Palm-based tocotrienol-rich fraction (TRF) supplementation modulates cardiac sod1 expression, fxr target gene expression, and tauro-conjugated bile acid levels in aleptinemic mice fed a high-fat diet
BioMed Central » Genes & Nutrition
by Nur Aliah Natasha Md Shahrulnizam, Mohd Danial Mohd Efendy Goon, Sharaniza Ab Rahim, Sook Weih Lew, Siti Hamimah Sheikh Abdul Kadir and Effendi Ibrahim
15h ago
Tocotrienol-rich fraction (TRF) has been reported to protect the heart from oxidative stress-induced inflammation. It is, however, unclear whether the protective effects of TRF against oxidative stress involve ..read more
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Genome-wide association study of serum magnesium in type 2 diabetes
BioMed Central » Genes & Nutrition
by Lynette J. Oost, Roderick C. Slieker, Marieke T. Blom, Leen M. ’t Hart, Joost G. J. Hoenderop, Joline W. J. Beulens and Jeroen H. F. de Baaij
1M ago
People with type 2 diabetes have a tenfold higher prevalence of hypomagnesemia, which is suggested to be caused by low dietary magnesium intake, medication use, and genetics. This study aims to identify the ge ..read more
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Dysfunction of DMT1 and miR-135b in the gut-testis axis in high-fat diet male mice
BioMed Central » Genes & Nutrition
by Yanru Zhang, Ruike Ding, Yulin Zhang, Jia Qi, Wenbin Cao, Lijun Deng, Lin Zhou, Yun Ye, Ying Xue and Enqi Liu
1M ago
Obese patients have been found to be susceptible to iron deficiency, and malabsorption of dietary iron is the cause of obesity-related iron deficiency (ORID). Divalent metal transporter 1 (DMT1) and ferroporti ..read more
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From common to rare: repurposing of bempedoic acid for the treatment of glycogen storage disease type 1
BioMed Central » Genes & Nutrition
by Anibh M. Das
5M ago
Hypoketotic hypoglycaemia is a biochemical hallmark of glycogen storage disease type 1 (GSD1). This is due to inhibition of carnitine-palmitoyl transferase 1 by malonyl-CoA. This inhibits the influx of long-ch ..read more
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Causal associations of 25-hydroxyvitamin D with functional gastrointestinal disorders: a two-sample Mendelian randomization study
BioMed Central » Genes & Nutrition
by Senbao Xu, Qiuyan Luo, Jian He, Xiling Chen, Simin Li and Yang Bai
6M ago
Previous observational studies have shown associations between vitamin Ds and FGIDS[Including irritable bowel syndrome(IBS) and functional dyspepsia(FD)]. However, the association is controversial and the caus ..read more
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Coffee consumption and periodontitis: a Mendelian Randomization study
BioMed Central » Genes & Nutrition
by Wan-Zhe Liao, Zhi-Yi Zhou, Zi-Kai Lin, Shuo-Jia Xie, Ya-Fang Zheng, Jun-Tao Wang, Jun-Huang Zheng, Hao-Kai Chen, Wu-Shu Chen and Xu-Guang Guo
6M ago
Coffee is one of the most consumed beverages in the world, coffee consumption has been growing in the United States over the past 20 years. Periodontitis is defined by the pathologic loss of the periodontal li ..read more
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Paternal high-fat diet altered SETD2 gene methylation in sperm of F0 and F1 mice
BioMed Central » Genes & Nutrition
by Suhua Wei, Shiwei Luo, Haifeng Zhang, Yandong Li and Juan Zhao
6M ago
Paternal high-fat diet (HFD) can alter the epigenetics of sperm DNA, resulting in the transmission of obesity-related traits to the offspring. Previous studies have mainly focused on the HFD-induced changes in ..read more
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Causal effects of serum lipid biomarkers on early age-related macular degeneration using Mendelian randomization
BioMed Central » Genes & Nutrition
by Fen-Fen Li, Yuqin Wang, Lishuang Chen, Chong Chen, Qi Chen, Lue Xiang, Feng-Qin Rao, Li-Jun Shen, Qin-Xiang Zheng, Quanyong Yi and Xiu-Feng Huang
7M ago
Age-related macular degeneration (AMD) is one of the major causes of vision loss. Early AMD needs to be taken seriously, but the causal effects of lipid biomarkers on early AMD remain unclear ..read more
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Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia
BioMed Central » Genes & Nutrition
by Alessandro Rossi, Antonia Assunto, Carmen Rosano, Sara Tucci, Margherita Ruoppolo, Marianna Caterino, Francesca Pirozzi, Pietro Strisciuglio, Giancarlo Parenti and Daniela Melis
9M ago
Glycogen storage disease type Ia (GSDIa) is an inborn metabolic disorder caused by the deficiency of glucose-6-phospatase-α (G6Pase-α) leading to mitochondrial dysfunction. It remains unclear whether mitochond ..read more
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Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial
BioMed Central » Genes & Nutrition
by Sahar Cheshmeh, Negin Elahi, Maysa Ghayyem, Elaheh Mosaieby, Shima Moradi, Yahya Pasdar, Susan Tahmasebi and Mehdi Moradinazar
1y ago
Polycystic ovary syndrome (PCOS) is an endocrine disease in which related to obesity, metabolic disorders and is considered as one of the main causes of infertility in women. This trial was investigated the ef ..read more
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