Human Breast Milk Exosomal miRNAs are Influenced by Premature Delivery and Affect Neurodevelopment
Molecular Nutrition & Food Research
by Ling Ma, Yanyan Huo, Qingyuan Tang, Xiulian Wang, Weiqin Wang, Dan Wu, Yicheng Li, Lingyan Chen, Shasha Wang, Yiwen Zhu, Wenli Wang, Yuan Liu, Nanjie Xu, Li Chen, Guangjun Yu, Jinjin Chen
13h ago
This study finds that specifically high expression of miR-3168 in premature breast milk exosomes affects the proliferation of neural stem cells and is required for neural stem cells to differentiate into neurons. Scope This study investigates the exosomal microRNA (miRNA) profiles of term and preterm breast milk, including the most abundant and differentially expressed (DE) miRNAs, and their impact on neurodevelopment in infants. Methods and Results Mature milk is collected from the mothers of term and preterm infants. Using high-throughput sequencing and subsequent data analysis, exosomal m ..read more
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The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation
Molecular Nutrition & Food Research
by Mengcheng Jin, Tangbin Zou, Hairong Huang, Ming Chen, Haoqi Zou, Baoyan Chen, Chengze Lai, Huawen Li, Peiwen Zhang
13h ago
Coenzyme Q10 (CoQ10) regulates high-fat diet-induced bile acid (BA) metabolism in mice, mediated by activation of the FXR pathway and increased levels of BA in the intestine and blood. Intestinal BA activates the TGR5 pathway in intestinal L-cells and promotes GLP-1 release. In addition, blood BA activates TGR5 in brown adipose tissue and triggers increased UCP1. Scope Bile acids play a crucial role in lipid absorption and the regulation of lipid, glucose, and energy homeostasis. Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and relat ..read more
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Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank
Molecular Nutrition & Food Research
by Yue Li, Yuwei Lai, Tingting Geng, Peng‐Fei Xia, Jun‐Xiang Chen, Zhou‐Zheng Tu, Kun Yang, Yun‐Fei Liao, Gang Liu, An Pan
3d ago
In this prospective cohort study of individuals with type 2 diabetes (T2D), higher ultraprocessed food (UPF) intakes are associated with increased risks of overall cardiovascular disease (CVD), coronary heart disease, and heart failure. The higher risk of overall CVD associated with higher UPF consumption possibly goes through pathways that include renal function, lipid metabolism, inflammation, and body weight. Our study supports the need to stress the importance of decreasing UPF intake in dietary guidelines for T2D patients. Scope Among patients with diabetes, who have modified nutritiona ..read more
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Fructooligosaccharides Intake during Pregnancy Improves Metabolic Phenotype of Offspring in High Fat Diet‐Induced Obese Mice
Molecular Nutrition & Food Research
by Junki Miyamoto, Yuna Ando, Akari Nishida, Mayu Yamano, Shunsuke Suzuki, Hiromi Takada, Ikuo Kimura
3d ago
The material gut microbial short-chain fatty acid derived from fructooligosaccharides facilitates the regulation of energy metabolism in offspring. Scope Obesity and metabolic diseases are closely associated, and individuals who become obese are also prone to type 2 diabetes and cardiovascular disorders. Gut microbiota is mediated by diet and can influence host metabolism and the incidence of metabolic disorders. Recent studies have suggested that improving gut microbiota through a fructooligosaccharide (FOS)-supplemented diet may ameliorate obesity and other metabolic disorders. Although ac ..read more
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High Fat Diet–Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies
Molecular Nutrition & Food Research
by Yuri Haneishi, Lucia Treppiccione, Francesco Maurano, Diomira Luongo, Junki Miyamoto, Mauro Rossi
3d ago
Wheat gluten may play a role for development of life-style related diseases in populations on a high fat diet. Mice feed high fat diet show that wheat gliadin consumption affects glucose and lipid metabolic homeostasis, alters the gut microbiota and the immune cell profile in liver. Abstract The intestinal immune system plays a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function, and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammati ..read more
