Comparison of biochemical, microbial and mucosal mRNA expression in bile acid diarrhoea and irritable bowel syndrome with diarrhoea
Gut
by Camilleri, M., Carlson, P., BouSaba, J., McKinzie, S., Vijayvargiya, P., Magnus, Y., Sannaa, W., Wang, X. J., Chedid, V., Zheng, T., Maselli, D., Atieh, J., Taylor, A., Nair, A. A., Kengunte Nagaraj, N., Johnson, S., Chen, J., Burton, D., Busciglio, I.
22h ago
Objective There are altered mucosal functions in irritable bowel syndrome with diarrhoea (IBS-D); ~30% of patients with IBS-D have abnormal bile acid (BA) metabolism (ABAM) and diarrhoea (summarised as BAD). Aim To compare biochemical parameters, gastrointestinal and colonic transit, rectal sensation and pathobiological mechanisms in IBS-D without ABAM and in BAD (serum 7C4>52 ng/mL). Design In patients with Rome III criteria of IBS-D, we compared biochemical features, colonic transit, rectal sensation, deep genotype of five BA-related genes, ileal and colonic mucosal mRNA (differential exp ..read more
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Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Gut
by Esteves, A. R., Munoz-Pinto, M. F., Nunes-Costa, D., Candeias, E., Silva, D. F., Magalhaes, J. D., Pereira-Santos, A. R., Ferreira, I. L., Alarico, S., Tiago, I., Empadinhas, N., Cardoso, S. M.
22h ago
Objective Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impact the brain. In this work, we sought to demonstrate that the effects of the microbial toxin β-N-methylamino-L-alanine (BMAA) in the gut may trigger some PD cases, which is especially worrying as this toxin is present in certain foods but not routinely monitored by public health authorities. Design To ..read more
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Undiagnosed inflammatory bowel disease among individuals undergoing colorectal cancer screening: a nationwide Danish cohort study 2014-2018
Gut
by Jess, T., Vestergaard, M. V., Iversen, A. T., Allin, K. H.
22h ago
Chiu et al recently investigated the long-term effectiveness of national faecal immunochemical test (FIT) screening for colorectal cancer (CRC).1 They demonstrated reduced risk of advanced-stage CRC and its mortality with larger reductions in distal CRC as compared with proximal CRC. An additional outcome of the CRC screening programme may be early detection of other diseases, such as inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). The prevalence of IBD is up to 1% in westernised countries.2 3 However, symptoms of IBD vary and may increase time to ..read more
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Letter to the editor: vaccination against upper respiratory infections is a matter of survival in alcoholic liver disease
Gut
by Itzel, T., Falconer, T., Daza, J., Roig, A., Park, J., Cheong, J. Y., Park, R. W., Wiest, I., Ebert, M., Hripcsak, G., Teufel, A.
22h ago
We read with great interest the report on SARS-CoV-2 infection in patients with primary biliary cholangitis (PBC) by Ampuero et al.1 An independent association of chronic liver disease with adverse clinical outcome in patients with COVID-19 was previously reported in this journal.2 However, the impact of SARS-CoV-2 and upper airway infections in general on patients with alcoholic liver disease (ALD) remains widely unknown. Yet, those data would be of high relevance to global public health and vaccination campaigns since alcohol related diseases are endemic. 57% of the population over age 15 ha ..read more
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Improved NGS variant calling tool for the PRSS1-PRSS2 locus
Gut
by Lou, H., Xie, B., Wang, Y., Gao, Y., Xu, S.
22h ago
With interest, we read the two recent studies by Weiss et al and Genin et al, who reported the false positive calls of the missense variants with next-generation sequencing (NGS) on the PRSS1–PRSS2 locus which is associated with pancreatitis.1 2 The false positives were due to the homology between the pseudo-genes PRSS3P2, TRY7 and the protein-coding genes PRSS1, PRSS2, which caused misaligned short-reads and confounded genetic diagnosis of pancreas disease. Here, to provide a cost-effective solution, we offered a toolkit named NGS.PRSS1-2caller (https://github.com/Shuhua-Group/NGS.PRSS1-2call ..read more
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Interleukin-11 drives human and mouse alcohol-related liver disease
Gut
by Effenberger, M., Widjaja, A. A., Grabherr, F., Schaefer, B., Grander, C., Mayr, L., Schwaerzler, J., Enrich, B., Moser, P., Fink, J., Pedrini, A., Jaschke, N., Kirchmair, A., Pfister, A., Hausmann, B., Bale, R., Putzer, D., Zoller, H., Schafer, S., Pjevac, P., Trajanoski, Z., Oberhuber, G., Adolph, T., Cook, S., Tilg, H.
