Epilepsy Currents, Ahead of Print. Predicting Seizure Outcome After Epilepsy Surgery: Do We Need More Complex Models, Larger Samples, or Better Data? Eriksson MH, Ripart M, Piper RJ, Piper RJ, Moeller F, Das KB, Eltze C, Cooray G, Booth J, Whitaker KJ, Chari A, Sanfilippo PM, Caballero AP, Menzies L, McTague A, Tisdall MM, Cross JH, Baldeweg T, Adler S, Wagstyl K. Epilepsia. 2023;64(8):2014-2026. doi:10.1111/epi.17637 Objective:The accurate prediction of seizure freedom after epilepsy surgery remains challenging. We investigated if (1) training more complex models, (2) recruiting larger sample ..read more

Epilepsy Currents, Ahead of Print. Seizures Cause Prolonged Impairment of Ventilation, CO2 Chemoreception and Thermoregulation Teran FA, Sainju RK, Bravo E, Wagnon J, Kim Y, Granner A, Gehlbach BK, Richerson GB. J Neurosci. 2023;43(27):4959-4971. doi:10.1523/JNEUROSCI.0450-23.2023. PMID: 37160367 Sudden unexpected death in epilepsy (SUDEP) has been linked to respiratory dysfunction, but the mechanisms underlying this association remain unclear. Here we found that both focal and generalized convulsive seizures (GCSs) in epilepsy patients caused a prolonged decrease in the hypercapnic ventilator ..read more

Epilepsy Currents, Volume 23, Issue 5, Page 298-302, September–October 2023. This review discusses the use of neurostimulation therapies for epilepsy treatment, including vagal nerve stimulation, responsive neurostimulation, and deep brain stimulation. Different therapeutic strategies and their underlying mechanisms are explored, with a focus on optimizing parameters for seizure reduction. The review also highlights the paradigm shift toward a more diverse and multimodal approach to deep brain neuromodulation ..read more

Epilepsy Currents, Ahead of Print. Gene Therapy Ameliorates Spontaneous Seizures Associated With Cortical Neuron Loss in a Cln2R207X Mouse Model Takahashi K, Eultgen EM, Wang S, Rensing NR, Nelvagal HR, Dearborn JT, Danos O, Buss N, Sands MS, Wong M, Cooper JD. 2023. J Clin Invest. 133(12):e165908. doi:10.1172/JCI165908 Although a disease-modifying therapy for classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) exists, poor understanding of cellular pathophysiology has hampered the development of more effective and persistent therapies. Here, we investigated the nature and pro ..read more

Epilepsy Currents, Ahead of Print. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay EZ, Robert SM, Kiziltug E, Damisah EC, Nelson-Williams C, Zhu G, Kong W, Huang AY, Stronge E, Phillips HW, Chhouk BH, Bizzotto S, Chen MH, Adikari TN, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer IE, Berkovic SF, Haider S, Hildebrand MS, Yang E, Gunel M, Lifton RP, Richardson RM, Blümcke I, Alexandrescu S, Huttner A, Heinzen EL, Zhu J, Poduri A, DeLanerolle N, Spencer DD ..read more

Epilepsy Currents, Ahead of Print. RGS14 Limits Seizure-Induced Mitochondrial Oxidative Stress and Pathology in Hippocampus Harbin NH, Lustberg DJ, Hurst C, Pare J, Crotty KM, Waters AL, Yeligar SM, Smith Y, Seyfried NT, Weinschenker D, Hepler JR. Neurobiol Dis. 2023;181:106128. doi:10.1016/j.nbd.2023.106128. PMID: 37075948 RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. In these neurons, RGS14 suppresses glutamate-induced calcium influx and related G protein and ERK signaling in dendritic spines to restrain p ..read more

Epilepsy Currents, Ahead of Print. Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model Sinka L, Abraira L, Imbach LL, Zieglgänsberger D, Santamarina E, Álvarez-Sabín J, Ferreira-Atuesta C, Katan M, Scherrer N, Bicciato G, Terziev R, Simmen C, Schubert KM, Elshahabi A, Baumann CR, Döhler N, Erdélyi-Canavese B, Felbecker A, Siebel P, Winklehner M, von Oertzen TJ, Wagner JN, Gigli GL, Serafini A, Nilo A, Janes F, Merlino G, Valente M, Zafra-Sierra MP, Bayona-Ortiz H, Conrad J, Evers S, Lochner P, Roell F, Brigo ..read more

Epilepsy Currents, Ahead of Print. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry Peltola J, Colon AJ, Pimentel J, Coenen VA, Gil-Nagel A, Gonçalves Ferreira A, Lehtimäki K, Ryvlin P, Taylor RS, Ackermans L, Ardesch J, Bentes C, Bosak M, Burneo JG, Chamadoira C, Elger CE, Erőss L, Fabo D, Faulkner H, Gawlowicz J, Gharabaghi A, Iacoangeli M, Janszky J, Järvenpää S, Kaufmann E, Kho KH, Kumlien E, Laufs H, Lettieri C, Linhares P, Noachtar S, Parrent A, Pataraia E, Patel NK, Peralta AR, Rácz A, Campos AR, Rego R, R ..read more

Epilepsy Currents, Ahead of Print. MRI-Based Deep Learning Can Discriminate Between Temporal Lobe Epilepsy, Alzheimer’s Disease, and Healthy Controls Chang AJ, Roth R, Bougioukli E, Ruber T, Keller SS, Drane DL, Gross RE, Welsh J, Abrol A, Calhoun V, Karakis I, Kaestner E, Weber B, McDonald C, Gleichgerrcht E, Bonilha L; Alzheimer’s Disease Neuroimaging Initiative. Commun Med (Lond). 2023;3(1):33. doi:10.1038/s43856-023-00262-4.Background:Radiological identification of temporal lobe epilepsy (TLE) is crucial for diagnosis and treatment planning. TLE neuroimaging abnormalities are pervasive at ..read more

Epilepsy Currents, Ahead of Print. Detecting Temporal Lobe Seizures in Ultra Long-Term Subcutaneous EEG Using Algorithm-Based Data Reduction Remvig LS, Duun-Henriksen J, Fürbass F, Hartmann M, Viana PF, Kappel Overby AM, Weisdorf S, Richardson MP, Beniczky S, Kjaer TW. Clin Neurophysiol. 2022;142:86-93. doi:10.1016/j.clinph.2022.07.504. PMID: 35987094 Objective:Ultra long-term monitoring with subcutaneous EEG (sqEEG) offers objective outpatient recording of electrographic seizures as an alternative to self-reported epileptic seizure diaries. This methodology requires an algorithm-based automat ..read more