerhaus, Peter D Siersema, Rob AEM Tollenaar, James CH Hardwick, Lukas JAC Hawinkels, Leon MG Moons, Miangela M Lacle, Wilma E Mesker, Jurjen J Boonstra
1y ago
United European Gastroenterology Journal, Ahead of Print. BackgroundCurrent risk stratification models for early invasive (T1) colorectal cancer are not able to discriminate accurately between prognostic favourable and unfavourable tumours, resulting in over-treatment of a large (>80%) proportion of T1 colorectal cancer patients. The tumour–stroma ratio (TSR), which is a measure for the relative amount of desmoplastic tumour stroma, is reported to be a strong independent prognostic factor in advanced-stage colorectal cancer, with a high stromal content being associated with worse prognosis ..read more
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Single-capsule bismuth quadruple therapy: Preferable at the moment, but what should be next?
United European Gastroenterology Journal
by Hidekazu Suzuki, Hideki Mori
1y ago
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Factors influencing the outcome of vedolizumab treatment: Real-life data with objective outcome measurements
United European Gastroenterology Journal
by Orla Mader, Pascal Juillerat, Luc Biedermann, Pierre Michetti, Petr Hruz, Valerie Pittet, Gerhard Rogler, Nadine Zahnd-Straumann, Frank Seibold
1y ago
United European Gastroenterology Journal, Ahead of Print. BackgroundVedolizumab (VDZ), a humanized monoclonal antibody against α4β7-integrin, has shown efficacy in inflammatory bowel disease (IBD). It is of importance to assess the mid- to long-term efficacy of VDZ using real-life data.ObjectiveOur study aimed to determine the efficacy of VDZ in patients with IBD with and without prior exposure to anti-tumour necrosis factor (TNF) treatments in a real-life setting. Furthermore, we investigated confounding factors influencing the remission to VDZ.MethodsPatients participating in the Swiss IBD C ..read more
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European Registry on Helicobacter pylori Management: single-capsule bismuth quadruple therapy is effective in real-world clinical practice
United European Gastroenterology Journal
by Olga P Nyssen, Angeles Perez-Aisa, Manuel Castro-Fernandez, Rinaldo Pellicano, Jose M. Huguet, Luis Rodrigo, Juan Ortuño, Blas Jose Gomez-Rodriguez, Ricardo Marcos Pinto, Miguel Areia, Monica Perona, Oscar Nuñez, Marco Romano, Antonietta Gerarda Gravina, Liliana Pozzati, Miguel Fernandez-Bermejo, Marino Venerito, Peter Malfertheiner, Luis Fernanadez-Salazar, Antonio Gasbarrini, Dino Vaira, Ignasi Puig, Francis Megraud, Colm O’Morain, Javier P Gisbert
1y ago
United European Gastroenterology Journal, Ahead of Print. BackgroundThere has been resurgence in the use of bismuth quadruple therapy (proton pump inhibitor, bismuth, tetracycline and metronidazole) for treating Helicobacter pylori infection thanks to a three-in-one single-capsule formulation.ObjectiveTo evaluate the effectiveness and safety of the single-capsule bismuth quadruple therapy.MethodsData were collected in a multicentre, prospective registry of the clinical practice of gastroenterologists on the management of H. pylori infection, where patients were registered at the Asociación Esp ..read more
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