Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer
Cellular & Molecular Biology Letters
by Xiao-Qian Li, Xiao-Ju Cheng, Jie Wu, Kai-Feng Wu and Tie Liu
1d ago
Non-small cell lung cancer (NSCLC), characterized by low survival rates and a high recurrence rate, is a major cause of cancer-related mortality. Aberrant activation of the PI3K/AKT/mTOR signaling pathway is a ..read more
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The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights
Cellular & Molecular Biology Letters
by Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen, Xingyu Wang, Tianci Liao, Mengying Zhao, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Yan Wang, Li Zhu and Linyuan Shen
1d ago
Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon ..read more
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MiR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A
Cellular & Molecular Biology Letters
by Ya Wang, Zhengyang Zhang, Hui Li, Min Wang, Yuting Qiu and Lili Lu
3d ago
Viral myocarditis (VMC) is a disease resulting from viral infection, which manifests as inflammation of myocardial cells. Until now, the treatment of VMC is still a great challenge for clinicians. Increasing s ..read more
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Reciprocal negative feedback between Prrx1 and miR-140-3p regulates rapid chondrogenesis in the regenerating antler
Cellular & Molecular Biology Letters
by Pengfei Hu, Guokun Zhang, Hengxing Ba, Jing Ren, Jiping Li, Zhen Wang and Chunyi Li
3d ago
During growth phase, antlers exhibit a very rapid rate of chondrogenesis. The antler is formed from its growth center reserve mesenchyme (RM) cells, which have been found to be the derivatives of paired relate ..read more
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Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b
Cellular & Molecular Biology Letters
by Jérôme Gilleron, Abderrahman Chafik, Sandra Lacas-Gervais, Jean-François Tanti and Mireille Cormont
3d ago
The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fuse ..read more
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Role of reactive oxygen species in myelodysplastic syndromes
Cellular & Molecular Biology Letters
by Qiangan Jing, Chaoting Zhou, Junyu Zhang, Ping Zhang, Yunyi Wu, Junyu Zhou, Xiangmin Tong, Yanchun Li, Jing Du and Ying Wang
1w ago
Reactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS product ..read more
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CRISPR–Cas9 applications in T cells and adoptive T cell therapies
Cellular & Molecular Biology Letters
by Xiaoying Chen, Shuhan Zhong, Yonghao Zhan and Xuepei Zhang
1w ago
T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different ..read more
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Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA–miRNA/protein axis
Cellular & Molecular Biology Letters
by Yuan Ci, Yuan Zhang and Xiaobo Zhang
2w ago
Long noncoding RNAs (lncRNAs) play essential roles in the tumorigenesis of gastric cancer. However, the influence of lncRNA methylation on gastric cancer stem cells (GCSCs) remains unclear ..read more
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Correction: A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
Cellular & Molecular Biology Letters
by Yan Liu, Zhujun Chao, Wei Ding, Tanfeng Fang, Xinxian Gu, Man Xue, Wei Wang, Rong Han and Wanping Sun
2w ago
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Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
Cellular & Molecular Biology Letters
by Meixuan Lin, Xiaoqiang Xu, Xiaoman Zhou, Hui Feng, Ruili Wang, Yunyun Yang, Jing Li, Ning Fan, Yazhuo Jiang, Xiang Li, Feng Guan and Zengqi Tan
3w ago
Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian cancer. Glycoconjugates are highly expressed on sEV and play important roles in sEV biog ..read more
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