Genome Medicine
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Genome Medicine is an open-access journal publishing outstanding research in the application of genetics, genomics, and multi-omics to understand, diagnose and treat disease, bridging the basic science and clinical research communities. Our publication policy combines selection for broad interest and importance with a commitment to serving authors well.
Genome Medicine
1d ago
Infections caused by multidrug-resistant gram-negative bacteria present a severe threat to global public health. The WHO defines drug-resistant Klebsiella pneumoniae as a priority pathogen for which alternative t ..read more
Genome Medicine
1w ago
Using computational tools, bulk transcriptomics can be deconvoluted to estimate the abundance of constituent cell types. However, existing deconvolution methods are conditioned on the assumption that the whole ..read more
Genome Medicine
1w ago
The clinical utility of genetic information for type 2 diabetes (T2D) prediction with polygenic scores (PGS) in ancestrally diverse, real-world US healthcare systems is unclear, especially for those at low cli ..read more
Genome Medicine
1w ago
Genetic variants that severely alter protein products (e.g. nonsense, frameshift) are often associated with disease. For some genes, these predicted loss-of-function variants (pLoFs) are observed throughout th ..read more
Genome Medicine
2w ago
Implementation of clinical metagenomics and pathogen genomic surveillance can be particularly challenging due to the lack of bioinformatics tools and/or expertise. In order to face this challenge, we have prev ..read more
Genome Medicine
2w ago
The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a new kernel ..read more
Genome Medicine
2w ago
Gut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory responses in diabetes, particularly in the context of HIV infection, remains unclear ..read more
Genome Medicine
2w ago
Klebsiella pneumoniae is a major bacterial and opportunistic human pathogen, increasingly recognized as a healthcare burden globally. The convergence of resistance and virulence in K. pneumoniae strains has led t ..read more
PheSeq, a Bayesian deep learning model to enhance and interpret the gene-disease association studies
Genome Medicine
3w ago
Despite the abundance of genotype-phenotype association studies, the resulting association outcomes often lack robustness and interpretations. To address these challenges, we introduce PheSeq, a Bayesian deep ..read more
Genome Medicine
3w ago
Carbapenem-resistant Escherichia coli (CREC) has been considered as WHO priority pathogens, causing a great public health concern globally. While CREC from patients has been thoroughly investigated, the prevalenc ..read more