Blue and Green Lines: The ROC curve of EUS, area ratio in predicting M/SM of type 0–II gastric gastric cancer. Yellow line: The ROC curve of DPS in predicting SM1/SM2 of type 0–II gastric gastric cancer. The area ratio has the highest diagnostic accuracy (91.6%). Abstract Background and Aim The microsurface structure reflects the degree of damage to the glands, which is related to the invasion depth of early gastric cancer. To evaluate the diagnostic value of quantitative microsurface structure analysis for estimating the invasion depth of early gastric cancer. Methods White-light imaging an ..read more

A retrospective study was conducted in patients with inflammatory bowel disease, to investigate the utility of C-reactive protein-to-albumin ratio (CAR) in disease activity monitoring (measured by faecal calprotectin or Mayo Endoscopic Score) and in predicting infliximab trough levels. CAR was only a modest discriminator of subtherapeutic infliximab trough levels and offered little more than C-reactive protein alone in detecting objective active inflammation. Abstract Background and Aim C-reactive protein (CRP)-to-albumin ratio (CAR) is a novel score with prognostic value in inflammatory con ..read more

From 1999 to 2020, gastrointestinal cancer-related mortality in the United States generally declined, with the age-adjusted mortality rate decreasing from 46.7 to 38.4 per 100,000. Despite this overall reduction, disparities persist with varying rates of decline among different racial groups and increases in mortality for cancers of the small bowel, anus, pancreas, and liver. Significant declines were noted in esophageal, stomach, colon, rectal, and gallbladder cancers, highlighting variations by sex and race. Abstract Background and Aim This study investigates temporal trends in gastrointes ..read more

While supportive measures, intravenous insulin, and plasmapheresis are possible treatment modalities for hypertriglyceridemia-induced acute pancreatitis (HGT-AP), definitive guidelines evaluating the best therapeutic approach are not clearly established. We report a 42-year-old male who was found to have HGT-AP and developed necrotizing pancreatitis and subsequent multi-organ failure despite early initiation of intravenous insulin and plasmapheresis. Future studies are warranted to assess risk factors associated with outcomes of HTG-AP, and to evaluate the role of plasmapheresis in HTG-AP and ..read more

This study demonstrated that 48-week pemafibrate administration improved liver-related enzymes and surrogate marker of liver fibrosis in patients with MASLD. Abstract Background and Aim This study aimed to clarify the efficacy and safety of 48-week pemafibrate treatment in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) complicated by dyslipidemia. Methods A total of 110 patients diagnosed with MASLD complicated by dyslipidemia received pemafibrate at a dose of 0.1 mg twice daily for 48 weeks. Results The participants were 54 males and 37 females, with a median ..read more

Abstract Background and Aim Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. However, the evidence of etrolizumab efficacy and safety in ulcerative colitis remains inconclusive. Therefore, we aim to evaluate the safety and efficacy of etrolizumab as an induction and maintenance therapy for active moderate to severe ulcerative colitis. Methods We synthesized randomized controlled studies (RCTs) from MEDLINE, Scopus, EMBASE, PubMed, Web of Science, and Cochrane Library until April 2023. The risk ratio (RR) for dichotomous outcomes with the corresponding 95% confidence interval ..read more

This randomised controlled study compared neoplasia eradication using hot avulsion and argon plasma coagulation in colonic polyps when snare polypectomy had failed. The residual adenoma rate at 6 months (hot avulsion 6% vs argon plasma coagulation 21% p = 0.09) and 18 months was not different (6.6 % vs 3.6% p = .25). One patient in the argon plasma coagulation arm was diagnosed with metastatic cancer of likely colorectal origin despite benign histology in the original polypectomy specimen, supporting the importance of tissue acquisition. Abstract Background and Aim Snare resection of nonlift ..read more

In comparison to lansoprazole 15 mg, vonoprazan 10 mg and 20 mg resulted in significantly higher maintenance of healed erosive esophagitis. Any treatment-emergent adverse events were greater with vonoprazan 20 mg compared to lansoprazole 15 mg but not vonoprazan 10 mg. Abstract Introduction Proton pump inhibitor (PPI) is the mainstay therapy for the maintenance of healed erosive esophagitis (EE). It is unknown whether potassium-competitive acid blockers (PCABs) are more efficacious and safer than PPIs. Methods Only randomized controlled trials (RCTs) comparing PCABs to PPIs in the maintenanc ..read more

This study evaluates the efficacy of antimicrobial therapy durations recommended by the Tokyo Guidelines 2018 for acute cholangitis (AC), comparing different obstruction etiologies. Results indicate that patients with multiple hilar biliary obstructions (Group 3) experience poorer outcomes compared to those with single obstructions (Groups 1 and 2), suggesting that treatment efficacy is influenced by obstruction complexity, irrespective of the antimicrobial therapy duration. Abstract Background and Aim The appropriate duration of antimicrobial therapy for acute cholangitis (AC) arising from ..read more

This randomized, placebo-controlled study investigated the addition of pinaverium bromide to omeprazole for treating refractory functional dyspepsia (FD). Results showed no significant difference between pinaverium bromide and placebo in terms of achieving adequate symptom relief, overall symptom scores, or quality of life improvements. While pinaverium bromide was well-tolerated, the study suggests it provides no additional benefit for managing refractory FD when combined with omeprazole. Abstract Background and Aim Functional dyspepsia (FD) remains a therapeutic challenge, and the efficacy ..read more