Systematic review of machine learning models in predicting the risk of bleed/grade of esophageal varices in patients with liver cirrhosis: A comprehensive methodological analysis
Journal of Gastroenterology and Hepatology
by Sheza Malik, Bettina Gabrielle Tenorio, Vishali Moond, Dushyant Singh Dahiya, Ravi Vora, Nader Dbouk
2d ago
Abstract Esophageal varices (EV) in liver cirrhosis carry high mortality risks. Traditional endoscopy, which is costly and subjective, prompts a shift towards machine learning (ML). This review critically evaluates ML applications in predicting bleeding risks and grading EV in patients with liver cirrhosis. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we conducted a systematic review of studies using ML to predict the risk of variceal bleeding and/or grade EV in liver disease patients. Data extraction and bias assessment followed the CHA ..read more
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Meta‐analysis and trial sequential analysis of randomized controlled trials comparing aggressive versus non‐aggressive intravenous fluid therapy in acute pancreatitis: an insight into the existence of type 2 error
Journal of Gastroenterology and Hepatology
by Daisy Evans, Shahin Hajibandeh, Shahab Hajibandeh, Tejinderjit S Athwal, Thomas Satyadas
6d ago
Abstract Background and Aim We aimed to evaluate comparative outcomes of aggressive versus non-aggressive intravenous fluid (IVF) therapy in patients with acute pancreatitis. Methods A systematic search of electronic data sources and bibliographic reference lists were conducted. All randomized controlled trials (RCTs) reporting outcomes of aggressive versus non-aggressive IVF therapy in acute pancreatitis were included and their risk of bias were assessed. Effect sizes were determined for overall mortality, systemic inflammatory response syndrome (SIRS), sepsis, respiratory failure, pancreatic ..read more
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Colorectal adenoma detection rate using texture and color enhancement imaging versus white light imaging with chromoendoscopy: a propensity score matching study
Journal of Gastroenterology and Hepatology
by Osamu Toyoshima, Toshihiro Nishizawa, Takuma Hiramatsu, Tatsuya Matsuno, Shuntaro Yoshida, Hiroya Mizutani, Hirotoshi Ebinuma, Takahisa Matsuda, Yutaka Saito, Mitsuhiro Fujishiro
6d ago
Abstract Background and Aim Few studies have evaluated the adenoma detection rate (ADR) of colonoscopy with texture and color enhancement imaging (TXI), a novel image-enhancing technology. This study compares the detection of colorectal polyps using TXI to that using white light imaging (WLI). Methods This single-center retrospective study used propensity-matched scoring based on the patients' baseline characteristics (age, sex, indication, bowel preparation, endoscopist, colonoscope type, and withdrawal time) to compare the results of patients who underwent chromoendoscopy using WLI or TXI a ..read more
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Revisiting the steatosis‐associated fibrosis estimator score in young Asian subjects with steatotic liver disease and consideration for population variability
Journal of Gastroenterology and Hepatology
by Jiwon Yang, Won‐Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young‐Suk Lim, Han Chu Lee, Jonggi Choi
6d ago
Abstract Background and Aim The steatosis-associated fibrosis estimator (SAFE) score has been developed to distinguish clinically significant fibrosis in patients with steatotic liver disease (SLD). However, validation of its performance in Asian subjects is limited. This study aimed to evaluate the performance of the SAFE score in Asian subjects with biopsy-proven SLD and in different subgroups according to age, sex, and body mass index. Methods We retrospectively analyzed 6383 living liver donors who underwent a liver biopsy between 2005 and 2023. Of these, 1551 subjects with biopsy-proven ..read more
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Gastrointestinal: A case of ulcerative colitis complicated by Tolosa‐hunt syndrome and pyoderma gangrenosum and featuring rare extraintestinal manifestations
Journal of Gastroenterology and Hepatology
