Acute pancreatitis after nitrous oxide abuse: A case report
JGH Open
by Shanshan Chen, Linjie Guo, Yufang Wang
5d ago
We report a young and previously healthy female who was first admitted to the gastroenterological department with acute pancreatitis and was finally diagnosed with N2O intoxication. Thus, we found that acute pancreatitis may be a rare complication in N2O intoxication. Abstract The recreational use of nitrous oxide (N2O) is sharply increasing among young adults. N2O abuse can cause serious complications. However, the association between acute pancreatitis and N2O is rarely reported. Here we report a case of a young and previously healthy female with widespread cutaneous lesions, neurologic sy ..read more
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Real‐world impact of a subsidy decision of sofosbuvir–velpatasvir for treatment of chronic hepatitis C on clinical practice and patient outcomes
JGH Open
by Chee‐Kiat Tan, Xue‐Shi Luo, Benjamin Shao‐Kiat Ong, Liang Lin, Kwong‐Hoe Ng
1w ago
Sofosbuvir–velpatasvir was recommended for subsidy to treat chronic hepatitis C in Singapore in 2018, following which utilization trends and prescribing patterns were assessed using aggregated drug utilization data from public hospitals' dispensing systems and clinical data from the national electronic health record database. This study reports the impact of the subsidy decision on clinical practice and the clinical effectiveness of sofosbuvir–velpatasvir in a real-world setting. The subsidy decision led to increased accessibility to patients and intended changes in clinical practice, and sof ..read more
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Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer
JGH Open
by Menazir Sha, Basir Kunduzi, Saied Froghi, Alberto Quaglia, Brian Davidson, Giuseppe K Fusai
1w ago
This systematic review aims to evaluate the current literature involving pancreatic cancer patient groups in search of highly accurate exosomal biomarkers. We reviewed 9 studies which involved 565 participants (331 PC and 234 controls). The mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, and ODC1) and GPC1 reported the highest performing sensitivity and specificity at 100% each. Abstract Background and Aim New biomarkers have the potential to facilitate early diagnosis of pancreatic cancer (PC). Circulating exosomes are cell-derived protein complexes containing RNA that can be used ..read more
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Common bile duct stone‐related parameters and their potential prognostic values for stone extraction requiring endoscopic papillary large balloon dilation
JGH Open
by Chote Wongkanong, Jayanton Patumanond, Thawee Ratanachu‐ek, Sunhawit Junrungsee, Apichat Tantraworasin
1w ago
Endoscopic CBD stone removal is more difficult with stones larger than 2 mm than with distal CBD diameter or round or square-shaped stones. Therefore, endoscopic large papillary balloon dilatation (ELPBD) is probably more required for stones larger than 2 mm than for distal CBD; likewise, round or square-shaped stones are likely more required for ELPBD than other shapes. Abstract Background and Aim For difficult common bile duct (CBD) stones, endoscopic sphincterotomy accompanied by endoscopic papillary large balloon dilatation (EPLBD) may be the preferred initial procedure according to the ..read more
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Management of Helicobacter pylori infection
JGH Open
by Natsuda Aumpan, Varocha Mahachai, Ratha‐korn Vilaichone
2w ago
Antibiotic-resistant H. pylori strains have been increasing in most regions. Recommended first-line regimens for H. pylori eradication are classified according to clarithromycin resistance. For patients with multiple treatment failure, antimicrobial susceptibility testing (AST) should be performed. Abstract Helicobacter pylori infection exhibits a wide disease spectrum ranging from asymptomatic gastritis, peptic ulcer disease, to gastric cancer. H. pylori can induce dysbiosis of gastric microbiota in the pathway of carcinogenesis and successful eradication can restore gastric homeostasis. Di ..read more
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Treatment outcomes and costs of a simplified antiretroviral treatment strategy for hepatitis C among Hepatitis C Virus and Human Immuno deficiency Virus co‐infected patients in Ukraine
JGH Open
by Sergie Antoniak, Charles S Chasela, Morgan Julie Freiman, Yulia Stopolianska, Tetiana Barnard, Malini M Gandhi, Maria Liulchuk, Zhanna Tsenilova, Tretiakov Viktor, Jeri Dible, Constance Wose Kinge, Francis Akpan, Thomas Minior, Ntombi Sigwebela, Sofiane Mohamed, Matthiue Barralon, Fadzai Marange, Clint Cavenaugh, Charles Vander Horst, Svitlana Antonyak, Thembisile Xulu, Kara W Chew, Ian Sanne, Sydney Rosen, for EQUIP Health
2w ago
We assessed treatment and cost outcomes for integrated HIV and viral hepatitis testing with ledipasvir/sofosbuvir ± weight-based ribavirin for 12 weeks in Kyiv, Ukraine. Overall, a sustained virological response (SVR) was achieved in 831 of 868 patients (95.7%). The SVR in patients with hepatitis C alone and hepatitis C/HIV co-infection was 98.4% and 93.6%, respectively. Using generic medication, costs per patient 44 were estimated at US$680. Abstract Background and Aim To demonstrate the use of a standard dose of ledipasvir (LDV) and sofosbuvir (SOF), with or without ribavirin, to treat hep ..read more
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A rare cause of jejunal perforation: Monomorphic epitheliotropic intestinal T‐cell lymphoma
JGH Open
by Masahiro Yanagi, Takuya Komura, Takashi Kagaya
3w ago
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a very rare intestinal T-cell lymphoma which is observed most frequently in the jejunum. MEITL is prone to cause intestinal perforation and the prognosis is very poor when it occurs. Here we report a fatal case of MEITL causing jejunal perforation at the time of diagnosis in a 79-year-old man. Abstract Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a very rare intestinal T-cell lymphoma which is observed most frequently in the jejunum. MEITL is prone to cause intestinal perforation and the prognosis is very ..read more
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Obliterative portal venopathy: A neglected and probably misdiagnosed disease with peculiar etiology in South America
JGH Open
by Vinícius Nunes, Luiz A R Freitas, Juliana R Freitas, Caio Araújo, Gildásio N Junior, Maria I Schinoni, Fernando Bessone, Raymundo Paraná
3w ago
Classically described in the group of non-cirrhotic portal hypertension, obliterative portal venopathy (OPV) causes are still unknown. Our aim is to describe the characteristics of 43 OPV patients and potential risk factors. Clinically significant portal hypertension was found in 28% of cases. The most frequent indication for liver biopsy was elevation of liver enzymes, mostly γ-glutamyl transferase increase in 76% of patients. One third of our patients have exposure to medications, especially herbal medicines at the time of enzymatic changes. Abstract Background and Aim Obliterative portal ..read more
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Issue Information
JGH Open
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3w ago
JGH Open, Volume 6, Issue 11, Page 733-734, November 2022 ..read more
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Helicobacter pylori: Have potential benefits been overlooked?
JGH Open
by Jonathon P Schubert, Christopher K Rayner, Samuel P Costello, Ian C Roberts‐Thomson, Samuel C Forster, Robert V Bryant
3w ago
JGH Open, Volume 6, Issue 11, Page 735-737, November 2022 ..read more
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