Genome Medicine
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Genome Medicine is an open-access journal publishing outstanding research in the application of genetics, genomics, and multi-omics to understand, diagnose and treat disease, bridging the basic science and clinical research communities. Our publication policy combines selection for broad interest and importance with a commitment to serving authors well.
Genome Medicine
4d ago
Gut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory responses in diabetes, particularly in the context of HIV infection, remains unclear ..read more
Genome Medicine
4d ago
Klebsiella pneumoniae is a major bacterial and opportunistic human pathogen, increasingly recognized as a healthcare burden globally. The convergence of resistance and virulence in K. pneumoniae strains has led t ..read more
PheSeq, a Bayesian deep learning model to enhance and interpret the gene-disease association studies
Genome Medicine
1w ago
Despite the abundance of genotype-phenotype association studies, the resulting association outcomes often lack robustness and interpretations. To address these challenges, we introduce PheSeq, a Bayesian deep ..read more
Genome Medicine
1w ago
Carbapenem-resistant Escherichia coli (CREC) has been considered as WHO priority pathogens, causing a great public health concern globally. While CREC from patients has been thoroughly investigated, the prevalenc ..read more
Genome Medicine
1w ago
Most primary Triple Negative Breast Cancers (TNBCs) show amplification of the Epidermal Growth Factor Receptor (EGFR) gene, leading to increased protein expression. However, unlike other EGFR-driven cancers, t ..read more
Genome Medicine
2w ago
Genome sequencing of large biobanks from under-represented ancestries provides a valuable resource for the interrogation of Mendelian disease burden at world population level, complementing small-scale familia ..read more
Genome Medicine
2w ago
Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connection to modifiable lifestyle risk in the form of tobacco smoke has long been establishe ..read more
Genome Medicine
3w ago
NODAL signaling plays a critical role in embryonic patterning and heart development in vertebrates. Genetic variants resulting in perturbations of the TGF-β/NODAL signaling pathway have reproducibly been shown ..read more
Genome Medicine
1M ago
Histopathology and genomic profiling are cornerstones of precision oncology and are routinely obtained for patients with cancer. Traditionally, histopathology slides are manually reviewed by highly trained pat ..read more
Genome Medicine
1M ago
Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting ..read more