by M Katsurahara, M Nakamura, Y Hamada, K Tanaka, N Horiki, H Nakagawa
6d ago
Journal of Gastroenterology and Hepatology, EarlyView ..read more
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Idiopathic myointimal hyperplasia of the mesenteric veins could be related to mesenteric arteriovenous malformation
Journal of Gastroenterology and Hepatology
by D Huynh, P Hendy, M Mortimore
1w ago
Journal of Gastroenterology and Hepatology, EarlyView ..read more
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Analysis of autoimmune hepatitis with acute presentation in the early stage of illness
Journal of Gastroenterology and Hepatology
by Keiichi Fujiwara, Yoshihiro Fukuda, Masahiko Sanada, Shuko Koizumi, Katsushi Seza, Masaya Saito, Osamu Yokosuka, Naoya Kato
1w ago
Abstract Background and Aim There is no gold standard for making the diagnosis of autoimmune hepatitis (AIH), and the diagnosis of acute onset AIH (A-AIH) is most challenging. A-AIH sometimes develops into acute liver failure with poor prognosis if the diagnosis is delayed. Therefore, it is most important for the better prognosis to diagnose non-severe A-AIH early and treat appropriately. However, features in the early stage of A-AIH are unclear. We examined initial characteristics of non-severe A-AIH in detail and tried to find novel clinical features for the early diagnosis. Methods Clinica ..read more
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Prevalence of functional esophageal disorders and associated clinical characteristics in patients with proton‐pump‐inhibitor‐unresponsive reflux symptoms
Journal of Gastroenterology and Hepatology
by Ming‐Han Wei, Chien‐Chuan Chen, Hui‐Chuan Lee, Yi‐Chia Lee, Hsiu‐Po Wang, Ming‐Shiang Wu, Jia‐Feng Wu, Ping‐Huei Tseng
1w ago
Abstract Background and Aim Patients with proton-pump-inhibitor (PPI)-unresponsive reflux symptoms, often caused by functional esophageal disorders (FED), are frequently encountered in clinical practice. We aimed to investigate the prevalence of FED and its associated clinical characteristics in patients with PPI-unresponsive reflux symptoms. Methods We retrospectively identified patients who were evaluated for persistent typical reflux symptoms, despite ≥8 weeks of PPI treatment, at the National Taiwan University Hospital from 2014 to 2023. All patients underwent a comprehensive evaluat ..read more
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Potential role of stem cells from human exfoliated deciduous teeth in inducing liver regeneration
Journal of Gastroenterology and Hepatology
by Fatima Safira Alatas, Takayoshi Yamaza, Toshiharu Matsuura, Lukito Ongko, Muzal Kadim, Shouichi Ohga, Tomoaki Taguchi, Tatsuro Tajiri
1w ago
Abstract Background and Aim Even with advancement of medical technologies, liver transplantation still faces several major challenges. Hence, other treatment modalities are urgently needed for patients with end-stage liver disease. Stem cells from human exfoliated deciduous teeth (SHED) was discovered to have highly proliferative and pluripotent properties; including differentiation into hepatocyte-like cells. This study aims to investigate the capability of intrasplenic transplanted SHED and SHED-Hep cells in inducing proliferation of stem cells and native hepatocytes in order to accelerate ..read more
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Gastrointestinal involvement in neuromuscular disorders
Journal of Gastroenterology and Hepatology
by Josef Finsterer, Walter Strobl
1w ago
Abstract Although not often discussed, many of the neuromuscular disorders (NMDs) affect the gastrointestinal tract (GIT). Depending on the type of NMD, the prevalence of GIT involvement ranges from <5% (e.g. hereditary neuropathies, myofibrillar myopathies) to 100% (e.g. MNGIE, OPMD). Particularly in NMDs with multisystem affection, involvement of the GIT can dominate the clinical presentation or at least make up a significant part of the clinical picture. The most prominent representatives of NMDs with multisystem involvement are the mitochondrial disorders (MIDs) and the myotonic dystrop ..read more
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