Epstein–Barr virus, Cytomegalovirus, and Herpes Simplex-1/2 reactivations in critically ill patients with COVID-19
Intensive Care Medicine Experimental
by Alessia Mattei, Lorenzo Schiavoni, Elisabetta Riva, Massimo Ciccozzi, Roberta Veralli, Angela Urselli, Vincenzo Citriniti, Antonio Nenna, Giuseppe Pascarella, Fabio Costa, Rita Cataldo, Felice Eugenio Agrò and Massimiliano Carassiti
2d ago
To assess the incidences of Herpes Simplex-1 and 2 (HSV-1, HSV-2), Cytomegalovirus (CMV), Epstein–Barr Virus (EBV) reactivations in critically ill COVID-19 patients. To determine the association between viral ..read more
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Ineffectiveness of hemoadsorption in large animals with abdominal sepsis: a randomized controlled porcine study
Intensive Care Medicine Experimental
by Vaclav Tegl, Jan Horak, Lukas Nalos, Michala Horakova, Milan Stengl, Martin Matejovic and Jan Benes
4d ago
The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on rob ..read more
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Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers
Intensive Care Medicine Experimental
by Bashar N. Hilderink, Reinier F. Crane, Bas van den Bogaard, Janesh Pillay and Nicole P. Juffermans
1w ago
Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in cl ..read more
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Impact of respiratory cycle during mechanical ventilation on beat-to-beat right ventricle stroke volume estimation by pulmonary artery pulse wave analysis
Intensive Care Medicine Experimental
by Arnoldo Santos, M. Ignacio Monge-García, João Batista Borges, Jaime Retamal, Gerardo Tusman, Anders Larsson and Fernando Suarez-Sipmann
2w ago
The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenc ..read more
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The ongoing journey in targeting hemodynamic interventions: missing miles for missing the last micron?
Intensive Care Medicine Experimental
by Johannes Heymer and Daniel Raepple
2w ago
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Isoflurane, like sepsis, decreases CYP1A2 liver enzyme activity in intensive care patients: a clinical study and network model
Intensive Care Medicine Experimental
by Thomas Köhler, Elke Schwier, Janina Praxenthaler, Carmen Kirchner, Günther Winde, Björn Koos and Dietrich Henzler
2w ago
Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum li ..read more
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Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data
Intensive Care Medicine Experimental
by Simone Gattarello, Fabio Lombardo, Federica Romitti, Rosanna D’Albo, Mara Velati, Isabella Fratti, Tommaso Pozzi, Rosmery Nicolardi, Antonio Fioccola, Mattia Busana, Francesca Collino, Peter Herrmann, Luigi Camporota, Michael Quintel, Onnen Moerer, Leif Saager…
1M ago
The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney f ..read more
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Flow-controlled ventilation decreases mechanical power in postoperative ICU patients
Intensive Care Medicine Experimental
by Julien P. Van Oosten, Juliette E. Francovich, Peter Somhorst, Philip van der Zee, Henrik Endeman, Diederik A. M. P. J. Gommers and Annemijn H. Jonkman
1M ago
Mechanical power (MP) is the energy delivered by the ventilator to the respiratory system and combines factors related to the development of ventilator-induced lung injury (VILI). Flow-controlled ventilation ..read more
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Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Intensive Care Medicine Experimental
by Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud and Patricia C. Liaw
1M ago
Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predi ..read more
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Six methods to determine expiratory time constants in mechanically ventilated patients: a prospective observational physiology study
Intensive Care Medicine Experimental
by Filip Depta, Caitlyn M. Chiofolo, Nicolas W. Chbat, Neil R. Euliano, Michael A. Gentile, Dušan Rybár, Viliam Donič and Marko Zdravkovic
1M ago
Expiratory time constant (τ) objectively assesses the speed of exhalation and can guide adjustments of the respiratory rate and the I:E ratio with the goal of achieving complete exhalation. Multiple methods of ob ..read more
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