Nature Biomedical Engineering, Published online: 08 April 2024; doi:10.1038/s41551-024-01197-4 The densities of blood vessels and of tumour-associated macrophages are key predictive features of the degree of accumulation of polymeric and liposomal nanomedicines, as shown for specimens of mouse and human tumours ..read more

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01203-9 Publisher Correction: Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi ..read more

Nature Biomedical Engineering, Published online: 02 April 2024; doi:10.1038/s41551-024-01200-y Author Correction: Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation ..read more

Nature Biomedical Engineering, Published online: 01 April 2024; doi:10.1038/s41551-024-01195-6 Antigen-specific immunosuppression can be enhanced by genetically modifying mesenchymal stromal cells with chimaeric antigen receptors, as shown for the treatment of graft-versus-host disease in mice ..read more

Nature Biomedical Engineering, Published online: 01 April 2024; doi:10.1038/s41551-024-01190-x The esterification of butyrate to serine makes for an odourless and tasteless oral prodrug that ameliorated disease severity and reduced inflammatory responses in mouse models of rheumatoid arthritis and multiple sclerosis ..read more

Nature Biomedical Engineering, Published online: 27 March 2024; doi:10.1038/s41551-024-01192-9 By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multiple immune signalling pathways. Immunotherapy with mineralized bacteria suppressed various types of cancer in multiple animal models, eliciting both immune memory and abscopal antitumour effects ..read more

Nature Biomedical Engineering, Published online: 21 March 2024; doi:10.1038/s41551-024-01188-5 Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tumour cells ..read more

Nature Biomedical Engineering, Published online: 20 March 2024; doi:10.1038/s41551-024-01184-9 CRISPR–Cas12a was used to directly replace mouse antibody variable chain genes with human versions in primary B cells. The edited cells underwent affinity maturation in vivo, improving the potency of HIV-1 and SARS-CoV-2 neutralizing antibodies without loss of bioavailability. Affinity maturation of edited cells also enables new vaccine models and adaptive B cell therapies ..read more

Nature Biomedical Engineering, Published online: 18 March 2024; doi:10.1038/s41551-024-01183-w Wireless miniaturized implantable temperature sensors enable real-time monitoring of the progression of inflammatory bowel diseases, as shown in a mouse model of Crohn’s-disease-like ileitis ..read more

Nature Biomedical Engineering, Published online: 18 March 2024; doi:10.1038/s41551-024-01187-6 A patient-centred system that leverages the analysis of sweat via wearable sensors may better support the management of patients with substance-use disorders ..read more