This article describes growth retardation and change in facial appearance with development of moon face as the first symptoms of CS. Growth retardation is prior to development of moon face. CRH test and BIPSS contribute to confirming the diagnosis of CD and excluding ectopic ACTH syndrome in children with invisible adenoma on MRI ..read more

This case report details the diagnostic work-up in a young woman with clinical presentation of heterotopic pancreas. Here, imaging and endoscopic findings of a newly diagnosed submucosal mass in the gastric antrum are well described. Technical issues of endosonographically-navigated drainage of symptomatic fluid collection in heterotopic pancreas with a plastic double pigtail stent under fluoroscopic control are also presented. Fluid collections after acute pancreatitis in heterotopic pancreas can be successfully managed by endoscopy ..read more

The goal of this study was to use time-lapse monitoring to find key morphokinetic parameters in pre-implantation human embryos, which are essential for the identification of embryos with high developmental potential, specifically embryos leading to the birth of a healthy child ..read more

The use of epidural analgesia in neonates raises concerns due to possible drug cumulation and toxicity. In general, studying PK and modelling using plasma concentrations of the used local anaesthetic (LA) in neonates is applicable in daily clinical practice because the intravenous blood volume is small, and the number of samples does not have to be large. To the best of their knowledge, this is the first case report of the pharmacokinetic profile of levobupivacaine (LA) achieving pharmacotherapy goals during epidural use in preterm neonates. A special adjustment of the laboratory method reduce ..read more

The "qNOX" index for the Conox monitor was predicted to be responsive to the probability of reaction to nociceptive stimulation during general anaesthesia. The results show that the qNOX index does not reflect development of detectable signs related to nociceptive stimulation during adult cardiac surgery and could be affected by simultaneous use of muscle relaxants ..read more

This research study was focused on changes in DNA methylation in specific tumor supressor genes in endometrial hyperplasia. The authors performed a retrospective study of endometrial tissue of 164 patients treated in their department from 2007 to 2014 dividing them into three subsets: atypical hyperplasia, hyperplasia without atypia and a control group with normal endometrial tissue. 25 selected genes using the methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) probe set were tested. Differences in DNA methylation among the groups were found in PTEN, CDH13, and MSH ..read more

Six multiple sclerosis (MS) patients with a rapid progression of disability underwent immunoablative therapy followed by autologous hematopoietic stem cell transplantation (AHSCT) as the first-line disease-modifying therapy, between 2018 and 2021. Four out of six patients showed disability progression after AHSCT, so the rapid progression of MS was just slowed down by AHSCT. One patient developed activity on magnetic resonance imaging and two patients experienced mild relapses after AHSCT. None of the patients developed grade 4 non-hematological toxicity ..read more

The authors confirmed that the most common abnormalities leading to retinal vein occlusion (RVO) in patients under 50 years were systemic cardiovascular diseases, particularly arterial hypertension and hyperlipidaemia, and we found out that the risk factors for central RVO (CRVO), hemi-central RVO (HRVO) and branch RVO (BRVO) were similar. To the best of our knowledge, this is the only study to date which has examined the difference between RF presence in CRVO and HRVO patients compared to BRVO patients under the age of 50 ..read more

XGJZ-containing serum was obtained from obese rats treated with the XGJZ formula. The authors confirmed that XGJZ-containing serum can inhibit the differentiation of 3T3-L1 adipocytes, reduce the expression of lipogenic transcription factors, lipid accumulation, and lipid metabolism-related enzyme activity in differentiated 3T3-L1 adipocytes, thereby improving the risk of obesity and obesity-related diseases. It provides evidence for the mechanism of obesity ..read more

DNA damage is increased in hypertensive pts compared with healthy controls and this is confirmed with meta-analysis (comet: 26.6±11.0 vs 11.7±4.07; P<0.05; 8OHdG: 13.1±4.12 vs 6.97±2,67; P<0.05, gammaH2AX: no data available). Greater DNA damage is identified in more adverse cases. DNA damage correlates strongly with serum glycosylated haemoglobin (r=0.670; P<0.05) and total antioxidant status (r=-0.670 to -0.933; P<0.05). This is the first systematic review with meta-analysis showing that oxidative DNA damage is increased in humans with arterial hypertension ..read more