Killing Senescent Cells to Delay Aging & the Liability of Referrals
Physician's Weekly
by Physician's Weekly
1w ago
Peter de Keizer (Associate Professor, University Medical Center Utrecht, Netherlands) and founder and managing director of Cleara Biotech B.V. discusses his drive to understand how cells that stop dividing and enter a “holding pattern,” known to cell biologists as senescence, drive disease and aging. We talk about how the peptides he has developed, called FOXO4 peptides, will enter clinical trials next year in patients with liver metastases. They work by selectively killing senescent cells, which in turn might unlock localized tissue regeneration programs. This is really cool stuff, and I bet ..read more
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97% With Knee Pain Struggle With ADLs, Physician Entrepreneurship Potential
Physician's Weekly
by Physician's Weekly
2w ago
Brian Carr, MD, discusses results of the Standing Up to Knee Pain: The Physical, Social, and Mental Impact of Knee OA survey, which polled 500 US adults who have been treated for chronic knee pain and/or osteoarthritis (OA) of the knee. It found that although 100% of patients have tried some form of treatment to address their pain, a staggering 97% still report that their daily lives are negatively impacted by their condition. The majority (75%) had trouble climbing stairs and exercising, and more than one-half reported that knee pain impaired their overall health and fitness. Also, Physician ..read more
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Anticipated Medical Innovations for 2023
Physician's Weekly
by Physician's Weekly
3w ago
As 2023 is upon us, we are probably being realistic to expect continued inflation, a choppy economy, COVID-19 disruptions in healthcare, and on-going supply chain disruptions continuing into the year. Some leaders in healthcare systems are even predicting an “exceptionally turbulent 2023.”1 While inflation appears to be stabilizing, the higher cost of consumer goods is making it difficult for some people to pay for medical services, therapies, and devices. As a result, healthcare consumers might put off buying prescriptions or medical devices that can help them treat or monitor a condition.&nb ..read more
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The Top Medical Innovations of 2022!
Physician's Weekly
by Physician's Weekly
1M ago
Co-hosts Dr. Alex McDonald and Dr. Rachel Giles give their perspectives, in no particular order of importance, on our choices for the top 14 medical innovations for 2022. Some are already in practice, while others are recent breakthroughs not quite ready for “prime time.” All-in-all it was a great year for medical science; let us know what you think the biggest medical innovations were in 2022!  We wish you a safe and healthy holiday season! We’ll be back the first week of January 2023 with an episode dedicated to looking at anticipated medical breakthroughs in 2023!   ..read more
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Employment Contract Must-Knows & Unmet Non-Communicable Disease Prevention Needs
Physician's Weekly
by Physician's Weekly
1M ago
In this episode we have two interviews about two different—but both very important—topics. In the second interview, Dr. Celestin Hategeka, from the Department of Global Health and Population, Harvard TH Chan School of Public Health, discusses his recently published systematic review in PLoS Medicine that identified several unmet needs in noncommunicable disease prevention, as well as control interventions, in low- and middle-income countries.  But first, our regular contributor, Dr. MedLaw—a board-certified radiologist and medical malpractice attorney—discusses the important topic of empl ..read more
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Leadership in Medicine & Daily Exercise Benefits Breast Cancer Survivors
Physician's Weekly
by Physician's Weekly
1M ago
In this episode, we have two interviews, about two completely different topics, although they are both about taking charge of the problem at hand. First, PW Editorial Board Member Dr. Alex McDonald speaks with Dr. Jay W. Lee, CMO at Share Our Selves, a federally qualified health center in Orange County, CA. Respected and known as a relational, facilitative leader who motivates and empowers his team to think big and deliver on the organizational mission, his key strengths include practice transformation, health equity, strategic planning, health policy and management, and digital health/social ..read more
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InDEPTH: Excess Nitrogen in the Body
Physician's Weekly
by Physician's Weekly
2M ago
With most Americans recently celebrating Thanksgiving by joining friends and family over a large, turkey-heavy celebratory meal, we take an inDEPTH look at how our bodies deal with excess nitrogen.  Animals mostly excrete excess nitrogen as ammonia, urea, or uric acid, which is produced during protein metabolism. Ammonia is the direct waste produced as a byproduct of protein metabolism by all animals. But because of its toxicity, many animals convert ammonia into a less toxic form. The major excretory product in humans is urea, which is excreted in urine by the kidneys.  Fun fact: b ..read more
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InDEPTH: The LDL-C Revolution
Physician's Weekly
by Physician's Weekly
2M ago
We are entering holiday season, and as a recent study published in the journal Atherosclerosis recently showed, celebrating the winter holidays is associated with up to 20% higher levels of total and LDL cholesterol, as well as up to a 15% higher risk for hypercholesterolemia in the general population. Although the holiday season is not a great time for a diagnosis of hypercholesterolemia, it is a great time to start talking about some of the revolutionary new methods to treat hyperlipidemia. To take up that challenge, we take an in-depth look at two new studies just reported at the American ..read more
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An inDEPTH Look at Movember: Updates in Prostate Cancer
Physician's Weekly
by Physician's Weekly
2M ago
Urological surgeon Phillip Cornford, BSc(hons), MB, BS, FRCS(Urol), MD, FEBU, (University of Liverpool) discusses unmet needs in early prostate cancer detection and exciting new techniques for advanced disease. Also, biotech industry expert Annaleen Daemen speaks about various innovative approaches to treatment-resistant prostate cancer, including the prospect of genome-driven diagnostics leading clinical care decisions. Enjoy ..read more
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InDEPTH: Prevention in Primary Care
Physician's Weekly
by Physician's Weekly
3M ago
This week, we take a deep dive into the benefits and problems facing primary care physicians, through the lenses of a family physician and an academic team. Kevin Grumbach, MD, explains to PW Editorial Board Member Alex McDonald, MD, why change is needed now in primary care or the “critical sector to the health of our people is about to implode.” Also, Steven Atlas, MD, discusses his JAMA study results, which turned up some important deficiencies in systems for managing abnormal cancer screening test results that can ultimately improve prevention in primary care.  ..read more
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