MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region
Cell Communication and Signaling
by Yingchi Zhang, Tao Xu, Jie Xie, Hua Wu, Weihua Hu and Xuefeng Yuan
14h ago
The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mito ..read more
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Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications
Cell Communication and Signaling
by Xinyu Qiao, Junhao Yin, Zhihuan Zheng, Liangge Li and Xiujing Feng
14h ago
Sepsis, a prevalent critical condition in clinics, continues to be the leading cause of death from infections and a global healthcare issue. Among the organs susceptible to the harmful effects of sepsis, the l ..read more
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Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future
Cell Communication and Signaling
by Aref Yarahmadi, Mitra Zare, Masoomeh Aghayari, Hamed Afkhami and Gholam Ali Jafari
14h ago
Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges global ..read more
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Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NFκB
Cell Communication and Signaling
by Nilanjan Ganguly, Tapasi Das, Avishek Bhuniya, Ipsita Guha, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Saurav Bera, Jesmita Dhar, Shayani Dasgupta, Akata Saha, Tithi Ghosh, Juhina Das, Ugir Hossain Sk, Saptak Banerjee, Subrata Laskar…
3d ago
A water-soluble ingredient of mature leaves of the tropical mahogany ‘Neem’ (Azadirachta indica), was identified as glycoprotein, thus being named as ‘Neem Leaf Glycoprotein’ (NLGP). This non-toxic leaf-component ..read more
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A promising frontier: targeting NETs for stroke treatment breakthroughs
Cell Communication and Signaling
by Huijie Fang, Yunfei Bo, Zhongfei Hao, Ge Mang, Jiaqi Jin and Hongjun Wang
3d ago
Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and r ..read more
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Interleukin-4 protects retinal ganglion cells and promotes axon regeneration
Cell Communication and Signaling
by Zhaoyang Zuo, Bin Fan, Ziyuan Zhang, Yang Liang, Jing Chi and Guangyu Li
4d ago
The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of various vision-threatening disorders. Therefore, we investigate the e ..read more
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High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
Cell Communication and Signaling
by Lulu Ji, Xiaoli Zhang, Zhiguo Chen, Yuexiao Wang, Hengxuan Zhu, Yaru Nai, Yanyi Huang, Rujie Lai, Yu Zhong, Xiting Yang, Qiongtao Wang, Hanyang Hu and Lin Wang
5d ago
p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the mechanisms by which p66Shc affects autophagosome formation are not fully understood ..read more
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GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement
Cell Communication and Signaling
by Yuwei Duan, Bing Cai, Jing Guo, Chen Wang, Qingyun Mai, Yan Xu, Yang Zeng, Yue Shi, Boyan Wang, Chenhui Ding, Minghui Chen, Canquan Zhou and Yanwen Xu
5d ago
Antral follicles consist of an oocyte cumulus complex surrounding by somatic cells, including mural granulosa cells as the inner layer and theca cells as the outsider layer. The communications between oocytes ..read more
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Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
Cell Communication and Signaling
by Jana Ackmann, Alina Brüge, Lizaveta Gotina, Sungsu Lim, Kathrin Jahreis, Anna-Lena Vollbrecht, Yun Kyung Kim, Ae Nim Pae, Josephine Labus and Evgeni Ponimaskin
5d ago
Multiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the microtubule-associated protein Tau leads to the development of so-called tauopathies ch ..read more
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Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration
Cell Communication and Signaling
by Mei-Hua Jin, Lin Feng, Hong-Yi Xiang, Hu-Nan Sun, Ying-Hao Han and Taeho Kwon
1w ago
Neurodegenerative diseases are increasingly recognized for their association with oxidative stress, which leads to progressive dysfunction and loss of neurons, manifesting in cognitive and motor impairments. T ..read more
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