Usefulness of health checkup‐based indices in identifying metabolic dysfunction‐associated steatotic liver disease
JGH Open
by Takao Miwa, Satoko Tajirika, Nanako Imamura, Miho Adachi, Ryo Horita, Tatsunori Hanai, Cheng Han Ng, Mohammad Shadab Siddiqui, Taku Fukao, Masahito Shimizu, Mayumi Yamamoto
1d ago
The “Nara declaration” recommends further investigations to evaluate chronic liver disease in individuals with serum alanine aminotransferase (ALT) levels > 30 IU/L. Our study evaluated the validity of the Nara declaration suggesting the use of serum ALT > 30 IU/L to identify metabolic dysfunction-associated steatotic liver disease (MASLD) and further provided valuable evidence to validate the ability of fatty liver index and hepatic steatosis index to act as indices in identifying MASLD during health checkups. Abstract Aims The application of indices in the context of metabolic dysfun ..read more
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Clinical practice and outcome of patients with elderly‐onset ulcerative colitis: Insights from a nationwide claims database study in Japan
JGH Open
by Rintaro Moroi, Yoichi Kakuta, Hiroshi Nagai, Yusuke Shimoyama, Takeo Naito, Hisashi Shiga, Yoshitaka Kinouchi, Atsushi Masamune
1d ago
The severity and clinical course between the elderly onset and non-elderly onset Ulcerative colitis groups may not differ in the long term after onset of ulcerative colitis. Abstract Background and Aim The number of older patients with ulcerative colitis is increasing; however, limited data exist regarding the differences between elderly- and non-elderly-onset ulcerative colitis. We aimed to compare the clinical practice and course of elderly-onset ulcerative colitis with those of non-elderly-onset ulcerative colitis. Methods We selected older patients with ulcerative colitis and divided the ..read more
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Clinical performance of fecal calprotectin, lactoferrin, and hemoglobin for evaluating the disease activity of IBD and detecting colorectal tumors
JGH Open
by Tsukasa Yamakawa, Takakazu Miyake, Yoshihiro Yokoyama, Tomoe Kazama, Yuki Hayashi, Daisuke Hirayama, Shinji Yoshii, Hiro‐o Yamano, Satoshi Takahashi, Hiroshi Nakase
2w ago
This study presented that fecal biomarkers, calprotectin (Cp) and lactoferrin (Lf), can be almost equivalent biomarkers to assess the clinical activity in patients with UC. Moreover, fecal Cp and Lf levels are also elevated in patients with colorectal tumors, although fecal hemoglobin is the most useful marker for detecting colorectal cancer, adding fecal Cp and Lf may compensate for the low sensitivity of screening for colorectal tumors based on hemoglobin alone. Abstract Background and Aim Recently, noninvasive fecal markers have been used as indicators of intestinal inflammation in patien ..read more
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Arterial structure and function in children with inflammatory bowel disease
JGH Open
by Asha Jois, Diana Zannino, Anthony G Catto‐Smith, Meg Kaegi, Jonathan P Mynard, Jeremy Rosenbaum, Mark Oliver, Winita Hardikar, George Alex, David Burgner
2w ago
As adults with inflammatory bowel disease (IBD) have an increased risk of cardiovascular disease, we sought to determine whether children with IBD might have early adverse changes in arterial structure function as a measure of increased cardiovascular risk. This case–control study found that after a mean disease duration of 2.49 years, children with IBD did not have a statistically significant increased risk of having abnormal measures of arterial structure and function. Abstract Background and Aim People with inflammatory bowel disease (IBD) have an increased risk of cardiovascular disease ..read more
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From pill to pain: Alendronate‐induced esophageal injury—A case report and review
JGH Open
by Zhen Fan, Hayat Khizar, Jinjiao Lu, Anhua Wang, Tong Xun, Xiao Zhang, Hongfeng Zhao
2w ago
This case report is a timely reminder of the importance of thorough pharmacovigilance, patient education, and smart therapeutic decision-making in the context of alendronate use. To properly treat and prevent problems with the esophagus caused by alendronate, additional research is required. Abstract Background Alendronate is used to treat Paget's bone disease, glucocorticoid-induced osteoporosis, and postmenopausal osteoporosis because it suppresses osteoclast activity to stop bone resorption. Case report We present an exceptional case of esophagitis caused by alendronate. Blood tests and o ..read more
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Proton pump inhibitor versus potassium‐competitive acid blocker in gastroesophageal reflux disease
JGH Open
by Tadayuki Oshima
2w ago
JGH Open, Volume 8, Issue 6, June 2024 ..read more
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2w ago
JGH Open, Volume 8, Issue 6, June 2024 ..read more
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Correction to “Diffuse large B‐cell lymphoma in large intestine presenting as multiple polypoid lesions”
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3w ago
JGH Open, Volume 8, Issue 5, May 2024 ..read more
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Dietary characteristics associated with the risk of non‐alcoholic fatty liver disease and metabolic dysfunction‐associated steatotic liver disease in non‐obese Japanese participants: A cross‐sectional study
JGH Open
by Hirokazu Taniguchi, Miho Ueda, Fumika Sano, Yukiko Kobayashi, Takatomo Shima
3w ago
Some dietary characteristics are associated with the prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) in non-obese participants.The findings suggest the importance of healthy dietary choices to prevent non-obese steatotic liver disease. Furthermore, the dietary characteristics are not identical between men and women. The results suggest that it is necessary to pay attention to sex differences in dietary characteristics to prevent non-obese steatotic liver disease. Abstract Background and Aim Dietary characteristics a ..read more
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Evolution, adaptation, and new applications of the FODMAP diet
JGH Open
by Leigh O'Brien, Arezina Kasti, Emma P. Halmos, Caroline Tuck, Jane Varney
1M ago
This paper summarizes the evolution of the FODMAP diet, and explores some of the newer applications and adaptations of this diet therapy, including a proposed five-phase FODMAP diet framework. Abstract The FODMAP diet has been a treatment of irritable bowel syndrome (IBS) for many years. Rigorous scientific evaluation and clinical application of the FODMAP diet have generated deep understanding regarding clinical efficacy, mechanisms of action, and potential adverse effects of this dietary approach. In turn, this knowledge has allowed fine-tuning of the diet to optimize treatment benefits an ..read more
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