Lactoferrin (LF) is a member of the transferrin family. LF has many biological functions such as antibacterial, antiviral, immunomodulatory, and anticancer. The purpose of this study is to explore the research trend of LF through bibliometric analysis. Based on CiteSpace and VOSviewer, the number of papers published, countries, institutions, authors, journals, keywords, and so on are analyzed. Scope Lactoferrin (LF) is an iron-bound protein with a molecular weight of about 80 kDa. LF has many biological functions such as antibacterial, antiviral, immunomodulatory, and anticancer. The pu ..read more

LGG and TA individual treatments significantly improve diarrhea, maybe through a selective immunomodulatory cytokine-dependent mechanism. LGG supplement decreases intestinal tissue concentrations of TNF-α and NF-kB. On the other hand, TA decreases INF-γ and TGF-β. When both treatments are combined, a synergistic effect is achieved. Scope Diarrhea is a common health issue that contributes to a significant annual death rate among children and the elderly worldwide. The anti-diarrheal activity of Lactobacillus rhamnosus GG (LGG) and tannic acid (TA), alone or combined, is examined, in addition ..read more

The acquisition of novel insights derived from the biological and genetic profiles of patients will pave the way for tailored interventions and guidance, facilitated by pioneering methodologies and investigations in research. Such advancements will lead to shifts in dietary patterns and proactively mitigate the onset of neurological disorders ..read more

Molecular Nutrition &Food Research, Volume 68, Issue 13, July 2024 ..read more

This study identifies proteins in edible insect-based food products derived from cricket (Acheta domesticus) and black soldier fly larvae (Hermetia illucens) that can cause allergic reactions in consumers with shellfish allergy by analyzing the protein similarities, IgE-antibody binding capacity and epitopes; and highlights that the current crustacean allergen test kits are not suitable for detecting cricket contamination in foods. Scope Edible insect proteins are increasingly introduced as an alternative sustainable food source to address the world's need to feed the growing population. Tro ..read more

This study shows that α-ionone activates the olfactory receptor OR10A6 in squamous cell carcinoma A431 cells, inducing the Hippo pathway and suppressing tumor growth. In both A431 cells and xenograft mouse models, α-ionone prevents proliferation and migration, and induces apoptosis, effects that are lost with OR10A6 knockdown, highlighting α-ionone's potential as a squamous cell carcinoma therapeutic. Scope This study aims to investigate the anticancer properties of α-ionone in squamous cell carcinoma (SCC). Methods and results The expression of OR10A6 together with olfactory receptor signal ..read more

FOS show renoprotective effects by reducing renal inflammation, oxidative stress, fibrosis, and apoptosis, attenuating the impaired renal signaling associated with organic anion transporter 3 (Oat3) function. The effects of FOS are potentially due to the bifidogenic effects in improving gut dysbiosis and the attenuation of gut leakage which could inhibit various inflammation responses in the renal cells. Scope High-fat diet (HFD) consumption causes obesity and gut dysbiosis which induces kidney injury. It has been reported that prebiotics improve gut dysbiosis and insulin sensitivity and dec ..read more

Chronic polar lipid supplementation during neuronal maturation enhances glutamate receptor expression and basal excitatory neurotransmission. Scope Polar lipids, such as gangliosides and phospholipids, are fundamental structural components that play critical roles in the development and maturation of neurons in the brain. Recent evidence has demonstrated that dietary intakes of polar lipids in early life are associated with improved cognitive outcomes during infancy and adolescence. However, the specific mechanisms through which these lipids impact cognition remain unclear. Methods and resul ..read more

A possible mechanism by which isorhamnetin promotes porcine oocyte maturation. Isorhamnetin enhances polar body extrusion rate and mitochondrial function, but inhibits reactive oxidative stress, apoptosis, and ER stress to promote oocyte maturation. ΔΨ m, mitochondrial membrane potential. Scope Isorhamnetin is a natural flavonoid with various pharmacological activities, which can be widely and continuously ingested by humans and animals through their daily diet. The aim of this study is to explore the benefits and molecular mechanisms of isorhamnetin on oocyte maturation. Methods and results ..read more

This narrative review evaluates the role of diet in the relationship between depression and AD. Evidence suggests diet can influence the risk of both conditions directly and indirectly. Key dietary components like polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to the Mediterranean diet, may offer protection against depression and AD. Purpose of Review This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings AD and depression are often comorbid, and depression appear ..read more