22h ago
Objective Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease (ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic, proinflammatory cytokine with increasingly recognised toxicities in parenchymal and epithelial cells. We explored IL-11 serum levels and their prognostic value in patients suffering from AH and cirrhosis of various aetiology and experimental ALD. Design IL-11 serum concentration and tissue expression was determined in a cohort comprising 50 patients with AH, 110 patients with cirrhosis and 19 healthy volunteers. F ..read more
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Holistic healthcare in inflammatory bowel disease: time for patient-centric approaches?
Gut
by Sudhakar, P., Wellens, J., Verstockt, B., Ferrante, M., Sabino, J., Vermeire, S.
22h ago
Inflammatory bowel disease (IBD) is an emerging global disease characterised by chronic inflammation of the gastrointestinal tract. However, IBD is also manifested by several extraintestinal symptoms which, along with the intestinal symptoms, impact on the mental and emotional well-being of patients. Despite therapeutic advancements, only one-third of the diagnosed patients receiving approved medical treatments achieve short-term to medium-term remission. Consequently, patients who do not get successfully treated might resort to using complementary and alternative approaches to manage their sy ..read more
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Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells
Gut
by Alfarano, G., Audano, M., Di Chiaro, P., Balestrieri, C., Milan, M., Polletti, S., Spaggiari, P., Zerbi, A., Diaferia, G. R., Mitro, N., Natoli, G.
22h ago
Objective Pancreatic ductal adenocarcinomas (PDACs) include heterogeneous mixtures of low-grade cells forming pseudoglandular structures and compact nests of high-grade cells organised in non-glandular patterns. We previously reported that low-grade PDAC cells display high expression of interferon regulatory factor 1 (IRF1), a pivotal transcription factor of the interferon (IFN) system, suggesting grade-specific, cell-intrinsic activation of IFN responses. Here, we set out to determine the molecular bases and the functional impact of the activation of IFN-regulated responses in human PDACs. De ..read more
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Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database
Gut
by Vitale, A., Svegliati-Baroni, G., Ortolani, A., Cucco, M., Dalla Riva, G. V., Giannini, E. G., Piscaglia, F., Rapaccini, G., Di Marco, M., Caturelli, E., Zoli, M., Sacco, R., Cabibbo, G., Marra, F., Mega, A., Morisco, F., Gasbarrini, A., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Oliveri, F., Pelizzaro, F., Ramirez Morales, R., Cillo, U., Trevisani, F., Miele, L., Marchesini, G., Farinati, F., for the Italian Liver Cancer (ITA.LI.CA) group, Sartori, Imondi, Penzo, Biselli, Caraceni, Garuti, Gramenzi, Neri, Ramboldi, Santi, Granito, Muratori, Piscaglia, Sansone, Tovoli, Dajti, Marasco, Ravaioli, Cappelli, Golfieri, Mosconi, Renzulli, Cela, Facciorusso, Cacciato, Casagrande, Moscatelli, Pellegatta, Matthaeis, Allegrini, Lauria, Ghittoni, Pelecca, Chegai, Coratella, Ortenzi, Biasini, Olivani, Inno, Marchetti, Busacca, Cabibbo, Camma, Martino, Maria Rizzo, Franze, Saitta, Sauchella, Bevilacqua, Berardinelli, Borghi, Gardini, Conti, Cucchetti, DallAglio, Ercolani, Campani, Bonaventura, Gitto, Antonio Malerba, Capasso, Guarino, Oliveri, Romagnoli, Di Bucchianico
22h ago
Background Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a new inclusive definition of the whole spectrum of liver diseases associated to metabolic disorders. The main objective of this study was to compare patients with MAFLD and non-MAFLD with hepatocellular carcinoma (HCC) included in a nationally representative cohort. Methods We analysed 6882 consecutive patients with HCC enrolled from 2002 to 2019 by 23 Italian Liver Cancer centres to compare epidemiological and future trends in three subgroups: pure, single aetiology MAFLD (S-MAFLD); mixed aetiology MAFLD (meta ..read more
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Correction: O36 Prevalence of repeat FIT testing in symptomatic patients attending primary care
Gut
by
22h ago
Johnstone M, Digby J, Strachan J, et al. O36 Prevalence of repeat FIT testing in symptomatic patients attending primary care. Gut 2022;71:A22. The author, Yassir Al-Azzawi, was missed from this abstract ..read more
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