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Molecular Characterization of the Allergenic Arginine Kinase from the Edible Insect Hermetia illucens (Black Soldier Fly)
Molecular Nutrition & Food Research
by Danila Delfino, Barbara Prandi, Luisa Calcinai, Erminia Ridolo, Luca Dellafiora, Lorenzo Pedroni, Francesca Nicoletta, Davide Cavazzini, Tullia Tedeschi, Claudia Folli
3d ago
In this study, the molecular characterization and allergenicity analysis of Arginine Kinase (AK) from the edible insect Hermetia illucens are reported. AK carries putative linear and conformational epitopes, exhibits the ability to cross-react with mite and shrimp allergens, and therefore may pose a risk to allergic consumers. However, its structure is altered at high temperature and after digestion, possibly leading to reduced allergenicity. Scope Arginine kinase (AK) is an important enzyme for energy metabolism of invertebrate cells by participating in the maintenance of constant levels of ..read more
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Issue Information: Mol. Nutr. Food Res. 7'24
Molecular Nutrition & Food Research
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6d ago
Molecular Nutrition &Food Research, Volume 68, Issue 7, April 2024 ..read more
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Curry‐Odorants and Their Metabolites Transfer into Human Milk and Urine
Molecular Nutrition & Food Research
by Marcel W. Debong, Ines Homm, Michael Gigl, Roman Lang, Thomas Hofmann, Andrea Buettner, Corinna Dawid, Helene M. Loos
1w ago
Aroma compounds from a standardized curry dish and their metabolic fate are being studied within the human lactating body. Donated milk and urine samples are analyzed by stir bar sorptive extraction thermal desorption gas chromatography mass spectrometry. Instrumental analyses show significant transitions of linalool into milk, of linalool, cuminaldehyde, cinnamaldehyde, and eugenol into the urine. Furthermore, the results show a transition of aroma-glucuronides into human milk and thereby complement previous insights in the excretion and time patterns of flavor compounds in breastfeeding wom ..read more
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Polyphenol Extracts from Ziziphus jujuba Mill. “Junzao” Attenuates Ulcerative Colitis by Inhibiting the NLRP3 and MAPKs Signaling Pathways and Regulating Gut Microbiota Homeostasis in Mice
Molecular Nutrition & Food Research
by Xiaobo Wei, Ni Ma, Wen Yang, Jinhu Tian, Huiyan Liu, Haitian Fang
1w ago
Polyphenol extracts from red jujube probably inhibit the development of ulcerative colitis by suppressing the NLRP3 and MAPKs signaling pathways and regulating gut microbiota homeostasis. Scope Polyphenols are the major active substances in red jujube fruit, and their anti-inflammatory and antioxidant activities suggest their potential utility in the prevention of ulcerative colitis (UC). Methods and results In this study, the effect of polyphenol extracts from red jujube (Ziziphus jujuba Mill. “Junzao”) (PERJ) on the dextron sulfate sodium (DSS)-induced UC mice is investigated. The result s ..read more
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Investigation of Antiproliferative Effects of Combinations of White and Black Garlic Extracts with 5‐Fluorouracil (5‐FU) on Caco‐2 Colorectal Adenocarcinoma Cells
Molecular Nutrition & Food Research
by Derya Ozalp Unal, Tevhide Sel
1w ago
This study examined the antioxidant and antiproliferative effects of cold-extracted white and black garlic extracts. White garlic extracted in methanol exhibited the highest caspase-3 activity. Black garlic extracted in water showed the highest antioxidant activity and phenolic content. Additionally, combining garlic with chemopreventive drugs like 5-FU is effective against colon cancer cells. Abstract Garlic is rich in bioactive compounds that are effective against colon cancer cells. This study tests the antioxidant and antiproliferative effects of cold-extracted white and black garlic ext ..read more
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