I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the unassailable importance of diet in addressing inflammation, metabolic health, chronic disease, and longevity, and the role that fatty acids play in that milieu. And while he and I might not agree that p ..read more

Dr. Sandison confesses that when she first heard Dr. Dale Bredesen talk about his work reversing cognitive decline and Alzheimer's disease she was skeptical. But when she started to apply the Bredesen principles in her clinical work and saw just how meaningful the improvements were to patients' symptoms and quality of life, as she puts it: "...how do I do anything else with my life, but basically tell as many people who will listen that this is possible?" She then went on to found the first two residential care facilities for individuals with cognitive decline that are based on the Bredesen ap ..read more

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging a ..read more

In this episode, I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the unassailable importance of diet in addressing inflammation, metabolic health, chronic disease, and longevity, and the role that fatty acids play in that milieu. And while he and I might ..read more

Gear up for an enlightening dive with Dr. Tara Harding, a vanguard in the realm of women’s health and fertility. Renowned for her exceptional work as a family nurse practitioner and fertility coach, Dr. Harding brings a wealth of knowledge from her battle against infertility and medical gaslighting, all while breaking barriers and fostering a supportive community for those navigating the complex journey of infertility. This conversation not only highlights innovative diagnostic tools like Mira but also delves into the nuances of managing conditions like PCOS and endometriosis. Dr. Harding’s pe ..read more

Fellow clinicians, get ready for a mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. And being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions). It’s heady stuff, but amazingly, it is where we are headed today. Dr. Price illustrates the incred ..read more

It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano- a reproductive biologist by training- realized that because we are able to create life, that same body of information could be harnessed to create youth-that is, radically reverse our biological aging process to a younger time point without losing cellular identity.  He and his lab embarked on unpacking his epiphany back in 2014. They made the radical choice to conduct their investigations in human cells and tissue rather than in rodents, with the expectation that such a start could better bridge to ..read more

Aging itself stands as the paramount driver of disease. As functional practitioners, the question arises: How can we assess biological age to make precise corrections that foster both healthspan and lifespan? Enter the era of omics, where metabolomics emerges as an exceptional tool with transformative potential. I'm thrilled to welcome back Dr. Betsy Redmond, longtime friend and the senior education specialist at Diagnostic Solutions Laboratory, to New Frontiers to lead us on this discussion.Together, we'll take a deep dive into specific metabolites and pathways intricately linked to aging, mo ..read more

Working in healthcare brings a unique set of challenges and stressors. But the truth is that any of us can get to burnout through challenging circumstances of work or study. And the consequences can range from severe to devastating. Burnout still hasn't been fully understood or recognized by the medical profession and other industries - there is still no official diagnosis classification. Along with other mental health disorders, it is often still (wrongly) stigmatized and can even sometimes be seen as a "badge of honor," much to our detriment. Dr. Jonathan Prousky, Chief Naturopathic Medical ..read more

When it comes to mitochondrial health, few nutrients have burst onto the bioenergetics stage with quite the impressive force as the postbiotic rock star Urolithin A (UA). On this New Frontiers episode Dr. Chris Rinsch, co-founder of Amazentis / Timeline, shares the incredible scientific journey of UA's discovery and subsequent unfolding of its many benefits, as confirmed by multiple clinical studies. Together, we explore UA's mechanisms of action, including the role of the microbiome, and exciting preliminary research on UA's potential to reverse immune aging. Of course, our conversation would ..read more